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Spots Global Cancer Trial Database for Integrin α6-targeted SPECT Imaging of Breast Cancer

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Trial Identification

Brief Title: Integrin α6-targeted SPECT Imaging of Breast Cancer

Official Title: First-in-human Pilot Study of an Integrin α6-targeted Radiotracer for SPECT Imaging of Breast Cancer

Study ID: NCT04289532

Conditions

Breast Cancer

Interventions

99mTc-RWY

Study Description

Brief Summary: A novel radiotracer 99mTc-RWY targeting Integrin α6 was developed, and the pilot first-in-human study for SPECT imaging of breast cancer was performed in seven healthy volunteers and two breast cancer patients to assess the safety and potential clinical applications of 99mTc-RWY.

Detailed Description: Integrin α6 associates with the survival and migration of breast cancer cells, which emerges as a predictor of reduced overall survival and worse prognosis. In this study, we developed an integrin α6-targeted radiotracer 99mTc-RWY for SPECT imaging of breast cancer. The safety, biodistribution and radiation dosimetry were studied in seven healthy volunteers, and the clinical potential of 99mTc-RWY was examined in two breast cancer patients. A single dose of 11.1 MBq/kg 99mTc-RWY was injected intravenously. Visual and semiquantitative methods were used to assess the SPECT/CT images. The routine Hematoxylin-Eosin (HE) staining and immunohistochemistry (IHC) staining were subsequently carried out to confirm the Integrin α6 expression of tumors.

Eligibility

Minimum Age: 25 Years

Eligible Ages: ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Peking University Health Science Center, Beijing, Beijing, China

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

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