Spots Global Cancer Trial Database for Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
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Trial Identification
Brief Title: Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
Official Title: Quantitative Subharmonic Breast Imaging: Subharmonic Imaging and Pressure Estimation for Monitoring Neoadjuvant Chemotherapy
Study ID: NCT02115607
Conditions
Interventions
Study Description
Brief Summary: This is a diagnostic accuracy study to evaluate if two novel ultrasound (US) techniques, quantitative 3D subharmonic imaging (SHI) and Subharmonic Aided Pressure Estimation (SHAPE), used with an intravenous ultrasound contrast agent (Definity, Lantheus Medical Imaging, Billerica, MA), can track changes in locally advanced breast cancer (LABC) angiogenesis and interstitial fluid pressure (IFP), respectively, by studying women undergoing neoadjuvant chemotherapy before as well as with around 10% and 60% (in part 1) or 30% (in part 2) of the neoadjuvant chemotherapy treatment delivered and after completion of the neoadjuvant chemotherapy treatment. Results will be compared to MRI and pathology.
Detailed Description:
Eligibility
Minimum Age: 21 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
Thomas Jefferson University, Philadelphia, Pennsylvania, United States
Contact Details
Name: Flemming Forsberg, PhD
Affiliation: Thomas Jefferson University
Role: PRINCIPAL_INVESTIGATOR
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