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Brief Title: A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
Official Title: A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer
Study ID: NCT00887536
Brief Summary: The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from returning. A second purpose of this study is to learn if adding bevacizumab to treatment with chemotherapy will help women with HER2-negative breast cancer live longer. The researchers also want to learn about the side effects of the combination of drugs used in this study.
Detailed Description: The B-46-I/07132 study, a multicenter, open-label, randomized Phase III, adjuvant therapy trial, will compare the value of adding bevacizumab to a non-anthracycline-based chemotherapy regimen relative to the same chemotherapy without bevacizumab and relative to an anthracycline-based chemotherapy regimen in women with resected node-positive or high-risk node-negative, HER2-negative breast cancer. This trial will determine whether the addition of bevacizumab to a regimen of docetaxel and cyclophosphamide (TCB) improves invasive disease-free survival relative to docetaxel and cyclophosphamide alone (TC). A secondary aim will be to determine whether the addition of bevacizumab to TC improves invasive disease-free survival compared to a regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC). Other secondary aims include whether TCB improves disease-free survival, overall survival, and recurrence-free interval relative to TC alone and to TAC. The toxicities of the three regimens will also be compared. Patients in the B-46-I/07132 study will be randomized to one of three treatment regimens: Group 1 patients will receive 6 cycles of TAC administered every 21 days (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2); Group 2 patients will receive 6 cycles of TC administered every 21 days (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2); and Group 3 patients will receive 6 cycles of TCB every 21 days with bevacizumab therapy continuing every 21 days after completion of chemotherapy until 1 year following the first dose (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2, and bevacizumab 15 mg/kg). Primary prophylaxis with pegfilgrastim or filgrastim is required for Group 1 patients (optional for patients in Groups 2 and 3). Patients will also receive adjuvant radiation therapy as clinically indicated and endocrine therapy for hormone receptor-positive tumors. Tumor samples will be submitted for correlative science studies to evaluate predictors of study therapy benefit. Submission of a tumor sample is a study requirement for all patients.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Birmingham Hematology and Oncology, Bessemer, Alabama, United States
Birmingham Hematology and Oncology, Birmingham, Alabama, United States
Birmingham Hematology and Oncology - Brookwood, Birmingham, Alabama, United States
Birmingham Hematology and Oncology - Princeton, Birmingham, Alabama, United States
Birmingham Hematology and Oncology - Montclair, Birmingham, Alabama, United States
Birmingham Hematology and Oncology - Pilot, Birmingham, Alabama, United States
Clearview Cancer Institute- Huntsville, Huntsville, Alabama, United States
Northern Arizona Hematology & Onclogy Associates, Flagstaff, Arizona, United States
Arizona Oncolocy (CASA-Green Valley), Green Valley, Arizona, United States
Arizona Oncology (CASA- Oro Valley), Oro Valley, Arizona, United States
Hematology Oncology Associates, Phoenix, Arizona, United States
Northern Arizona Hematology & Oncology Associates, Prescott Valley, Arizona, United States
Arizona Oncology (CASA-Safford), Safford, Arizona, United States
Hematology Oncology Associates, Scottsdale, Arizona, United States
Northern Arizona Hematology & Oncology Associates, Sedona, Arizona, United States
Arizona Oncology Associates - Rudasill, Tucson, Arizona, United States
Arizona Oncology Associates - Carondelet, Tucson, Arizona, United States
Arizona Oncology (CASA-Craycroft), Tucson, Arizona, United States
Arizona Oncology (CASA-Office Only), Tucson, Arizona, United States
Arizona Oncology - CASA St. Mary's, Tucson, Arizona, United States
Central Hematology/Oncology Medical Group, Inc., Alhambra, California, United States
Kaiser Permanente Deer Valley Med Center, Antioch, California, United States
Comp Blook and Cancer Center, Bakersfield, California, United States
Southwest Cancer Care (E. Grand), Escondido, California, United States
Kaiser Permanente Fremont, Fremont, California, United States
St. Jude Heritage Healthcare, Fullerton, California, United States
Kaiser Permanente Medical Center - Hayward, Hayward, California, United States
Pacific Shores Medical Group, Huntington Beach, California, United States
Southern California Permanente Medical Group, Irvine, California, United States
Wilshire Oncology Medical Group (Business Office), La Verne, California, United States
Antelope Valley Cancer Center, Lancaster, California, United States
Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center, Long Beach, California, United States
Todd Cancer Institute at Long Beach Memorial Med Cent, Long Beach, California, United States
Pacific Shores Medical Group, Long Beach, California, United States
Pacific Shores Medical Group, Los Alamitos, California, United States
TORI- N Valley Hematology Oncology Med Group, Mission Hills, California, United States
TORI - Oncology Care Medical Assoc., Montebello, California, United States
Southwest Cancer Care (Medical Center), Murrieta, California, United States
NValley Hematology/Oncology Medical Group, Northridge, California, United States
Kaiser Permanente-Oakland, Oakland, California, United States
St. Joseph Hospital, Orange, California, United States
Ventura County Hematology-Oncology Specialists, Oxnard, California, United States
Stanford University Medical Center, Palo Alto, California, United States
Kaiser Permanente Medical Center - Redwood City, Redwood City, California, United States
Kaiser Permanente Medical Center - Richmond, Richmond, California, United States
Sutter Roseville Medical Center, Roseville, California, United States
Kaiser Permanente Roseville, Roseville, California, United States
Sutter Medical Center, Sacramento, California, United States
Kaiser Permanente, South Sacramento, Sacramento, California, United States
Kaiser Permanente Medical Center - Sacramento, Sacramento, California, United States
Kaiser Permanente-San Diego, San Diego, California, United States
Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco, California, United States
TORI - Oncology Care Med Assoc, San Gabriel, California, United States
Kaiser Permanente Santa Teresa, San Jose, California, United States
Kaiser Permanente San Rafael, San Rafael, California, United States
Santa Barbara Hematology Oncology Medical Group, Santa Barbara, California, United States
Santa Barbara II (Samsum Clinic) - TORI, Santa Barbara, California, United States
Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara, California, United States
Central Coast Medical Oncology Corporation, Santa Maria, California, United States
Kaiser Permanente Medical Center - Santa Rosa, Santa Rosa, California, United States
Santa Barbara Hematology/Oncology Medical Group, Inc, Solvang, California, United States
Kaiser Permanente-South San Francisco, South San Francisco, California, United States
Kaiser Permanente Medical Facility - Stockton, Stockton, California, United States
Olive View/UCLA Medical Center, Sylmar, California, United States
Kaiser Permanente Medical Center Vacaville, Vacaville, California, United States
Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States
Kaiser Permanente Medical Center - Walnut Creek, Walnut Creek, California, United States
Trivalley Oncology Hematology, Westlake Village, California, United States
Westlake Infusion Center, Westlake Village, California, United States
TORI - Oncology Care Med Assoc, Whittier, California, United States
Medical Center of Aurora, Aurora, Colorado, United States
Rocky Mountain Cancer Center, Aurora, Colorado, United States
Rocky Mountain Cancer Centers - Boulder, Boulder, Colorado, United States
Penrose/St. Francis Healthcare System, Colorado Springs, Colorado, United States
Rocky Mountain Cancer Center at the Pivillion- Fontanero, Colorado Springs, Colorado, United States
Rocky Mountain Cancer Center - CO Springs, Colorado Springs, Colorado, United States
Kaiser Permanente-Franklin, Denver, Colorado, United States
CCOP - Colorado Cancer Research Program, Inc., Denver, Colorado, United States
Porter Adventist Hospital, Denver, Colorado, United States
Exempla St. Joseph Hospital, Denver, Colorado, United States
Rocky Mountain Cancer Center - Midtown, Denver, Colorado, United States
Rocky Mountain Cancer Center - 9th Avenue, Denver, Colorado, United States
Rocky Mountain Cancer Center - Rose, Denver, Colorado, United States
University of Colorado, Denver, Colorado, United States
Shaw Regional Cancer Center, Edwards, Colorado, United States
Swedish Medical Center, Englewood, Colorado, United States
Front Range Cancer Specialists, Fort Collins, Colorado, United States
Poudre Valley Hospital, Fort Collins, Colorado, United States
St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States
St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States
North Colorado Medical Center, Greeley, Colorado, United States
Kaiser Permanente Rock Creek, Lafayette, Colorado, United States
Rocky Mountain Cancer Center, Lakewood, Colorado, United States
Rocky Mountain Cancer Center - Dry Creek, Littleton, Colorado, United States
Rocky Mountain Cancer Center- Sky Ridge, Lone Tree, Colorado, United States
Rocky Mountain Cancer Center - Longmont, Longmont, Colorado, United States
McKee Medical Center, Loveland, Colorado, United States
Rocky Mountain Cancer Center, Parker, Colorado, United States
Rocky Mountain Cancer Centers, Thornton, Colorado, United States
Exempla Lutheran Medical Center, Wheat Ridge, Colorado, United States
University of Connecticut, Farmington, Connecticut, United States
