⭐️⭐️⭐️⭐️⭐️ "A total no brainer"

⭐️⭐️⭐️⭐️⭐️ "Love this, so easy."

Spots is the easy way to track your skin, mole and cancer changes.

Spots Global Cancer Trial Database for Ribociclib-endocrine Combination Therapy Versus Chemotherapy as 1st Line in Visceral mBC

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Ribociclib-endocrine Combination Therapy Versus Chemotherapy as 1st Line in Visceral mBC

Official Title: Ribociclib-endocrine Combination Therapy Versus Chemotherapy as 1st Line Treatment in Patients With Visceral Metastatic Breast Cancer. A Multicenter, Randomized Phase III Trial.

Study ID: NCT03905343

Conditions

Breast Cancer

Study Description

Brief Summary: The aim of this trial is to assess if patients treated with the combination of ribociclib and endocrine therapy respond to treatment as fast as patients treated with chemotherapy only, without decreasing their quality of life (QoL).

Detailed Description: Breast cancer is the most frequent malignancy in women and the leading cause of cancer mortality in most countries in Europe. Metastatic breast cancer remains an incurable disease with a median overall survival (OS) of 2-4 years and a 5-year survival of only 25%. Patients with hormone receptor (HR)-positive breast cancer involving visceral disease at diagnosis have an even worse outcome. Many oncologists still prefer to treat visceral disease primarily with chemotherapy rather than with endocrine treatment, thinking to receive a faster response with chemotherapy than with endocrine therapy, especially in patients with clinical symptoms or potentially threatening lesions. However, results from cross-sectional clinical practice studies suggest that endocrine therapy is associated with better quality of life, fewer concerns about side effects, less activity impairment and higher treatment satisfaction compared to chemotherapy. In addition, with the new data of CDK4/6 inhibitors combined with endocrine treatment there is an even better efficacy data available compared to endocrine therapy alone. The aim of this trial is to assess if patients treated with the combination of ribociclib and endocrine therapy respond to treatment as fast as patients treated with chemotherapy only, without decreasing their quality of life (QoL).

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Med. Univ. Klinik Graz, Graz, , Austria

Tirol Kliniken - BrustGesundheitZentrum Tirol, Innsbruck, , Austria

Salzburger Landeskliniken - Universitätsklinikum Salzburg, Salzburg, , Austria

Universitätsklinik für Frauenheilkunde, Wien, , Austria

Algemeen Ziekenhuis Klina, Brasschaat, , Belgium

Grand Hôpital de Charleroi, Charleroi, , Belgium

Jessa Ziekenhuis, Hasselt, , Belgium

CHC Mont Légia, Liège, , Belgium

CHU de Liege, Liège, , Belgium

CHR de la Citadelle, Liége, , Belgium

CHU UCL Namur - Site Sainte Elisabeth, Namur, , Belgium

Clinique-Saint-Pierre, Ottignies, , Belgium

Kantonsspital Baden, Baden, , Switzerland

Kantonsspital Baden, Baden, , Switzerland

Universitaetsspital-Basel, Basel, , Switzerland

Brustzentrum Basel - Praxis für ambulante Tumortherapie, Basel, , Switzerland

Istituto Oncologico della Svizzera Italiana - Ospedale Regionale Bellinzona e Valli, Bellinzona, , Switzerland

Inselspital Bern, Bern, , Switzerland

Kantonsspital Graubuenden, Chur, , Switzerland

Clinique des Grangettes, Chêne-Bougeries, , Switzerland

Hôpital neuchâtelois, La Chaux-de-Fonds, , Switzerland

Centre Hospitalier Universitaire Vaudois, Lausanne, , Switzerland

Kantonsspital Liestal, Liestal, , Switzerland

Kantonsspital Luzern, Luzern, , Switzerland

Hirslanden Klinik St. Anna Luzern, Luzern, , Switzerland

Onkologie Zentrum Spital Männedorf, Männedorf, , Switzerland

Kantonsspital Olten, Olten, , Switzerland

Hôpital de Sion, Sion, , Switzerland

Brustzentrum Ostschweiz, St. Gallen, , Switzerland

Kantonsspital - St. Gallen, St. Gallen, , Switzerland

Spital STS AG, Thun, , Switzerland

Kantonsspital Winterthur, Brustzentrum, Winterthur, , Switzerland

Onkologie Bellevue, Zurich, , Switzerland

OnkoZentrum Zürich AG - Klinik im Park, Zürich, , Switzerland

Universitäts Spital Zürich, Zürich, , Switzerland

Contact Details

Name: Thomas Ruhstaller, Prof

Affiliation: Kantonsspital St. Gallen - Breast Center St. Gallen

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

Logo

Take Control of Your Skin and Body Changes Today.

Try out Spots for free, set up only takes 2 mins.

spots app storespots app store

Join others from around the world: