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Spots Global Cancer Trial Database for Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer

Official Title: A Randomized Phase III Study of Conventional Whole Breast Irradiation (WBI) Versus Partial Breast Irradiation (PBI) for Women With Stage 0, I, or II Breast Cancer

Study ID: NCT00103181

Conditions

Breast Cancer

Study Description

Brief Summary: RATIONALE: Radiation therapy uses high-energy x-rays to kill tumor cells. Giving radiation therapy in different ways may kill any tumor cells that remain after surgery. It is not yet known whether whole breast radiation therapy is more effective than partial breast radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial is studying whole breast radiation therapy to see how well it works compared to partial breast radiation therapy in treating women who have undergone surgery for ductal carcinoma in situ or stage I or stage II breast cancer.

Detailed Description: OBJECTIVES: Primary * Compare local tumor control in women with ductal carcinoma in situ or stage I or II breast cancer treated with adjuvant whole breast vs partial breast irradiation following lumpectomy. Secondary * Compare overall survival, recurrence-free survival, and distant disease-free survival in patients treated with these regimens. * Compare the cosmetic result in patients treated with these regimens. * Compare fatigue and treatment-related symptoms in patients treated with these regimens. * Compare perceived convenience of care in patients treated with these regimens. * Compare acute and late toxic effects of these regimens in these patients. OUTLINE: This is a randomized, multicenter study. Patients are stratified according to disease stage (ductal carcinoma in situ \[DCIS\] only vs invasive and node negative vs invasive with 1-3 positive nodes), menopausal status (premenopausal vs postmenopausal), hormone receptor status (estrogen receptor \[ER\]-positive and/or progesterone receptor \[PR\]-positive vs ER-negative and PR-negative), intention to receive chemotherapy (yes vs no). Patients are randomized to 1 of 2 treatment arms. (Patients who are 50 years of age and over with DCIS regardless of hormone receptor status AND patients with invasive breast cancer meeting all of the following criteria: ≥ 50 years of age, node-negative, and hormone-receptor positive status will not be enrolled in study after 12/30/2006.) * Group 1: Patients undergo whole-breast irradiation (WBI) once daily, 5 days a week, for 5-7 weeks. * Group 2: Patients undergo partial-breast irradiation (PBI) twice daily on 5 days over a period of 5-10 days. This may be delivered by multi-catheter brachytherapy, single-entry intracavitary brachytherapy, or 3-D conformal radiotherapy. Patients in both arms may receive adjuvant chemotherapy at least 2 weeks prior to initiation of WBI OR at least 2 weeks after completion of PBI at the discretion of the treating physician. Patients with ER-positive or PR-positive tumors may also receive hormonal therapy, beginning 3-12 weeks after completion of adjuvant chemotherapy (or before, during, or after completion of WBI or PBI for patients not receiving adjuvant chemotherapy) and continuing for at least 5 years. After completion of study treatment, patients are followed at 1 and 6 months, every 6 months for 4.5 years, and then annually thereafter. PROJECTED ACCRUAL: A total of 4,300 patients (2,150 per treatment arm) will be accrued for this study within 4.6 years. Note: Accrual closed on April 16, 2013, following approval of the Data Monitoring Committee to reduce the sample size from 4,300 to 4,214 patients.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

UAB Comprehensive Cancer Center, Birmingham, Alabama, United States

Arizona Center for Cancer Care - Peoria, Peoria, Arizona, United States

Arizona Oncology Services Foundation, Phoenix, Arizona, United States

Arizona Breast Cancer Specialists, Scottsdale, Arizona, United States

Mayo Clinic Scottsdale, Scottsdale, Arizona, United States

Arkansas Cancer Research Center at University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Auburn Radiation Oncology, Auburn, California, United States

Alta Bates Summit Comprehensive Cancer Center, Berkeley, California, United States

Peninsula Medical Center, Burlingame, California, United States

Radiation Oncology Centers - Cameron Park, Cameron Park, California, United States

