The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.
Brief Title: Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer
Official Title: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women With Stage 0, I, or II Breast Cancer
Study ID: NCT00103181
Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in different ways may kill any tumor cells that remain after surgery. It is not yet known whether whole breast radiation therapy is more effective than partial breast radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial is studying whole breast radiation therapy to see how well it works compared to partial breast radiation therapy in treating women who have undergone surgery for ductal carcinoma in situ or stage I or stage II breast cancer.
Detailed Description: OBJECTIVES: Primary * Compare local tumor control in women with ductal carcinoma in situ or stage I or II breast cancer treated with adjuvant whole breast vs partial breast irradiation following lumpectomy. Secondary * Compare overall survival, recurrence-free survival, and distant disease-free survival in patients treated with these regimens. * Compare the cosmetic result in patients treated with these regimens. * Compare fatigue and treatment-related symptoms in patients treated with these regimens. * Compare perceived convenience of care in patients treated with these regimens. * Compare acute and late toxic effects of these regimens in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to disease stage (ductal carcinoma in situ \[DCIS\] only vs invasive and node negative vs invasive with 1-3 positive nodes), menopausal status (premenopausal vs postmenopausal), hormone receptor status (estrogen receptor \[ER\]-positive and/or progesterone receptor \[PR\]-positive vs ER-negative and PR-negative), intention to receive chemotherapy (yes vs no). Patients are randomized to 1 of 2 treatment arms. (Patients who are 50 years of age and over with DCIS regardless of hormone receptor status AND patients with invasive breast cancer meeting all of the following criteria: ≥ 50 years of age, node-negative, and hormone-receptor positive status will not be enrolled in study after 12/30/2006.) * Group 1: Patients undergo whole-breast irradiation (WBI) once daily, 5 days a week, for 5-7 weeks. * Group 2: Patients undergo partial-breast irradiation (PBI) twice daily on 5 days over a period of 5-10 days. This may be delivered by multi-catheter brachytherapy, single-entry intracavitary brachytherapy, or 3-D conformal radiotherapy. Patients in both arms may receive adjuvant chemotherapy at least 2 weeks prior to initiation of WBI OR at least 2 weeks after completion of PBI at the discretion of the treating physician. Patients with ER-positive or PR-positive tumors may also receive hormonal therapy, beginning 3-12 weeks after completion of adjuvant chemotherapy (or before, during, or after completion of WBI or PBI for patients not receiving adjuvant chemotherapy) and continuing for at least 5 years. After completion of study treatment, patients are followed at 1 and 6 months, every 6 months for 4.5 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 4,300 patients (2,150 per treatment arm) will be accrued for this study within 4.6 years. Note: Accrual closed on April 16, 2013, following approval of the Data Monitoring Committee to reduce the sample size from 4,300 to 4,214 patients.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
UAB Comprehensive Cancer Center, Birmingham, Alabama, United States
Arizona Center for Cancer Care - Peoria, Peoria, Arizona, United States
Arizona Oncology Services Foundation, Phoenix, Arizona, United States
Arizona Breast Cancer Specialists, Scottsdale, Arizona, United States
Mayo Clinic Scottsdale, Scottsdale, Arizona, United States
Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States
Auburn Radiation Oncology, Auburn, California, United States
Alta Bates Summit Comprehensive Cancer Center, Berkeley, California, United States
Peninsula Medical Center, Burlingame, California, United States
Radiation Oncology Centers - Cameron Park, Cameron Park, California, United States
Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael, California, United States
Enloe Cancer Center at Enloe Medical Center, Chico, California, United States
Cancer Care Center at John Muir Health - Concord Campus, Concord, California, United States
City of Hope Comprehensive Cancer Center, Duarte, California, United States
North Bay Cancer Center, Fairfield, California, United States
California Cancer Center - Woodward Park Office, Fresno, California, United States
Kaiser Permanente Medical Center - Hayward, Hayward, California, United States
Rebecca and John Moores UCSD Cancer Center, La Jolla, California, United States
Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States
Community Hospital of the Monterey Peninsula Comprehensive Cancer Center, Monterey, California, United States
Sutter Health - Western Division Cancer Research Group, Novato, California, United States
CCOP - Bay Area Tumor Institute, Oakland, California, United States
St. Joseph Hospital Regional Cancer Center - Orange, Orange, California, United States