Hartford Hospital, Hartford, Connecticut, United States
Washington Regional Cancer Center, Washington, District of Columbia, United States
Sibley Memorial Hospital, Washington, District of Columbia, United States
SCRI - Florida Cancer Specialists- Bonita Springs, Bonita Springs, Florida, United States
SCRI - Florida Cancer Specialists - Bradenton, Bradenton, Florida, United States
Florida Cancer Specialists, Brandon, Florida, United States
SCRI Florida Cancer Specialists - Cape Coral (1708), Cape Coral, Florida, United States
SCRI Florida Cancer Specialists - Cape Coral (811), Cape Coral, Florida, United States
Morton Plant Mease Health Care, Clearwater, Florida, United States
SCRI Florida Cancer Specialists - Englewood, Englewood, Florida, United States
Holy Cross Hospital, Fort Lauderdale, Florida, United States
SCRI Florida Cancer Specialists - Fort Myers (Hampshire), Fort Myers, Florida, United States
SCRI Florida Cancer Specialists - Ft. Myers (Broadway), Fort Myers, Florida, United States
SCRI Florida Cancer Specialists- Fort Myers (Veronica), Fort Myers, Florida, United States
University of Florida Shands Cancer Center, Gainesville, Florida, United States
Florida Cancer Institute - New Hope, Hudson, Florida, United States
TORI-ICON - Shircl, Jacksonville, Florida, United States
Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States
Integrated Community Oncology Network (ICON), Jacksonville, Florida, United States
TORI-ICON St.Aug, Jacksonville, Florida, United States
CCOP, Jupiter Medical Cener, Jupiter, Florida, United States
Ocala Oncology Center - Lady Lake, Lady Lake, Florida, United States
Melbourne International Medicine Associates, Melbourne, Florida, United States
CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States
Advanced Medical Specialties - AMS, Miami, Florida, United States
Advanced Medical Specialists- Sunset, Miami, Florida, United States
Advanced Medical Specialties - N Kendall (STE 300E), Miami, Florida, United States
Advanced Medical Specialties - N. Kendall (STE 905E), Miami, Florida, United States
SCRI Florida Cancer Specialists - Naples (Goodlette), Naples, Florida, United States
SCRI Florida Cancer Specialists - Naples (Pine), Naples, Florida, United States
Florida Cancer Institute - New Hope, New Port Richey, Florida, United States
Ocala Oncology Center, Ocala, Florida, United States
Cancer Centers of Florida, P.A., Ocoee, Florida, United States
Tori-Icon, Orange Park, Florida, United States
Florida Hospital, Orlando, Florida, United States
Cancer Centers of Florida, P.A., Orlando, Florida, United States
MD Anderson Cancer Center, Orlando, Florida, United States
SCRI - Florida Cancer Specialists - Port Charlotte, Port Charlotte, Florida, United States
Tori-Icon, Saint Augustine, Florida, United States
SCRI Florida Cancer Specialists - Sarasota (Cattleman), Sarasota, Florida, United States
SCRI- Florida Cancer Specialists - Sarasota, Sarasota, Florida, United States
SCRI - Florida Cancer Specialists - Armenia, Tampa, Florida, United States
SCRI - Florida Cancer Specialists - Tampa, Tampa, Florida, United States
SCRI Florida Cancer Specialists - Venice (Tamiami), Venice, Florida, United States
SCRI Florida Cancer Specilaists - Venice, Venice, Florida, United States
Cancer Centers of Florida, P.A., Winter Park, Florida, United States
Phoebe Putney Memorial Hospital, Albany, Georgia, United States
Northwest Georgia Oncology Centers, Austell, Georgia, United States
Northwest Georgia Oncology Centers, Carrollton, Georgia, United States
Dublin Hematology/Oncology, Dublin, Georgia, United States
Suburban Hematology-Oncology Associates, Lawrenceville, Georgia, United States
Northwest Georgia Oncology Centers, Marietta, Georgia, United States
SCRI Chattanooga Oncol & Hematol Assoc, PC - Ringgold, Ringgold, Georgia, United States
Memorial Health University Medical Center, Savannah, Georgia, United States
University of Hawaii, Honolulu, Hawaii, United States
Kaiser Permanente Hawaii - Moanalua Med Center, Honolulu, Hawaii, United States
Cancer Care & Hematology Specialists of Chicagoland, Arlington, Illinois, United States
Rush University Medical Center, Chicago, Illinois, United States
Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States
CCOP NorthShore University HealthSystem, Evanston, Illinois, United States
Ingalls Memorial Hospital, Harvey, Illinois, United States
Hinsdale Hematology Oncology Associates, Hinsdale, Illinois, United States
Edward Hospital, Naperville, Illinois, United States
Cancer Care & Hematology Specialists of Chicagoland, Niles, Illinois, United States
Advocate Lutheran General Cancer Care Center, Park Ridge, Illinois, United States
Carle Cancer Center, CCOP, Urbana, Illinois, United States
Carle Foundation Hospital, Urbana, Illinois, United States
Cancer Care and Hematology Specialists of Chicagoland, Winfield, Illinois, United States
Central Indiana Cancer Centers, Carmel, Indiana, United States
Central Indiana Cancer Centers, Fishers, Indiana, United States