Mercy Cancer Center at Mercy San Juan Medical Center, Carmichael, California, United States

Enloe Cancer Center at Enloe Medical Center, Chico, California, United States

Cancer Care Center at John Muir Health - Concord Campus, Concord, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

North Bay Cancer Center, Fairfield, California, United States

California Cancer Center - Woodward Park Office, Fresno, California, United States

Kaiser Permanente Medical Center - Hayward, Hayward, California, United States

Rebecca and John Moores UCSD Cancer Center, La Jolla, California, United States

Jonsson Comprehensive Cancer Center at UCLA, Los Angeles, California, United States

Community Hospital of the Monterey Peninsula Comprehensive Cancer Center, Monterey, California, United States

Sutter Health - Western Division Cancer Research Group, Novato, California, United States

CCOP - Bay Area Tumor Institute, Oakland, California, United States

St. Joseph Hospital Regional Cancer Center - Orange, Orange, California, United States

Desert Regional Medical Center Comprehensive Cancer Center, Palm Springs, California, United States

Feather River Hospital Cancer Center, Paradise, California, United States

Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona, California, United States

Mercy Regional Cancer Center at Mercy Medical Center, Redding, California, United States

Radiation Oncology Center - Roseville, Roseville, California, United States

Radiological Associates of Sacramento Medical Group, Incorporated, Sacramento, California, United States

University of California Davis Cancer Center, Sacramento, California, United States

Mercy General Hospital, Sacramento, California, United States

Kaiser Permanente Medical Office -Vandever Medical Office, San Diego, California, United States

Sharp Memorial Hospital Cancer Center, San Diego, California, United States

California Pacific Medical Center - California Campus, San Francisco, California, United States

Doctors Medical Center - San Pablo Campus, San Pablo, California, United States

Stanford Cancer Center, Stanford, California, United States

Solano Radiation Oncology Center, Vacaville, California, United States

Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States

Sutter Solano Medical Center, Vallejo, California, United States

John Muir/Mt. Diablo Comprehensive Cancer Center, Walnut Creek, California, United States

Ruby L. Golleher Cancer Program at Presbyterian Intercommunity Hospital, Whittier, California, United States

Aurora Presbyterian Hospital, Aurora, Colorado, United States

University of Colorado Cancer Center at UC Health Sciences Center, Aurora, Colorado, United States

Boulder Community Hospital, Boulder, Colorado, United States

Memorial Hospital Cancer Center - Colorado Springs, Colorado Springs, Colorado, United States

Penrose Cancer Center at Penrose Hospital, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

Poudre Valley Radiation Oncology, Fort Collins, Colorado, United States

North Colorado Medical Center, Greeley, Colorado, United States

Sky Ridge Medical Center, Lone Tree, Colorado, United States

Hope Cancer Care Center at Longmont United Hospital, Longmont, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

St. Mary - Corwin Regional Medical Center, Pueblo, Colorado, United States

North Suburban Medical Center, Thornton, Colorado, United States

Bridgeport Hospital, Bridgeport, Connecticut, United States

Helen and Harry Gray Cancer Center at Hartford Hospital, Hartford, Connecticut, United States

Hospital of Saint Raphael, New Haven, Connecticut, United States

Yale Cancer Center, New Haven, Connecticut, United States

Norwalk Hospital, Norwalk, Connecticut, United States

Connecticut Oncology & Hematology - Torrington, Torrington, Connecticut, United States

CCOP - Christiana Care Health Services, Newark, Delaware, United States

Washington Cancer Institute at Washington Hospital Center, Washington, District of Columbia, United States

Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital - Main Campus, Boca Raton, Florida, United States

University of Florida Shands Cancer Center, Gainesville, Florida, United States

Integrated Community Oncology Network, Jacksonville Beach, Florida, United States

Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States

Integrated Community Oncology Network at Southside Cancer Center, Jacksonville, Florida, United States

