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Spots Global Cancer Trial Database for SWOG-9342 Chemotherapy in Treating Women Enrolled in the SWOG-8897 Clinical Trial

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Trial Identification

Brief Title: SWOG-9342 Chemotherapy in Treating Women Enrolled in the SWOG-8897 Clinical Trial

Official Title: A STUDY OF THE LATE CARDIAC EFFECTS OF TWO DIFFERENT ADJUVANT CHEMOTHERAPY REGIMENTS IN WOMEN WITH NODE NEGATIVE BREAST CANCER TREATED ON SWOG-8897

Study ID: NCT00002900

Study Description

Brief Summary: RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: This clinical trial is studying the effect of chemotherapy on heart function in treating women who have breast cancer with negative axillary lymph nodes and who are undergoing treatment on the SWOG-8897 clinical trial.

Detailed Description: OBJECTIVES: * Compare the frequency of subclinical congestive heart failure by measuring resting MUGA at 5-8 and 10-11 years after randomization in women receiving adjuvant chemotherapy with cyclophosphamide, methotrexate, and fluorouracil or cyclophosphamide, doxorubicin, and fluorouracil on protocol SWOG-8897. * Estimate the frequency of late cardiac effects (congestive heart failure, cardiac ischemic events, and clinical symptoms) in these patients treated with these regimens. * Monitor prospectively the incidence of annual cardiac events between the fifth and tenth year after randomization of these patients to these regimens. OUTLINE: This is a multicenter study. The treating physician completes patient cardiovascular and routine history and physical examination questionnaires at baseline and yearly. Patients undergo resting MUGA scans at 5-8 and 10-11 years after registration on protocol SWOG-8897. The first scan must be performed within 3 months prior to enrollment or within 1 month after registration on the current study, and the second scan must be done in the tenth year of follow-up and within 3 months prior to enrollment or 1 month from the anniversary of registration on the current study. PROJECTED ACCRUAL: A total of 420 patients will be accrued for this study. After initial accrual is completed, approximately 50 additional patients will be accrued at 10 years.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

MBCCOP - Gulf Coast, Mobile, Alabama, United States

CCOP - Western Regional, Arizona, Phoenix, Arizona, United States

Veterans Affairs Medical Center - Phoenix (Carl T. Hayden), Phoenix, Arizona, United States

Veterans Affairs Medical Center - Tucson, Tucson, Arizona, United States

Arizona Cancer Center at University of Arizona Health Sciences Center, Tucson, Arizona, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Veterans Affairs Medical Center - Little Rock (McClellan), Little Rock, Arkansas, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Veterans Affairs Medical Center - Long Beach, Long Beach, California, United States

USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles, California, United States

Veterans Affairs Medical Center - West Los Angeles, Los Angeles, California, United States

Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, California, United States

Veterans Affairs Outpatient Clinic - Martinez, Martinez, California, United States

CCOP - Bay Area Tumor Institute, Oakland, California, United States

Chao Family Comprehensive Cancer Center, Orange, California, United States

University of California Davis Cancer Center, Sacramento, California, United States

UCSF Comprehensive Cancer Center, San Francisco, California, United States

CCOP - Santa Rosa Memorial Hospital, Santa Rosa, California, United States

David Grant Medical Center, Travis Air Force Base, California, United States

University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver, Colorado, United States

Veterans Affairs Medical Center - Denver, Denver, Colorado, United States

MBCCOP - Howard University Cancer Center, Washington, District of Columbia, United States

CCOP - Atlanta Regional, Atlanta, Georgia, United States

Dwight David Eisenhower Army Medical Center, Fort Gordon, Georgia, United States

Cancer Research Center of Hawaii, Honolulu, Hawaii, United States

MBCCOP - Hawaii, Honolulu, Hawaii, United States

Tripler Army Medical Center, Honolulu, Hawaii, United States

MBCCOP - University of Illinois at Chicago, Chicago, Illinois, United States

Veterans Affairs Medical Center - Chicago (Westside Hospital), Chicago, Illinois, United States

CCOP - Central Illinois, Decatur, Illinois, United States

Veterans Affairs Medical Center - Hines (Hines Junior VA Hospital), Hines, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

University of Kansas Medical Center, Kansas City, Kansas, United States

CCOP - Wichita, Wichita, Kansas, United States

Veterans Affairs Medical Center - Wichita, Wichita, Kansas, United States

Veterans Affairs Medical Center - Lexington, Lexington, Kentucky, United States

Albert B. Chandler Medical Center, University of Kentucky, Lexington, Kentucky, United States