Central Indiana Cancer Centers, Greenfield, Indiana, United States
Central Indiana Cancer Centers, Indianapolis, Indiana, United States
Central Indiana Cancer Centers (E. County), Indianapolis, Indiana, United States
St. Vincent Hospital and Health Care Center, Indianapolis, Indiana, United States
Clarian Arnett Cancer Care, Lafayette, Indiana, United States
Community Hospital, Munster, Indiana, United States
Genesis Medical Center, Davenport, Iowa, United States
Finley Hospital, Dubuque, Iowa, United States
University of Iowa, Iowa City, Iowa, United States
Mercy Medical Center - Sioux City, Sioux City, Iowa, United States
Siouxland Hematology-Oncology Associates, Sioux City, Iowa, United States
St. Luke's Regional Medical Center, Sioux City, Iowa, United States
Covenant Cancer Treatment Center, Waterloo, Iowa, United States
Kansas Cty Cancer Center - West, Kansas City, Kansas, United States
Menorah Medical Center, Overland Park, Kansas, United States
Kansas City Cancer Center (CBO), Overland Park, Kansas, United States
Kansas CityCancer Centers - Southwest, Overland Park, Kansas, United States
Kansas City Cancer Center, Shawnee Mission, Shawnee Mission, Kansas, United States
SCRI Oncology Hematology Care, Inc. Crestview Hills (CVH), Crestview Hills, Kentucky, United States
University of Kentucky Medical Center, Lexington, Kentucky, United States
NortonHealtcare Inc., Louisville, Kentucky, United States
Consultants in Blood Disorders and Cancer, Louisville, Kentucky, United States
Christus St. Frances Cabrini Hospital, Alexandria, Louisiana, United States
Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States
Tulane University Medical Center, New Orleans, Louisiana, United States
Eastern Maine Medical Center, Bangor, Maine, United States
Mercy Medical Center, Baltimore, Maryland, United States
St. Joseph's Medical Center, Baltimore, Maryland, United States
Greater Baltimore Medical Center, Baltimore, Maryland, United States
Franklin Square Hospital Center, Baltimore, Maryland, United States
SCRI - Center for Cancer and Blood Disorders, Bethesda, Maryland, United States
Suburban Hospital, Bethesda, Maryland, United States
Chevy Chase Healthcare Management, LLC, Chevy Chase, Maryland, United States
Maryland Oncology Hematology PA, Columbia, Maryland, United States
Frederick Memorial Hospital, Frederick, Maryland, United States
Alliance Hematology Oncology PA, Owings Mills, Maryland, United States
Penisula Regional Medical Center, Salisbury, Maryland, United States
Holy Cross Hospital, Silver Spring, Maryland, United States
Alliance Hematology Oncology PA, Westminster, Maryland, United States
Saint Anne's Hospital, Fall River, Massachusetts, United States
Berkshire Hematology Oncology, P.C., Pittsfield, Massachusetts, United States
CCOP, St. Joseph Mercy Hospital, Ann Arbor, Michigan, United States
Bay Regional Medical Center, Bay City, Michigan, United States
CCOP - Oakwood Hospital and Medical Center, Dearborn, Michigan, United States
Henry Ford Health System, Detroit, Michigan, United States
CCOP - St. John Hospital and Medical Center, Detroit, Michigan, United States
Michigan State University, East Lansing, Michigan, United States
CCOP - Genesys Regional Hospital, Flint, Michigan, United States
CCOP - Hurley Medical Center, Flint, Michigan, United States
McLaren Regional Medical Center, Flint, Michigan, United States
CCOP - Allegiance Health, Jackson, Michigan, United States
Borgess Medical Center, Kalamazoo, Michigan, United States
Bronson Methodist Hospital, Kalamazoo, Michigan, United States
West Michigan Cancer Center, Kalamazoo, Michigan, United States
Ingham Regional Medical Center - Lansing, Lansing, Michigan, United States
CCOP, Sparrow Health System, Lansing, Michigan, United States
Lapeer Regional Hospital, Lapeer, Michigan, United States
CCOP - St. Mary Mercy Hospital - Livonia, Livonia, Michigan, United States
Marquette General Hospital, Marquette, Michigan, United States
Mount Clemens Regional Medical Center, Mount Clemens, Michigan, United States
Memorial Healthcare, Owosso, Michigan, United States
CCOP - St. Joseph Mercy Hospital - Oakland, Pontiac, Michigan, United States
CCOP - St. Joseph Mercy Port Huron, Port Huron, Michigan, United States
CCOP, William Beaumont Hospital, Royal Oak, Michigan, United States
CCOP, St. Mary's Medical Center, Saginaw, Michigan, United States
Providence Hospital - Southfield, Southfield, Michigan, United States
CCOP, St. John Macomb Hospital, Warren, Michigan, United States
Minnesota Oncology Hematology-Burnsville, Burnsville, Minnesota, United States
Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States
St. Luke's Hospital, Duluth, Minnesota, United States
Fairview Southdale Hospital, Edina, Minnesota, United States
Minnesota Oncology Hematology-Edina, Edina, Minnesota, United States
Unity Hospital, Fridley, Minnesota, United States
Minnesota Oncology Hematology PA - Maplewood, Maplewood, Minnesota, United States
St. John's Hospital Northeast/HealthEast, Inc., Maplewood, Minnesota, United States