Desert Regional Medical Center Comprehensive Cancer Center, Palm Springs, California, United States
Feather River Hospital Cancer Center, Paradise, California, United States
Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona, California, United States
Mercy Regional Cancer Center at Mercy Medical Center, Redding, California, United States
Radiation Oncology Center - Roseville, Roseville, California, United States
Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento, California, United States
University of California Davis Cancer Center, Sacramento, California, United States
Mercy General Hospital, Sacramento, California, United States
Kaiser Permanente Medical Office -Vandever Medical Office, San Diego, California, United States
Sharp Memorial Hospital Cancer Center, San Diego, California, United States
California Pacific Medical Center - California Campus, San Francisco, California, United States
Doctors Medical Center - San Pablo Campus, San Pablo, California, United States
Stanford Cancer Center, Stanford, California, United States
Solano Radiation Oncology Center, Vacaville, California, United States
Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States
Sutter Solano Medical Center, Vallejo, California, United States
John Muir/Mt. Diablo Comprehensive Cancer Center, Walnut Creek, California, United States
Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital, Whittier, California, United States
Aurora Presbyterian Hospital, Aurora, Colorado, United States
University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado, United States
Boulder Community Hospital, Boulder, Colorado, United States
Memorial Hospital Cancer Center - Colorado Springs, Colorado Springs, Colorado, United States
Penrose Cancer Center at Penrose Hospital, Colorado Springs, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
Poudre Valley Radiation Oncology, Fort Collins, Colorado, United States
North Colorado Medical Center, Greeley, Colorado, United States
Sky Ridge Medical Center, Lone Tree, Colorado, United States
Hope Cancer Care Center at Longmont United Hospital, Longmont, Colorado, United States
McKee Medical Center, Loveland, Colorado, United States
St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States
North Suburban Medical Center, Thornton, Colorado, United States
Bridgeport Hospital, Bridgeport, Connecticut, United States
Helen and Harry Gray Cancer Center at Hartford Hospital, Hartford, Connecticut, United States
Hospital of Saint Raphael, New Haven, Connecticut, United States
Yale Cancer Center, New Haven, Connecticut, United States
Norwalk Hospital, Norwalk, Connecticut, United States
Connecticut Oncology & Hematology - Torrington, Torrington, Connecticut, United States
CCOP - Christiana Care Health Services, Newark, Delaware, United States
Washington Cancer Institute at Washington Hospital Center, Washington, District of Columbia, United States
Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus, Boca Raton, Florida, United States
University of Florida Shands Cancer Center, Gainesville, Florida, United States
Integrated Community Oncology Network, Jacksonville Beach, Florida, United States
Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States
Integrated Community Oncology Network at Southside Cancer Center, Jacksonville, Florida, United States
Mayo Clinic - Jacksonville, Jacksonville, Florida, United States
Baptist Medical Center South, Jacksonville, Florida, United States
Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter, Florida, United States
Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland, Florida, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
Integrated Community Oncology Network - Orange Park, Orange Park, Florida, United States
Florida Cancer Center - Palatka, Palatka, Florida, United States
Flagler Cancer Center, Saint Augustine, Florida, United States
Northside Hospital Cancer Center, Atlanta, Georgia, United States
CCOP - Atlanta Regional, Atlanta, Georgia, United States
Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur, Georgia, United States
Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta, Georgia, United States
Cancer Research Center of Hawaii, Honolulu, Hawaii, United States
Queen's Cancer Institute at Queen's Medical Center, Honolulu, Hawaii, United States
Straub Clinic and Hospital, Incorporated, Honolulu, Hawaii, United States
Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise, Idaho, United States
Kootenai Cancer Center - Coeur d'Alene, Coeur d'Alene, Idaho, United States
Rush-Copley Cancer Care Center, Aurora, Illinois, United States
Good Shepherd Hospital, Barrington, Illinois, United States
Illinois CancerCare - Bloomington, Bloomington, Illinois, United States
Illinois CancerCare - Canton, Canton, Illinois, United States
Illinois CancerCare - Carthage, Carthage, Illinois, United States
Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States
Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States
Alexian Brothers Radiation Oncology, Elk Grove Village, Illinois, United States
Illinois CancerCare - Eureka, Eureka, Illinois, United States