MBCCOP - LSU Health Sciences Center, New Orleans, Louisiana, United States

Tulane University School of Medicine, New Orleans, Louisiana, United States

Louisiana State University Health Sciences Center - Shreveport, Shreveport, Louisiana, United States

Veterans Affairs Medical Center - Shreveport, Shreveport, Louisiana, United States

Boston Medical Center, Boston, Massachusetts, United States

Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain, Massachusetts, United States

Veterans Affairs Medical Center - Ann Arbor, Ann Arbor, Michigan, United States

CCOP - Michigan Cancer Research Consortium, Ann Arbor, Michigan, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

Veterans Affairs Medical Center - Detroit, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

CCOP - Grand Rapids, Grand Rapids, Michigan, United States

CCOP - Beaumont, Royal Oak, Michigan, United States

Providence Hospital - Southfield, Southfield, Michigan, United States

CCOP - Duluth, Duluth, Minnesota, United States

Veterans Affairs Medical Center - Biloxi, Biloxi, Mississippi, United States

University of Mississippi Medical Center, Jackson, Mississippi, United States

Veterans Affairs Medical Center - Jackson, Jackson, Mississippi, United States

Veterans Affairs Medical Center - Kansas City, Kansas City, Missouri, United States

CCOP - Kansas City, Kansas City, Missouri, United States

St. Louis University Health Sciences Center, Saint Louis, Missouri, United States

CCOP - St. Louis-Cape Girardeau, Saint Louis, Missouri, United States

CCOP - Cancer Research for the Ozarks, Springfield, Missouri, United States

CCOP - Montana Cancer Consortium, Billings, Montana, United States

Veterans Affairs Medical Center - Albuquerque, Albuquerque, New Mexico, United States

MBCCOP - University of New Mexico HSC, Albuquerque, New Mexico, United States

Veterans Affairs Medical Center - Albany, Albany, New York, United States

Herbert Irving Comprehensive Cancer Center at Columbia University, New York, New York, United States

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States

CCOP - Southeast Cancer Control Consortium, Winston-Salem, North Carolina, United States

Veterans Affairs Medical Center - Cincinnati, Cincinnati, Ohio, United States

Barrett Cancer Center, Cincinnati, Ohio, United States

Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States

CCOP - Columbus, Columbus, Ohio, United States

Veterans Affairs Medical Center - Dayton, Dayton, Ohio, United States

CCOP - Dayton, Dayton, Ohio, United States

CCOP - Toledo Community Hospital, Toledo, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Veterans Affairs Medical Center - Oklahoma City, Oklahoma City, Oklahoma, United States

Oregon Cancer Institute, Portland, Oregon, United States

Veterans Affairs Medical Center - Portland, Portland, Oregon, United States

CCOP - Columbia River Oncology Program, Portland, Oregon, United States

Veterans Affairs Medical Center - Charleston, Charleston, South Carolina, United States

Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States

CCOP - Greenville, Greenville, South Carolina, United States

CCOP - Upstate Carolina, Spartanburg, South Carolina, United States

University of Tennessee Cancer Institute, Memphis, Tennessee, United States

Danville Radiation Therapy Center, Memphis, Tennessee, United States

Harrington Cancer Center, Amarillo, Texas, United States

Veterans Affairs Medical Center - Amarillo, Amarillo, Texas, United States

Veterans Affairs Medical Center - Dallas, Dallas, Texas, United States

Brooke Army Medical Center, Fort Sam Houston, Texas, United States

University of Texas Medical Branch, Galveston, Texas, United States

Veterans Affairs Medical Center - Houston, Houston, Texas, United States

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Veterans Affairs Medical Center - San Antonio (Murphy), San Antonio, Texas, United States

Veterans Affairs Medical Center - Temple, Temple, Texas, United States

CCOP - Scott and White Hospital, Temple, Texas, United States

Huntsman Cancer Institute, Salt Lake City, Utah, United States

Veterans Affairs Medical Center - Salt Lake City, Salt Lake City, Utah, United States

Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States

MBCCOP - Massey Cancer Center, Richmond, Virginia, United States

CCOP - Virginia Mason Research Center, Seattle, Washington, United States

Swedish Cancer Institute at Swedish Medical Center - First Hill Campus, Seattle, Washington, United States

Veterans Affairs Medical Center - Seattle, Seattle, Washington, United States

CCOP - Northwest, Tacoma, Washington, United States

Madigan Army Medical Center, Tacoma, Washington, United States

Contact Details

Name: Patricia A. Ganz, MD

Affiliation: Jonsson Comprehensive Cancer Center

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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