Minnesota Oncology Hematology-Minneapolis, Minneapolis, Minnesota, United States
Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States
Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States
North Memorial Health Care, Robbinsdale, Minnesota, United States
CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States
Park Nicollet Health Services, Saint Louis Park, Minnesota, United States
Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States
Minnesota Hematology Oncology-St. Paul, Saint Paul, Minnesota, United States
Minnesota Oncology Hematology, Woodbury, Minnesota, United States
Missouri Cancer Associates, Columbia, Missouri, United States
University of Missouri-Ellis Fischel, Columbia, Missouri, United States
Kansas City Cancer Center - Central, Kansas City, Missouri, United States
Saint Luke's Hospital, Kansas City, Missouri, United States
CCOP - Kansas City, Kansas City, Missouri, United States
Kansas City Cancer Center - South, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Research Medical Center, Kansas City, Missouri, United States
Kansas City Cancer Center - North, Kansas City, Missouri, United States
Kansas City Cancer Centers - East, Lee's Summit, Missouri, United States
St. Louis University Health Sciences Center, Saint Louis, Missouri, United States
Nebraska Cancer Research Center, Lincoln, Nebraska, United States
St. Elizabeth Community Health Center, Lincoln, Nebraska, United States
Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States
Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States
CCOP, Missouri Valley Cance Consortium, Omaha, Nebraska, United States
Creighton University Cancer Center, Omaha, Nebraska, United States
Alegent Health Midlands Hospital, Papillion, Nebraska, United States
Comprehensive Cancer Centers of Nevada (Siena), Henderson, Nevada, United States
US Oncology West Region Office (Horizon Ridge), Henderson, Nevada, United States
Comprehensive Cancer Centers of Nevada (Wigwam), Henderson, Nevada, United States
Comprehensive Cancer Centers of Nevada (Peak Dr.), Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada (Southern Hills), Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada (Twain), Las Vegas, Nevada, United States
Renown Regional Medical Center, Reno, Nevada, United States
Cancer Institute of New Jersey at Hamilton, Hamilton, New Jersey, United States
Hematology-Oncology Associates of NNJ, PA, Morristown, New Jersey, United States
Cancer Institute of New Jersey, New Brunswick, New Jersey, United States
Newark Beth Israel Medical Center, Newark, New Jersey, United States
Saint Clare's Center at Parsippany Commons, Parsippany, New Jersey, United States
Somerset Medical Center, Somerville, New Jersey, United States
Sparta Cancer Center, Sparta, New Jersey, United States
Texas Oncology PA Las Cruces, Las Cruces, New Mexico, United States
New Mexico Cancer Care Associates, Santa Fe, New Mexico, United States
New York Oncology Hematology PC-Albany, Albany, New York, United States
New York Oncology Hematology, PC at Albany Medical Center, Albany, New York, United States
Amsterdam Community Cancer Program, Amsterdam, New York, United States
Interlakes Oncology Hematology PC, Brockport, New York, United States
Interlakes Oncology & Hematology, P.C., Canandaigua, New York, United States
Interlakes Oncology Hematology PC, Geneva, New York, United States
Cancer Center at Glens Falls Hospital, Glens Falls, New York, United States
New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program, Hudson, New York, United States
New York Oncology Hematology, PC, Latham, New York, United States
CCOP - North Shore University Hospital, Manhasset, New York, United States
CCOP, Long Island Jewish Medical Center, New Hyde Park, New York, United States
New York University School of Medicine, New York, New York, United States
New York Oncology Hematology PC, Rexford, New York, United States
Interlakes Oncology Hematology PC - White Spruce, Rochester, New York, United States
Interlakes Oncology Hematology PC- Long Pond, Rochester, New York, United States
University Hospital and Medical Center - SUNY Stony Brook, Stony Brook, New York, United States
Troy Cancer Treatment Program, Troy, New York, United States
Alamance Regional Medical Center, Burlington, North Carolina, United States
Cancer Centers of North Carolina, Cary, North Carolina, United States
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States
CCOP Carolinas HealthCare System, Charlotte, North Carolina, United States
Presbyterian Hospital, Charlotte, North Carolina, United States
Regional Cancer Care, PA, Durham, North Carolina, United States
Virginia Oncology Associates, Elizabeth City, North Carolina, United States
Cape Fear Valley Medical Center Cancer Center, Fayetteville, North Carolina, United States
Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States
CCOP, Moses Cone Health System-Regional CA Cntr, Greensboro, North Carolina, United States
East Carolina University, Greenville, North Carolina, United States