Mayo Clinic - Jacksonville, Jacksonville, Florida, United States

Baptist Medical Center South, Jacksonville, Florida, United States

Ella Milbank Foshay Cancer Center at Jupiter Medical Center, Jupiter, Florida, United States

Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland, Florida, United States

CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States

Integrated Community Oncology Network - Orange Park, Orange Park, Florida, United States

Florida Cancer Center - Palatka, Palatka, Florida, United States

Flagler Cancer Center, Saint Augustine, Florida, United States

Northside Hospital Cancer Center, Atlanta, Georgia, United States

CCOP - Atlanta Regional, Atlanta, Georgia, United States

Charles B. Eberhart Cancer Center at DeKalb Medical Center, Decatur, Georgia, United States

Kennestone Cancer Center at Wellstar Kennestone Hospital, Marietta, Georgia, United States

Cancer Research Center of Hawaii, Honolulu, Hawaii, United States

Queen's Cancer Institute at Queen's Medical Center, Honolulu, Hawaii, United States

Straub Clinic and Hospital, Incorporated, Honolulu, Hawaii, United States

Mountain States Tumor Institute at St. Luke's Regional Medical Center, Boise, Idaho, United States

Kootenai Cancer Center - Coeur d'Alene, Coeur d'Alene, Idaho, United States

Rush-Copley Cancer Care Center, Aurora, Illinois, United States

Good Shepherd Hospital, Barrington, Illinois, United States

Illinois CancerCare - Bloomington, Bloomington, Illinois, United States

Illinois CancerCare - Canton, Canton, Illinois, United States

Illinois CancerCare - Carthage, Carthage, Illinois, United States

Creticos Cancer Center at Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

Good Samaritan Cancer Care Center at Advocate Good Samaritan Hospital, Downers Grove, Illinois, United States

Alexian Brothers Radiation Oncology, Elk Grove Village, Illinois, United States

Illinois CancerCare - Eureka, Eureka, Illinois, United States

Illinois CancerCare - Cottage, Galesburg, Illinois, United States

Illinois CancerCare - Galesburg, Galesburg, Illinois, United States

Illinois CancerCare - Havana, Havana, Illinois, United States

Illinois CancerCare - Kewanee Clinic, Kewanee, Illinois, United States

Illinois CancerCare - Macomb, Macomb, Illinois, United States

Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood, Illinois, United States

Trinity Cancer Center at Trinity Medical Center - 7th Street Campus, Moline, Illinois, United States

Illinois CancerCare - Monmouth, Monmouth, Illinois, United States

OSF Holy Family Medical Center, Monmouth, Illinois, United States

Edward Hospital Cancer Center, Naperville, Illinois, United States

Community Cancer Center, Normal, Illinois, United States

Illinois CancerCare - Community Cancer Center, Normal, Illinois, United States

Oncology Hematology Associates of Central Illinois, PC - Ottawa, Ottawa, Illinois, United States

Advocate Lutheran General Cancer Care Center, Park Ridge, Illinois, United States

Cancer Treatment Center at Pekin Hospital, Pekin, Illinois, United States

Illinois CancerCare - Pekin, Pekin, Illinois, United States

OSF St. Francis Medical Center, Peoria, Illinois, United States

CCOP - Illinois Oncology Research Association, Peoria, Illinois, United States

Oncology Hematology Associates of Central Illinois, PC - Peoria, Peoria, Illinois, United States

Methodist Medical Center of Illinois, Peoria, Illinois, United States

Illinois CancerCare - Peru, Peru, Illinois, United States

Illinois CancerCare - Princeton, Princeton, Illinois, United States

Illinois CancerCare - Spring Valley, Spring Valley, Illinois, United States

Cancer Institute at St. John's Hospital, Springfield, Illinois, United States

CCOP - Carle Cancer Center, Urbana, Illinois, United States

Central Dupage Cancer Center, Warrenville, Illinois, United States

Saint John's Cancer Center at Saint John's Medical Center, Anderson, Indiana, United States