Illinois CancerCare - Cottage, Galesburg, Illinois, United States
Illinois CancerCare - Galesburg, Galesburg, Illinois, United States
Illinois CancerCare - Havana, Havana, Illinois, United States
Illinois CancerCare - Kewanee Clinic, Kewanee, Illinois, United States
Illinois CancerCare - Macomb, Macomb, Illinois, United States
Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States
Trinity Cancer Center at Trinity Medical Center - 7th Street Campus, Moline, Illinois, United States
Illinois CancerCare - Monmouth, Monmouth, Illinois, United States
OSF Holy Family Medical Center, Monmouth, Illinois, United States
Edward Hospital Cancer Center, Naperville, Illinois, United States
Community Cancer Center, Normal, Illinois, United States
Illinois CancerCare - Community Cancer Center, Normal, Illinois, United States
Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa, Illinois, United States
Advocate Lutheran General Cancer Care Center, Park Ridge, Illinois, United States
Cancer Treatment Center at Pekin Hospital, Pekin, Illinois, United States
Illinois CancerCare - Pekin, Pekin, Illinois, United States
OSF St. Francis Medical Center, Peoria, Illinois, United States
CCOP - Illinois Oncology Research Association, Peoria, Illinois, United States
Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria, Illinois, United States
Methodist Medical Center of Illinois, Peoria, Illinois, United States
Illinois CancerCare - Peru, Peru, Illinois, United States
Illinois CancerCare - Princeton, Princeton, Illinois, United States
Illinois CancerCare - Spring Valley, Spring Valley, Illinois, United States
Cancer Institute at St. John's Hospital, Springfield, Illinois, United States
CCOP - Carle Cancer Center, Urbana, Illinois, United States
Central Dupage Cancer Center, Warrenville, Illinois, United States
Saint John's Cancer Center at Saint John's Medical Center, Anderson, Indiana, United States
Elkhart General Hospital, Elkhart, Indiana, United States
Radiation Oncology Associates Southwest, Fort Wayne, Indiana, United States
Parkview Regional Cancer Center at Parkview Health, Fort Wayne, Indiana, United States
Center for Cancer Care at Goshen General Hospital, Goshen, Indiana, United States
Methodist Cancer Center at Methodist Hospital, Indianapolis, Indiana, United States
Central Indiana Cancer Centers - East, Indianapolis, Indiana, United States
St. Vincent Indianapolis Hospital, Indianapolis, Indiana, United States
Memorial Hospital of South Bend, South Bend, Indiana, United States
Genesis Regional Cancer Center at Genesis Medical Center, Davenport, Iowa, United States
John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States
Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States
CCOP - Kansas City, Prairie Village, Kansas, United States
Central Baptist Hospital, Lexington, Kentucky, United States
Lucille P. Markey Cancer Center at University of Kentucky, Lexington, Kentucky, United States
James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States
Louisville Oncology at Norton Cancer Institute - Louisville, Louisville, Kentucky, United States
Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge, Louisiana, United States
Ochsner Health Center - Bluebonnet, Baton Rouge, Louisiana, United States
CCOP - Ochsner, New Orleans, Louisiana, United States
CancerCare of Maine at Eastern Maine Medical Center, Bangor, Maine, United States
Central Maine Comprehensive Cancer Center at Central Maine Medical Center, Lewiston, Maine, United States
DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis, Maryland, United States
Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States
St. Agnes Hospital Cancer Center, Baltimore, Maryland, United States
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States
Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore, Maryland, United States
Central Maryland Oncology Center, Columbia, Maryland, United States
Shore Regional Cancer Center at Memorial Hospital - Easton, Easton, Maryland, United States
Union Hospital of Cecil County, Elkton, Maryland, United States
Peninsula Regional Medical Center, Salisbury, Maryland, United States
Holy Cross Hospital, Silver Spring, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Boston University Cancer Research Center, Boston, Massachusetts, United States
Lahey Clinic Medical Center - Burlington, Burlington, Massachusetts, United States
NSMC Cancer Center - Peabody, Danvers, Massachusetts, United States
MetroWest Medical Center - Framingham Union Hospital, Framingham, Massachusetts, United States
Cape Cod Hospital, Hyannis, Massachusetts, United States
Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, United States
Battle Creek Health System Cancer Care Center, Battle Creek, Michigan, United States
Henry Ford Macomb Hospital, Clinton Township, Michigan, United States
Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States
Josephine Ford Cancer Center at Henry Ford Hospital, Detroit, Michigan, United States
Genesys Hurley Cancer Institute, Flint, Michigan, United States
McLaren Cancer Institute, Flint, Michigan, United States
Butterworth Hospital at Spectrum Health, Grand Rapids, Michigan, United States