Margaret R. Pardee Memorial Hospital, Hendersonville, North Carolina, United States
High Point Regional Hospital, High Point, North Carolina, United States
Cancer Centers of North Carolina, Raleigh, North Carolina, United States
Cancer Centers of North Carolina- North Raleigh, Raleigh, North Carolina, United States
CCOP Forsyth Memorial Hospital, Winston-Salem, North Carolina, United States
Innovis Health, Fargo, North Dakota, United States
Akron City Hospital, Akron, Ohio, United States
Aultman Hospital, Canton, Ohio, United States
SCRI Oncology Hematology Care, Inc. - Cincinnati (TFT), Cincinnati, Ohio, United States
SCRI Oncology Hematology Care, Inc - Cincinnati (AND), Cincinnati, Ohio, United States
SCRI Oncology Hematology Care, Inc. - Cincinnati (KWD), Cincinnati, Ohio, United States
SCRI Oncology Hematlogy Care, Inc. - Cincinnati (RPR), Cincinnati, Ohio, United States
SCRI Oncology Hematology Care, Inc - Cincinnati (BAM), Cincinnati, Ohio, United States
SCRI Oncology Hematology Care, Inc. Cincinnati (WST), Cincinnati, Ohio, United States
Good Samaritan Hospital, Dayton, Ohio, United States
CCOP - Dayton, Dayton, Ohio, United States
HemOnc Care, Inc., Fairfield, Ohio, United States
Atrium Medical Center - Middletown Regional Hosp, Franklin, Ohio, United States
Wayne Hospital, Greenville, Ohio, United States
SCRI Oncology Hematology Care, Inc. - Hamilton (HAM), Hamilton, Ohio, United States
Greater Dayton Cancer Center, Kettering, Ohio, United States
Kettering Medical Center, Kettering, Ohio, United States
Upper Valley Medical Center, Troy, Ohio, United States
Clinton Memorial Hospital, Wilmington, Ohio, United States
SCRI Oncology Hematology Care, Inc. - Wilmington (WLM), Wilmington, Ohio, United States
St. Charles Medical Center - Bend, Bend, Oregon, United States
Willamette Valley Cancer Institute and Research Center, Eugene, Oregon, United States
Northwest Cancer Specialists-Portland, Portland, Oregon, United States
Providence Medical Center, Portland, Oregon, United States
Northwest Cancer Specialists- St. Vincent, Portland, Oregon, United States
Providence St. Vincent Medical Center, Portland, Oregon, United States
Northwest Cancer Specialists- Rose Qtr, Portland, Oregon, United States
Williamette Valley Cancer Institute and Research Center, Springfield, Oregon, United States
Celilo Center for Cancer Care, The Dalles, Oregon, United States
Northwest Cancer Specialists-Tualatin, Tualatin, Oregon, United States
Geisinger Clinic, Danville, Pennsylvania, United States
Oncology Hematology Associates of Northern PA, DuBois, Pennsylvania, United States
Pocono Medical Center, East Stroudsburg, Pennsylvania, United States
Ephrata Community Hopital, Ephrata, Pennsylvania, United States
Geisinger Hazleton Cancer Center, Hazleton, Pennsylvania, United States
Medical Oncology Associates, Kingston, Pennsylvania, United States
Riddle Memorial Hospital, Media, Pennsylvania, United States
Rittenhouse Hematology/Oncology, Philadelphia, Pennsylvania, United States
Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States
Albert Einstein Healthcare Network, Philadelphia, Pennsylvania, United States
Allegheny General Hospital/Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States
University of Pittsburgh, Pittsburgh, Pennsylvania, United States
Hematology and Oncology Associates of NEPA, Scranton, Pennsylvania, United States
Scranton Hematology Oncology, Scranton, Pennsylvania, United States
Geisinger Medical Group - Scenery Park, State College, Pennsylvania, United States
Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center, Upland, Pennsylvania, United States
Reading Hospital and Medical Center, West Reading, Pennsylvania, United States
Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States
AnMed Health Cancer Center, Anderson, South Carolina, United States
Roper Hosp & Med Asso (Care Alliance Health), Charleston, South Carolina, United States
Medical University of South Carolina, Charleston, South Carolina, United States
SCRI - South Carolina Oncology Associates - Stoneridge, Columbia, South Carolina, United States
Cancer Centers of the Carolinas Easley, SC, Easley, South Carolina, United States
Georgetown Hospital System, Georgetown, South Carolina, United States
Cancer Centers of the Carolinas (Butternut), Greenville, South Carolina, United States
Cancer Centers of the Carolinas-W. Faris Road, Greenville, South Carolina, United States
Cancer Centers of the Carolinas (International), Greenville, South Carolina, United States
Cancer Centers of the Carolinas - Seneca, Seneca, South Carolina, United States
Spartanburg Regional Healthcare System, Spartanburg, South Carolina, United States
Cancer Centers of the Carolinas - Spartanburg, Spartanburg, South Carolina, United States
Avera McKenna Hospital, Sioux Falls, South Dakota, United States
Avera Cancer Institute, Sioux Falls, South Dakota, United States
CCOP, Sanford Cancer Center - Oncology Clinic, Sioux Falls, South Dakota, United States
SCRI Chattanooga Oncol & Hematol Assoc, PC - Chattanooga, Chattanooga, Tennessee, United States