Elkhart General Hospital, Elkhart, Indiana, United States

Radiation Oncology Associates Southwest, Fort Wayne, Indiana, United States

Parkview Regional Cancer Center at Parkview Health, Fort Wayne, Indiana, United States

Center for Cancer Care at Goshen General Hospital, Goshen, Indiana, United States

Methodist Cancer Center at Methodist Hospital, Indianapolis, Indiana, United States

Central Indiana Cancer Centers - East, Indianapolis, Indiana, United States

St. Vincent Indianapolis Hospital, Indianapolis, Indiana, United States

Memorial Hospital of South Bend, South Bend, Indiana, United States

Genesis Regional Cancer Center at Genesis Medical Center, Davenport, Iowa, United States

John Stoddard Cancer Center at Iowa Methodist Medical Center, Des Moines, Iowa, United States

Holden Comprehensive Cancer Center at University of Iowa, Iowa City, Iowa, United States

CCOP - Kansas City, Prairie Village, Kansas, United States

Central Baptist Hospital, Lexington, Kentucky, United States

Lucille P. Markey Cancer Center at University of Kentucky, Lexington, Kentucky, United States

James Graham Brown Cancer Center at University of Louisville, Louisville, Kentucky, United States

Louisville Oncology at Norton Cancer Institute - Louisville, Louisville, Kentucky, United States

Mary Bird Perkins Cancer Center - Baton Rouge, Baton Rouge, Louisiana, United States

Ochsner Health Center - Bluebonnet, Baton Rouge, Louisiana, United States

CCOP - Ochsner, New Orleans, Louisiana, United States

CancerCare of Maine at Eastern Maine Medical Center, Bangor, Maine, United States

Central Maine Comprehensive Cancer Center at Central Maine Medical Center, Lewiston, Maine, United States

DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis, Maryland, United States

Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore, Maryland, United States

St. Agnes Hospital Cancer Center, Baltimore, Maryland, United States

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

Harry and Jeanette Weinberg Cancer Institute at Franklin Square Hospital Center, Baltimore, Maryland, United States

Central Maryland Oncology Center, Columbia, Maryland, United States

Shore Regional Cancer Center at Memorial Hospital - Easton, Easton, Maryland, United States

Union Hospital of Cecil County, Elkton, Maryland, United States

Peninsula Regional Medical Center, Salisbury, Maryland, United States

Holy Cross Hospital, Silver Spring, Maryland, United States

Massachusetts General Hospital, Boston, Massachusetts, United States

Boston University Cancer Research Center, Boston, Massachusetts, United States

Lahey Clinic Medical Center - Burlington, Burlington, Massachusetts, United States

NSMC Cancer Center - Peabody, Danvers, Massachusetts, United States

MetroWest Medical Center - Framingham Union Hospital, Framingham, Massachusetts, United States

Cape Cod Hospital, Hyannis, Massachusetts, United States

Saint Joseph Mercy Cancer Center, Ann Arbor, Michigan, United States

Battle Creek Health System Cancer Care Center, Battle Creek, Michigan, United States

Henry Ford Macomb Hospital, Clinton Township, Michigan, United States

Oakwood Cancer Center at Oakwood Hospital and Medical Center, Dearborn, Michigan, United States

Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, United States

Josephine Ford Cancer Center at Henry Ford Hospital, Detroit, Michigan, United States

Genesys Hurley Cancer Institute, Flint, Michigan, United States

McLaren Cancer Institute, Flint, Michigan, United States

Butterworth Hospital at Spectrum Health, Grand Rapids, Michigan, United States

CCOP - Grand Rapids, Grand Rapids, Michigan, United States

Van Elslander Cancer Center at St. John Hospital and Medical Center, Grosse Pointe Woods, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

Breslin Cancer Center at Ingham Regional Medical Center, Lansing, Michigan, United States

St. Joseph Mercy Oakland, Pontiac, Michigan, United States

William Beaumont Hospital - Royal Oak Campus, Royal Oak, Michigan, United States

Seton Cancer Institute at Saint Mary's - Saginaw, Saginaw, Michigan, United States

