Spots Global Cancer Trial Database for Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer
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Trial Identification
Brief Title: Comparing Letrozole Given Alone to Letrozole Given With Avastin in Post-Menopausal Women Breast Cancer
Official Title: A Phase II, Randomized, Open Label Trial of Pre-operative (Neoadjuvant)Letrozole (Femara) vs. Letrozole in Combination With Avastin in Post Menopausal Women With Newly Diagnosed Operable Breast Cancer
Study ID: NCT00530868
Study Description
Brief Summary: This purpose of this trial is to show that the combination of Avastin and hormone therapy should be more effective than hormone therapy alone for the treatment of breast cancer.
Detailed Description: Preclinical and clinical data have demonstrated that up-regulation of tumor cell VEGF is an important mechanism to subvert estrogen dependence in hormone responsive breast cancer resulting in reduced therapy response or tumor resistance to hormonal therapy; thus, it is hypothesized that the combination of an anti-VEGF agent (Avastin, an anti-VEGF monoclonal antibody) and hormonal therapy should be more effective than hormonal therapy alone for the treatment of breast cancer.
Eligibility
Minimum Age: 19 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Alabama at Birmingham, Birmingham, Alabama, United States
University of California, San Francisco Comprehensive Cancer Center, San Francisco, California, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
Georgia Cancer Specialists, Atlanta, Georgia, United States
University of Chicago Medical Center, Chicago, Illinois, United States
Dana Farber Cancer Institute, Boston, Massachusetts, United States
University of of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
Contact Details
Name: Lisle Nabell, M.D.
Affiliation: University of Alabama at Birmingham
Role: PRINCIPAL_INVESTIGATOR
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