SCRI Tennessee Oncology - PLLC Franklin, Franklin, Tennessee, United States
SCRI Tennessee Oncology- Gallatin, Gallatin, Tennessee, United States
SCRI Tennessee Oncology, PLLC Hermitage, Hermitage, Tennessee, United States
SCRI Chattanooga Oncol & Hematol Assoc, PC Hixson, Hixson, Tennessee, United States
CCOP Holston Valley Medical Center, Kingsport, Tennessee, United States
SCRI Tennessee Oncology Lebanon, Lebanon, Tennessee, United States
SCRI Tennessee Oncology Murfreesboro, Murfreesboro, Tennessee, United States
SCRI - Tennessee Oncology PLLC, Nashville, Tennessee, United States
SCRI Tennessee Oncology, PLLC (Harding), Nashville, Tennessee, United States
SCRI Tennessee Onclogy, PLLC (Dickerson), Nashville, Tennessee, United States
SCRI - Tennessee Oncology PLLC, Nashville, Tennessee, United States
SCRI Tennessee Oncology, PLLC (Wallace), Nashville, Tennessee, United States
Tennessee Oncology, Shelbyville, Tennessee, United States
SCRI Tennessee Oncology, PLLC Smyrna, Smyrna, Tennessee, United States
Texas Cancer Center - Abilene South, Abilene, Texas, United States
Texas Oncology PA - Amarillo, Amarillo, Texas, United States
Texas Oncology PA - Arlington North, Arlington, Texas, United States
Texas Onclogy - Arlington South, Arlington, Texas, United States
Texas Oncology Central Austin, Austin, Texas, United States
Texas Oncology Cancer Center - Balcones, Austin, Texas, United States
South Austin Cancer Center, Austin, Texas, United States
Southwest Regional Cancer Center- North, Austin, Texas, United States
Texas Oncology North Austin- Renfert, Austin, Texas, United States
Mamie McFaddin Ward Cancer Center, Beaumont, Texas, United States
Edwards Cancer Center - Bedford, Bedford, Texas, United States
Texas Oncology PA - Harris HEB, Bedford, Texas, United States
Texas Oncology, PA - Cedar Park, Cedar Park, Texas, United States
Texas Cancer Center at Medical City, Dallas, Texas, United States
Texas Oncology PA- Presbyterian, Dallas, Texas, United States
Methodist Charlton Cancer Center, Dallas, Texas, United States
Texas Oncology- Sammons CC, Dallas, Texas, United States
Texas Cancer Center, Denton, Texas, United States
El Paso Cancer Treatment Center - West, El Paso, Texas, United States
El Paso Cancer Treatment Center - East, El Paso, Texas, United States
Texas Oncology - 8th Avenue, Fort Worth, Texas, United States
Texas Oncology at Klabzuba, Fort Worth, Texas, United States
Texas Oncology PA - 12th Avenue, Fort Worth, Texas, United States
Southwest Fort Worth Cancer Center, Fort Worth, Texas, United States
San Antonio Tumor and Blood Clinic, Fredericksburg, Texas, United States
Texas Oncology PA, Garland, Texas, United States
Texas Oncology, Grapevine, Texas, United States
Texas Oncology PA - Frostwood, Houston, Texas, United States
MD Anderson Cancer Center, Houston, Texas, United States
San Antonio Tumor and Blood Clinic, Kerrville, Texas, United States
Lake Vista Cancer Center, Lewisville, Texas, United States
Longview Cancer Center, Longview, Texas, United States
Joe Arrington Cancer Research & Treatment Center, Lubbock, Texas, United States
South Texas Cancer Center - McAllen, McAllen, Texas, United States
Texas Cancer Center of Mesquite, Mesquite, Texas, United States
Allison Cancer Center, Midland, Texas, United States
HOAST - New Braunfels, New Braunfels, Texas, United States
Texas Oncology - Odessa, Odessa, Texas, United States
Paris Regional Cancer Center, Paris, Texas, United States
North Texas Regional Cancer Center, Plano, Texas, United States
Texas Oncology Plano West Cancer Center, Plano, Texas, United States
Texas Oncology Seton Williamson, Round Rock, Texas, United States
Texas Oncology - Round Rock Cancer Center, Round Rock, Texas, United States
Cancer Care Centers of South Texas- Brooklyn, San Antonio, Texas, United States
Cancer Care Centers of South Texas - Loop 410, San Antonio, Texas, United States
HOAST - Medical Drive, San Antonio, Texas, United States
San Antonio Tumor and Blood Clinic - M.Oak, San Antonio, Texas, United States
University of Texas Health Science Center, San Antonio, Texas, United States
Texas Oncology - San Marcos, San Marcos, Texas, United States
Texas Cancer Center, Sherman, Texas, United States
Texas Oncology Cancer Center - Sugar Land, Sugar Land, Texas, United States
US Oncology, The Woodlands, Texas, United States
Tyler Cancer Center, Tyler, Texas, United States
Texas Oncology Cancer Care and Research Center, Waco, Texas, United States
Texas Oncology - Clear Lake, Webster, Texas, United States
South Texas Cancer Clinic, Weslaco, Texas, United States
Texoma Cancer Center, Wichita Falls, Texas, United States
Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States
McKay-Dee Hospital Center, Ogden, Utah, United States
Utah Valley Regional Medical Center - Provo, Provo, Utah, United States
Dixie Regional Medical Center - East Campus, Saint George, Utah, United States
Huntsman Cancer Inst. at the University of Utah- Salt Lake City, Salt Lake City, Utah, United States