St. John Macomb Hospital, Warren, Michigan, United States

MeritCare Bemidji, Bemidji, Minnesota, United States

Fairview Ridges Hospital, Burnsville, Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States

St. Luke's Hospital Cancer Care Center, Duluth, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Mercy and Unity Cancer Center at Unity Hospital, Fridley, Minnesota, United States

Immanuel St. Joseph's, Mankato, Minnesota, United States

Minnesota Oncology - Maplewood, Maplewood, Minnesota, United States

Virginia Piper Cancer Institute at Abbott - Northwestern Hospital, Minneapolis, Minnesota, United States

Humphrey Cancer Center at North Memorial Outpatient Center, Robbinsdale, Minnesota, United States

Mayo Clinic Cancer Center, Rochester, Minnesota, United States

CentraCare Clinic - River Campus, Saint Cloud, Minnesota, United States

CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States

Park Nicollet Cancer Center, Saint Louis Park, Minnesota, United States

Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States

United Hospital, Saint Paul, Minnesota, United States

Ridgeview Medical Center, Waconia, Minnesota, United States

Minnesota Oncology - Woodbury, Woodbury, Minnesota, United States

University of Mississippi Cancer Clinic, Jackson, Mississippi, United States

Kansas City Cancer Centers - North, Kansas City, Missouri, United States

Billings Clinic - Downtown, Billings, Montana, United States

Great Falls Clinic - Main Facility, Great Falls, Montana, United States

Sletten Cancer Institute at Benefis Healthcare, Great Falls, Montana, United States

Montana Cancer Center at St. Patrick Hospital and Health Sciences Center, Missoula, Montana, United States

Good Samaritan Cancer Center at Good Samaritan Hospital, Kearney, Nebraska, United States

Methodist Estabrook Cancer Center, Omaha, Nebraska, United States

Immanuel Medical Center, Omaha, Nebraska, United States

Alegant Health Cancer Center at Bergan Mercy Medical Center, Omaha, Nebraska, United States

Creighton University Medical Center, Omaha, Nebraska, United States

CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Renown Institute for Cancer at Renown Regional Medical Center, Reno, Nevada, United States

Saint Mary's Regional Medical Center, Reno, Nevada, United States

Payson Center for Cancer Care at Concord Hospital, Concord, New Hampshire, United States

Seacoast Cancer Center at Wentworth - Douglass Hospital, Dover, New Hampshire, United States

Center for Cancer Care at Exeter Hospital, Exeter, New Hampshire, United States

Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, United States

Elliot Regional Cancer Center at Elliot Hospital, Manchester, New Hampshire, United States

Memorial Sloan-Kettering Cancer Center - Basking Ridge, Basking Ridge, New Jersey, United States

Trinitas Comprehensive Cancer Center at Trinitas Hospital, Elizabeth, New Jersey, United States

Dizzy Gillespie Cancer Institute at Englewood Hospital and Medical Center, Englewood, New Jersey, United States

St. Barnabas Medical Center Cancer Center, Livingston, New Jersey, United States

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, United States

Saint Peter's University Hospital, New Brunswick, New Jersey, United States

Newark Beth Israel Medical Center, Newark, New Jersey, United States

Frederick R. and Betty M. Smith Cancer Treatment Center, Sparta, New Jersey, United States

J. Phillip Citta Regional Cancer Center at Community Medical Center, Toms River, New Jersey, United States

St. Francis Regional Cancer Center, Trenton, New Jersey, United States

Cancer Institute of New Jersey at Cooper - Voorhees, Voorhees, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

New York Oncology Hematology, PC at Albany Regional Cancer Care, Albany, New York, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Sands Cancer Center, Canandaigua, New York, United States

Memorial Sloan-Kettering Cancer Center, Commack, New York, United States

Bassett Healthcare Regional Cancer Program at Mary Imogene Bassett Hospital, Cooperstown, New York, United States