CCOP - Grand Rapids, Grand Rapids, Michigan, United States
Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
Breslin Cancer Center at Ingham Regional Medical Center, Lansing, Michigan, United States
St. Joseph Mercy Oakland, Pontiac, Michigan, United States
William Beaumont Hospital - Royal Oak Campus, Royal Oak, Michigan, United States
Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan, United States
St. John Macomb Hospital, Warren, Michigan, United States
MeritCare Bemidji, Bemidji, Minnesota, United States
Fairview Ridges Hospital, Burnsville, Minnesota, United States
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States
St. Luke's Hospital Cancer Care Center, Duluth, Minnesota, United States
Fairview Southdale Hospital, Edina, Minnesota, United States
Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States
Immanuel St. Joseph's, Mankato, Minnesota, United States
Minnesota Oncology - Maplewood, Maplewood, Minnesota, United States
Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States
Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States
Mayo Clinic Cancer Center, Rochester, Minnesota, United States
CentraCare Clinic - River Campus, Saint Cloud, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States
Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States
United Hospital, Saint Paul, Minnesota, United States
Ridgeview Medical Center, Waconia, Minnesota, United States
Minnesota Oncology - Woodbury, Woodbury, Minnesota, United States
University of Mississippi Cancer Clinic, Jackson, Mississippi, United States
Kansas City Cancer Centers - North, Kansas City, Missouri, United States
Billings Clinic - Downtown, Billings, Montana, United States
Great Falls Clinic - Main Facility, Great Falls, Montana, United States
Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States
Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States
Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney, Nebraska, United States
Methodist Estabrook Cancer Center, Omaha, Nebraska, United States
Immanuel Medical Center, Omaha, Nebraska, United States
Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska, United States
Creighton University Medical Center, Omaha, Nebraska, United States
CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States
Renown Institute for Cancer at Renown Regional Medical Center, Reno, Nevada, United States
Saint Mary's Regional Medical Center, Reno, Nevada, United States
Payson Center for Cancer Care at Concord Hospital, Concord, New Hampshire, United States
Seacoast Cancer Center at Wentworth - Douglass Hospital, Dover, New Hampshire, United States
Center for Cancer Care at Exeter Hospital, Exeter, New Hampshire, United States
Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States
Elliot Regional Cancer Center at Elliot Hospital, Manchester, New Hampshire, United States
Memorial Sloan-Kettering Cancer Center - Basking Ridge, Basking Ridge, New Jersey, United States
Trinitas Comprehensive Cancer Center at Trinitas Hospital, Elizabeth, New Jersey, United States
Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center, Englewood, New Jersey, United States
St. Barnabas Medical Center Cancer Center, Livingston, New Jersey, United States
Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, United States
Saint Peter's University Hospital, New Brunswick, New Jersey, United States
Newark Beth Israel Medical Center, Newark, New Jersey, United States
Frederick R. and Betty M. Smith Cancer Treatment Center, Sparta, New Jersey, United States
J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River, New Jersey, United States
St. Francis Regional Cancer Center, Trenton, New Jersey, United States
Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States
University of New Mexico Cancer Center, Albuquerque, New Mexico, United States
New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany, New York, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Sands Cancer Center, Canandaigua, New York, United States
Memorial Sloan-Kettering Cancer Center, Commack, New York, United States
Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital, Cooperstown, New York, United States
CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States
Cayuga Medical Center of Ithaca, Ithaca, New York, United States
Queens Cancer Center of Queens Hospital, Jamaica, New York, United States
CCOP - North Shore University Hospital, Manhasset, New York, United States
Long Island Jewish Medical Center, New Hyde Park, New York, United States
Hudson Valley Oncology Associates, Poughkeepsie, New York, United States
Saint Francis Hospital Cancer Center, Poughkeepsie, New York, United States
Highland Hospital of Rochester, Rochester, New York, United States
Lipson Cancer and Blood Center at Rochester General Hospital, Rochester, New York, United States
University Radiation Oncology at Parkridge Hospital, Rochester, New York, United States
James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States
Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center, Sleepy Hollow, New York, United States
SUNY Upstate Medical University Hospital, Syracuse, New York, United States