LDS Hospital, Salt Lake City, Utah, United States
Southwestern Regional Cancer Center (SWORD), Bennington, Vermont, United States
Arlington Fairfax Hematology Oncology, Arlington, Virginia, United States
Virginia Oncology Associates - Medical Pkwy, Chesapeake, Virginia, United States
Oncology and Hematology Associates of SW VA, Inc, Christiansburg, Virginia, United States
Fairfax Northern VA Hematology-Oncology PC, Fairfax, Virginia, United States
Fair Oaks Office, Fairfax, Virginia, United States
Fairfax-Northern Virginia Hematology-Oncology PC, Gainesville, Virginia, United States
Virginia Oncology Associates, Hampton, Virginia, United States
Fairfax-Northern Virginia Hematology-Oncology PC, Leesburg, Virginia, United States
SCRI Virginia Cancer Institute (Flank), Mechanicsville, Virginia, United States
SCRI Virginia Cancer Institute, Midlothian, Virginia, United States
Virginia Oncology Associates, Newport News, Virginia, United States
Virginia Oncology Associates - Lake Wright, Norfolk, Virginia, United States
SCRI Virginia Cancer Institute (6605), Richmond, Virginia, United States
SCRI Virginia Cancer Institute (1401), Richmond, Virginia, United States
MBCCOP, Virginia Commonwealth University, Richmond, Virginia, United States
Oncology and Hematology Associates of SW VA, Inc, Roanoke, Virginia, United States
Oncology and Hematology Associates of SW VA, Inc, Salem, Virginia, United States
Virginia Oncology Associates, Virginia Beach, Virginia, United States
Virginia Oncology Associates, Williamsburg, Virginia, United States
Fairfax Northern Virginia Hematology-Oncology - Winchester, Winchester, Virginia, United States
Fairfax-Northern Virginia Hematology-Oncology PC, Woodbridge, Virginia, United States
Oncology and Hematology Associates of SW VA, Inc, Wytheville, Virginia, United States
Highline Medical Oncology, Burien, Washington, United States
Puget Sound Cancer Center- Edmonds, Edmonds, Washington, United States
Columbia Basin Hematology and Oncology, Kennewick, Washington, United States
Fred Hutchinson Cancer Research Center, Seattle, Washington, United States
Puget Sound Cancer Center - Seattle, Seattle, Washington, United States
Cancer Care Northwest-South, Spokane, Washington, United States
Rockwood Clinic Cancer Treatment Center, Spokane, Washington, United States
Cancer Care Northwest-Radiation Therapy (XRT), Spokane, Washington, United States
Cancer Care Northwest- Valley - Mission, Spokane, Washington, United States
Cancer Care Northwest-North - Holland, Spokane, Washington, United States
Evergreen Hematology & Oncology (Farwell), Spokane, Washington, United States
Northwest Cancer Specialists-136th Ave, Vancouver, Washington, United States
Northwest Cancer Specialists-134th St., Vancouver, Washington, United States
Yakima Valley Memorial Hospital - North Star Lodge, Yakima, Washington, United States
Raleigh Regional Cancer Center, Beckley, West Virginia, United States
CAMC Health Education & Research Institute, Inc., Charleston, West Virginia, United States
West Virginia University Hospitals Inc., Morgantown, West Virginia, United States
Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States
Wheeling Hospital, Wheeling, West Virginia, United States
Marshfield Clinic Chippewa Falls Center, Chippewa Falls, Wisconsin, United States
Marshfield Clinic Regional CA Cntr - Sacred Heart Hospital, Eau Claire, Wisconsin, United States
CCOP, St. Vincent Hospital, Green Bay, Wisconsin, United States
CCOP, St. Mary's Hospital Medical Center, Green Bay, Wisconsin, United States
CCOP - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States
Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States
Froedtert Hospital, Milwaukee, Wisconsin, United States
Medical College of Wisconsin, Milwaukee, Wisconsin, United States
Marshfield Clinic Minocqua Center, Minocqua, Wisconsin, United States
Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States
Marshfield Clinic at James Beck Cancer Center, Rhinelander, Wisconsin, United States
Marshfield Clinic Rice Lake Center, Rice Lake, Wisconsin, United States
Marshfield Clinic Cancer Care at St. Michael's Hospital, Stevens Point, Wisconsin, United States
Aspirus Regional Cancer Center, Wausau, Wisconsin, United States
Aurora Women's Pavilion of Aurora West Allis Medical Center, West Allis, Wisconsin, United States
CCOP Marshfield Clinic - Weston Center, Weston, Wisconsin, United States
Marshfield Clinic Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States
Bon Secours Hospital, Cork, CK, Ireland
Letterkenny General Hospital, Letterkenny, DL, Ireland
Mater Private Hospital, Dublin, DN, Ireland
Beaumont Hospital, Dublin, , Ireland
St. Vincent's University Hospital, Dublin, , Ireland
Mater Misericordiae, Dublin, , Ireland
St James' Hospital, Dublin, , Ireland
St. James' Hospital, Dublin, , Ireland
University College Hospital, Galway, , Ireland
Sligo General Hospital, Sligo, , Ireland
Waterford Regional Hospital, Waterford, , Ireland
Name: Norman Wolmark, MD
Affiliation: NSABP Foundation Inc
Role: PRINCIPAL_INVESTIGATOR