CCOP - Hematology-Oncology Associates of Central New York, East Syracuse, New York, United States

Cayuga Medical Center of Ithaca, Ithaca, New York, United States

Queens Cancer Center of Queens Hospital, Jamaica, New York, United States

CCOP - North Shore University Hospital, Manhasset, New York, United States

Long Island Jewish Medical Center, New Hyde Park, New York, United States

Hudson Valley Oncology Associates, Poughkeepsie, New York, United States

Saint Francis Hospital Cancer Center, Poughkeepsie, New York, United States

Highland Hospital of Rochester, Rochester, New York, United States

Lipson Cancer and Blood Center at Rochester General Hospital, Rochester, New York, United States

University Radiation Oncology at Parkridge Hospital, Rochester, New York, United States

James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester, New York, United States

Memorial Sloan-Kettering Cancer Center at Phelps Memorial Hospital Center, Sleepy Hollow, New York, United States

SUNY Upstate Medical University Hospital, Syracuse, New York, United States

Mission Hospitals - Memorial Campus, Asheville, North Carolina, United States

Hope A Women's Cancer Center, Asheville, North Carolina, United States

Blumenthal Cancer Center at Carolinas Medical Center, Charlotte, North Carolina, United States

Presbyterian Cancer Center at Presbyterian Hospital, Charlotte, North Carolina, United States

Duke Cancer Institute, Durham, North Carolina, United States

Pardee Memorial Hospital, Hendersonville, North Carolina, United States

High Point Regional Hospital, High Point, North Carolina, United States

Cancer Centers of North Carolina - Raleigh, Raleigh, North Carolina, United States

Coastal Carolina Radiation Oncology Center, Wilmington, North Carolina, United States

Forsyth Regional Cancer Center at Forsyth Medical Center, Winston-Salem, North Carolina, United States

MeritCare Broadway, Fargo, North Dakota, United States

Altru Cancer Center at Altru Hospital, Grand Forks, North Dakota, United States

McDowell Cancer Center at Akron General Medical Center, Akron, Ohio, United States

Summa Center for Cancer Care at Akron City Hospital, Akron, Ohio, United States

Barberton Citizens Hospital, Barberton, Ohio, United States

Aultman Cancer Center at Aultman Hospital, Canton, Ohio, United States

Case Comprehensive Cancer Center, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center at Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, United States

Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

CCOP - Columbus, Columbus, Ohio, United States

Cleveland Clinic Cancer Center, Independence, Ohio, United States

St. Rita's Medical Center, Lima, Ohio, United States

Lima Memorial Hospital, Lima, Ohio, United States

MedCentral - Mansfield Hospital, Mansfield, Ohio, United States

Hillcrest Cancer Center at Hillcrest Hospital, Mayfield Heights, Ohio, United States

Community Hospital of Springfield and Clark County, Springfield, Ohio, United States

Flower Hospital Cancer Center, Sylvania, Ohio, United States

Medical University of Ohio Cancer Center, Toledo, Ohio, United States

St. Anne Mercy Hospital, Toledo, Ohio, United States

Cleveland Clinic - Wooster, Wooster, Ohio, United States

Natalie Warren Bryant Cancer Center at St. Francis Hospital, Tulsa, Oklahoma, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Willamette Valley Cancer Center - Eugene, Eugene, Oregon, United States

Three Rivers Community Hospital, Grants Pass, Oregon, United States

Legacy Mount Hood Medical Center, Gresham, Oregon, United States

Dubs Cancer Center at Rogue Valley Medical Center, Medford, Oregon, United States

Providence Cancer Center at PMCC, Medford, Oregon, United States

Providence Milwaukie Hospital, Milwaukie, Oregon, United States

Legacy Good Samaritan Hospital & Comprehensive Cancer Center, Portland, Oregon, United States

Providence Cancer Center at Providence Portland Medical Center, Portland, Oregon, United States