Mission Hospitals - Memorial Campus, Asheville, North Carolina, United States
Hope A Women's Cancer Center, Asheville, North Carolina, United States
Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, United States
Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, United States
Duke Cancer Institute, Durham, North Carolina, United States
Pardee Memorial Hospital, Hendersonville, North Carolina, United States
High Point Regional Hospital, High Point, North Carolina, United States
Cancer Centers of North Carolina - Raleigh, Raleigh, North Carolina, United States
Coastal Carolina Radiation Oncology Center, Wilmington, North Carolina, United States
Forsyth Regional Cancer Center at Forsyth Medical Center, Winston-Salem, North Carolina, United States
MeritCare Broadway, Fargo, North Dakota, United States
Altru Cancer Center at Altru Hospital, Grand Forks, North Dakota, United States
McDowell Cancer Center at Akron General Medical Center, Akron, Ohio, United States
Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio, United States
Barberton Citizens Hospital, Barberton, Ohio, United States
Aultman Cancer Center at Aultman Hospital, Canton, Ohio, United States
Case Comprehensive Cancer Center, Cleveland, Ohio, United States
Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland, Ohio, United States
Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States
Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States
CCOP - Columbus, Columbus, Ohio, United States
Cleveland Clinic Cancer Center, Independence, Ohio, United States
St. Rita's Medical Center, Lima, Ohio, United States
Lima Memorial Hospital, Lima, Ohio, United States
MedCentral - Mansfield Hospital, Mansfield, Ohio, United States
Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights, Ohio, United States
Community Hospital of Springfield and Clark County, Springfield, Ohio, United States
Flower Hospital Cancer Center, Sylvania, Ohio, United States
Medical University of Ohio Cancer Center, Toledo, Ohio, United States
St. Anne Mercy Hospital, Toledo, Ohio, United States
Cleveland Clinic - Wooster, Wooster, Ohio, United States
Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa, Oklahoma, United States
Clackamas Radiation Oncology Center, Clackamas, Oregon, United States
Willamette Valley Cancer Center - Eugene, Eugene, Oregon, United States
Three Rivers Community Hospital, Grants Pass, Oregon, United States
Legacy Mount Hood Medical Center, Gresham, Oregon, United States
Dubs Cancer Center at Rogue Valley Medical Center, Medford, Oregon, United States
Providence Cancer Center at PMCC, Medford, Oregon, United States
Providence Milwaukie Hospital, Milwaukie, Oregon, United States
Legacy Good Samaritan Hospital & Comprehensive Cancer Center, Portland, Oregon, United States
Providence Cancer Center at Providence Portland Medical Center, Portland, Oregon, United States
CCOP - Columbia River Oncology Program, Portland, Oregon, United States
Providence St. Vincent Medical Center, Portland, Oregon, United States
Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland, Oregon, United States
Knight Cancer Institute at Oregon Health and Science University, Portland, Oregon, United States
Salem Hospital Regional Cancer Care Services, Salem, Oregon, United States
Legacy Meridian Park Hospital, Tualatin, Oregon, United States
UPMC Cancer Center at Beaver Medical Center, Beaver, Pennsylvania, United States
St. Luke's Cancer Network at St. Luke's Hospital, Bethlehem, Pennsylvania, United States
Geisinger Cancer Institute at Geisinger Health, Danville, Pennsylvania, United States
Delaware County Regional Cancer Center at Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States
Northeast Radiation Oncology Center, Dunmore, Pennsylvania, United States
Regional Cancer Center - Erie, Erie, Pennsylvania, United States
PinnacleHealth Regional Cancer Center at Polyclinic Hospital, Harrisburg, Pennsylvania, United States
Intercommunity Cancer Center, Monroeville, Pennsylvania, United States
Norristown Regional Cancer Center, Norristown, Pennsylvania, United States
Drexel University College of Medicine - Center City Hahnemann Campus, Philadelphia, Pennsylvania, United States
Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States
Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania, United States
Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia, Pennsylvania, United States
Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, Pennsylvania, United States
UPMC - Shadyside, Pittsburgh, Pennsylvania, United States
Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States
McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading, Pennsylvania, United States
Mount Nittany Medical Center, State College, Pennsylvania, United States
Crozer-Chester Medical Center, Upland, Pennsylvania, United States
Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
York Cancer Center at Apple Hill Medical Center, York, Pennsylvania, United States
Rhode Island Hospital Comprehensive Cancer Center, Providence, Rhode Island, United States
Northmain Radiation Oncology, Providence, Rhode Island, United States