CCOP - Columbia River Oncology Program, Portland, Oregon, United States

Providence St. Vincent Medical Center, Portland, Oregon, United States

Legacy Emanuel Hospital and Health Center and Children's Hospital, Portland, Oregon, United States

Knight Cancer Institute at Oregon Health and Science University, Portland, Oregon, United States

Salem Hospital Regional Cancer Care Services, Salem, Oregon, United States

Legacy Meridian Park Hospital, Tualatin, Oregon, United States

UPMC Cancer Center at Beaver Medical Center, Beaver, Pennsylvania, United States

St. Luke's Cancer Network at St. Luke's Hospital, Bethlehem, Pennsylvania, United States

Geisinger Cancer Institute at Geisinger Health, Danville, Pennsylvania, United States

Delaware County Regional Cancer Center at Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States

Northeast Radiation Oncology Center, Dunmore, Pennsylvania, United States

Regional Cancer Center - Erie, Erie, Pennsylvania, United States

PinnacleHealth Regional Cancer Center at Polyclinic Hospital, Harrisburg, Pennsylvania, United States

Intercommunity Cancer Center, Monroeville, Pennsylvania, United States

Norristown Regional Cancer Center, Norristown, Pennsylvania, United States

Drexel University College of Medicine - Center City Hahnemann Campus, Philadelphia, Pennsylvania, United States

Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center - Philadelphia, Philadelphia, Pennsylvania, United States

Frankford Hospital Cancer Center - Torresdale Campus, Philadelphia, Pennsylvania, United States

Allegheny Cancer Center at Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

UPMC - Shadyside, Pittsburgh, Pennsylvania, United States

Western Pennsylvania Cancer Institute at Western Pennsylvania Hospital, Pittsburgh, Pennsylvania, United States

McGlinn Family Regional Cancer Center at Reading Hospital and Medical Center, Reading, Pennsylvania, United States

Mount Nittany Medical Center, State College, Pennsylvania, United States

Crozer-Chester Medical Center, Upland, Pennsylvania, United States

Frank M. and Dorothea Henry Cancer Center at Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States

York Cancer Center at Apple Hill Medical Center, York, Pennsylvania, United States

Rhode Island Hospital Comprehensive Cancer Center, Providence, Rhode Island, United States

Northmain Radiation Oncology, Providence, Rhode Island, United States

Roper St. Francis Cancer Center at Roper Hospital, Charleston, South Carolina, United States

Hollings Cancer Center at Medical University of South Carolina, Charleston, South Carolina, United States

Georgetown Memorial Hospital, Georgetown, South Carolina, United States

Rapid City Regional Hospital, Rapid City, South Dakota, United States

Sanford Cancer Center at Sanford USD Medical Center, Sioux Falls, South Dakota, United States

Thompson Cancer Survival Center, Knoxville, Tennessee, United States

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States

Texas Oncology, PA at Harris Center HEB, Bedford, Texas, United States

Simmons Comprehensive Cancer Center at University of Texas Southwestern Medical Center - Dallas, Dallas, Texas, United States

Texas Oncology, PA at Texas Cancer Center - Denton South, Denton, Texas, United States

Klabzuba Cancer Center at Harris Methodist Fort Worth Hospital, Fort Worth, Texas, United States

M. D. Anderson Cancer Center at University of Texas, Houston, Texas, United States

Baylor Medical Center at Irving, Irving, Texas, United States

Texas Oncology, PA at Lake Vista Cancer Center, Lewisville, Texas, United States

Joe Arrington Cancer Research and Treatment Center, Lubbock, Texas, United States

Texas Oncology, PA at Texas Cancer Center Round Rock, Round Rock, Texas, United States

Cancer Care Centers of South Texas - Northeast, San Antonio, Texas, United States

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Texas Oncology, PA at Texas Cancer Center - Sherman, Sherman, Texas, United States

Texas Oncology, PA at Texas Oncology Cancer Center Sugar Land, Sugar Land, Texas, United States

Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States

Val and Ann Browning Cancer Center at McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center - Provo, Provo, Utah, United States