Roper St. Francis Cancer Center at Roper Hospital, Charleston, South Carolina, United States
Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States
Georgetown Memorial Hospital, Georgetown, South Carolina, United States
Rapid City Regional Hospital, Rapid City, South Dakota, United States
Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States
Thompson Cancer Survival Center, Knoxville, Tennessee, United States
Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States
Texas Oncology, PA at Harris Center HEB, Bedford, Texas, United States
Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States
Texas Oncology, PA at Texas Cancer Center - Denton South, Denton, Texas, United States
Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth, Texas, United States
M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States
Baylor Medical Center at Irving, Irving, Texas, United States
Texas Oncology, PA at Lake Vista Cancer Center, Lewisville, Texas, United States
Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States
Texas Oncology, PA at Texas Cancer Center Round Rock, Round Rock, Texas, United States
Cancer Care Centers of South Texas - Northeast, San Antonio, Texas, United States
University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States
Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman, Texas, United States
Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land, Texas, United States
Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States
Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States
Utah Valley Regional Medical Center - Provo, Provo, Utah, United States
Dixie Regional Medical Center - East Campus, Saint George, Utah, United States
Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah, United States
Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States
LDS Hospital, Salt Lake City, Utah, United States
Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States
University of Virginia Cancer Center, Charlottesville, Virginia, United States
Naval Medical Center - Portsmouth, Portsmouth, Virginia, United States
Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States
St. Joseph Cancer Center, Bellingham, Washington, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States
Providence Cancer Center at Sacred Heart Medical Center, Spokane, Washington, United States
Southwest Washington Medical Center Cancer Center, Vancouver, Washington, United States
West Virginia University Health Sciences Center - Charleston, Charleston, West Virginia, United States
St. Mary's Regional Cancer Center at St. Mary's Medical Center, Huntington, West Virginia, United States
Schiffler Cancer Center at Wheeling Hospital, Wheeling, West Virginia, United States
Center for Cancer Treatment & Prevention at Sacred Heart Hospital, Eau Claire, Wisconsin, United States
St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States
Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center, Green Bay, Wisconsin, United States
Franciscan Skemp Healthcare - La Crosse Campus, La Crosse, Wisconsin, United States
Dean Medical Center - Madison, Madison, Wisconsin, United States
University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, United States
Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, United States
Community Memorial Hospital Cancer Care Center, Menomonee Falls, Wisconsin, United States
Columbia Saint Mary's Hospital - Ozaukee, Mequon, Wisconsin, United States
Columbia-Saint Mary's Cancer Care Center, Milwaukee, Wisconsin, United States
Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, United States
Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States
Regional Cancer Center at Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States
All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine, Wisconsin, United States
Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin, United States
Aurora Medical Center, Summit, Wisconsin, United States
Waukesha Memorial Hospital Regional Cancer Center, Waukesha, Wisconsin, United States
University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau, Wisconsin, United States
West Allis Memorial Hospital, West Allis, Wisconsin, United States
Diagnostic and Treatment Center, Weston, Wisconsin, United States
Cross Cancer Institute at University of Alberta, Edmonton, Alberta, Canada
British Columbia Cancer Agency - Vancouver Island Centre, Victoria, British Columbia, Canada
CancerCare Manitoba, Winnipeg, Manitoba, Canada
London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada
Odette Cancer Centre at Sunnybrook, Toronto, Ontario, Canada
Hopital Notre-Dame du CHUM, Montreal, Quebec, Canada
Royal Victoria Hospital - Montreal, Montreal, Quebec, Canada
Montreal General Hospital, Montreal, Quebec, Canada
Jewish General Hospital - Montreal, Montreal, Quebec, Canada
Hopital du Saint-Sacrement - Quebec, Quebec City, Quebec, Canada
Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon, Saskatchewan, Canada
University College Hospital, Galway, , Ireland
Tel-Aviv Sourasky Medical Center, Tel Aviv, , Israel
Name: Norman Wolmark, MD
Affiliation: NSABP Foundation Inc
Role: PRINCIPAL_INVESTIGATOR