Dixie Regional Medical Center - East Campus, Saint George, Utah, United States

Utah Cancer Specialists at UCS Cancer Center, Salt Lake City, Utah, United States

Huntsman Cancer Institute at University of Utah, Salt Lake City, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

Fletcher Allen Health Care - University Health Center Campus, Burlington, Vermont, United States

University of Virginia Cancer Center, Charlottesville, Virginia, United States

Naval Medical Center - Portsmouth, Portsmouth, Virginia, United States

Virginia Commonwealth University Massey Cancer Center, Richmond, Virginia, United States

St. Joseph Cancer Center, Bellingham, Washington, United States

Seattle Cancer Care Alliance, Seattle, Washington, United States

University Cancer Center at University of Washington Medical Center, Seattle, Washington, United States

Providence Cancer Center at Sacred Heart Medical Center, Spokane, Washington, United States

Southwest Washington Medical Center Cancer Center, Vancouver, Washington, United States

West Virginia University Health Sciences Center - Charleston, Charleston, West Virginia, United States

St. Mary's Regional Cancer Center at St. Mary's Medical Center, Huntington, West Virginia, United States

Schiffler Cancer Center at Wheeling Hospital, Wheeling, West Virginia, United States

Center for Cancer Treatment & Prevention at Sacred Heart Hospital, Eau Claire, Wisconsin, United States

St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States

Vince Lombardi Cancer Clinic - Green Bay at Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

Franciscan Skemp Healthcare - La Crosse Campus, La Crosse, Wisconsin, United States

Dean Medical Center - Madison, Madison, Wisconsin, United States

University of Wisconsin Paul P. Carbone Comprehensive Cancer Center, Madison, Wisconsin, United States

Marshfield Clinic - Marshfield Center, Marshfield, Wisconsin, United States

Community Memorial Hospital Cancer Care Center, Menomonee Falls, Wisconsin, United States

Columbia Saint Mary's Hospital - Ozaukee, Mequon, Wisconsin, United States

Columbia-Saint Mary's Cancer Care Center, Milwaukee, Wisconsin, United States

Vince Lombardi Cancer Clinic at Aurora St. Luke's Medical Center, Milwaukee, Wisconsin, United States

Medical College of Wisconsin Cancer Center, Milwaukee, Wisconsin, United States

Regional Cancer Center at Oconomowoc Memorial Hospital, Oconomowoc, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine, Wisconsin, United States

Saint Michael's Hospital Cancer Center, Stevens Point, Wisconsin, United States

Aurora Medical Center, Summit, Wisconsin, United States

Waukesha Memorial Hospital Regional Cancer Center, Waukesha, Wisconsin, United States

University of Wisconcin Cancer Center at Aspirus Wausau Hospital, Wausau, Wisconsin, United States

West Allis Memorial Hospital, West Allis, Wisconsin, United States

Diagnostic and Treatment Center, Weston, Wisconsin, United States

Cross Cancer Institute at University of Alberta, Edmonton, Alberta, Canada

British Columbia Cancer Agency - Vancouver Island Centre, Victoria, British Columbia, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

London Regional Cancer Program at London Health Sciences Centre, London, Ontario, Canada

Odette Cancer Centre at Sunnybrook, Toronto, Ontario, Canada

Hopital Notre-Dame du CHUM, Montreal, Quebec, Canada

Royal Victoria Hospital - Montreal, Montreal, Quebec, Canada

Montreal General Hospital, Montreal, Quebec, Canada

Jewish General Hospital - Montreal, Montreal, Quebec, Canada

Hopital du Saint-Sacrement - Quebec, Quebec City, Quebec, Canada

Saskatoon Cancer Centre at the University of Saskatchewan, Saskatoon, Saskatchewan, Canada

University College Hospital, Galway, , Ireland

Tel-Aviv Sourasky Medical Center, Tel Aviv, , Israel

Contact Details

Name: Norman Wolmark, MD

Affiliation: NSABP Foundation Inc

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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