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Spots Global Cancer Trial Database for A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: A Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Official Title: A Phase III Clinical Trial Comparing the Combination of TC Plus Bevacizumab to TC Alone and to TAC for Women With Node-Positive or High-Risk Node-Negative, HER2-Negative Breast Cancer

Study ID: NCT00887536

Conditions

Breast Cancer

Study Description

Brief Summary: The main purpose of this study is to learn if adding bevacizumab to standard treatment with chemotherapy (docetaxel, doxorubicin, and cyclophosphamide) for early stage HER2-negative breast cancer will prevent breast cancer from returning. A second purpose of this study is to learn if adding bevacizumab to treatment with chemotherapy will help women with HER2-negative breast cancer live longer. The researchers also want to learn about the side effects of the combination of drugs used in this study.

Detailed Description: The B-46-I/07132 study, a multicenter, open-label, randomized Phase III, adjuvant therapy trial, will compare the value of adding bevacizumab to a non-anthracycline-based chemotherapy regimen relative to the same chemotherapy without bevacizumab and relative to an anthracycline-based chemotherapy regimen in women with resected node-positive or high-risk node-negative, HER2-negative breast cancer. This trial will determine whether the addition of bevacizumab to a regimen of docetaxel and cyclophosphamide (TCB) improves invasive disease-free survival relative to docetaxel and cyclophosphamide alone (TC). A secondary aim will be to determine whether the addition of bevacizumab to TC improves invasive disease-free survival compared to a regimen of docetaxel, doxorubicin, and cyclophosphamide (TAC). Other secondary aims include whether TCB improves disease-free survival, overall survival, and recurrence-free interval relative to TC alone and to TAC. The toxicities of the three regimens will also be compared. Patients in the B-46-I/07132 study will be randomized to one of three treatment regimens: Group 1 patients will receive 6 cycles of TAC administered every 21 days (docetaxel 75 mg/m2, doxorubicin 50 mg/m2, and cyclophosphamide 500 mg/m2); Group 2 patients will receive 6 cycles of TC administered every 21 days (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2); and Group 3 patients will receive 6 cycles of TCB every 21 days with bevacizumab therapy continuing every 21 days after completion of chemotherapy until 1 year following the first dose (docetaxel 75 mg/m2, cyclophosphamide 600 mg/m2, and bevacizumab 15 mg/kg). Primary prophylaxis with pegfilgrastim or filgrastim is required for Group 1 patients (optional for patients in Groups 2 and 3). Patients will also receive adjuvant radiation therapy as clinically indicated and endocrine therapy for hormone receptor-positive tumors. Tumor samples will be submitted for correlative science studies to evaluate predictors of study therapy benefit. Submission of a tumor sample is a study requirement for all patients.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Birmingham Hematology and Oncology, Bessemer, Alabama, United States

Birmingham Hematology and Oncology, Birmingham, Alabama, United States

Birmingham Hematology and Oncology - Brookwood, Birmingham, Alabama, United States

Birmingham Hematology and Oncology - Princeton, Birmingham, Alabama, United States

Birmingham Hematology and Oncology - Montclair, Birmingham, Alabama, United States

Birmingham Hematology and Oncology - Pilot, Birmingham, Alabama, United States

Clearview Cancer Institute- Huntsville, Huntsville, Alabama, United States

Northern Arizona Hematology & Onclogy Associates, Flagstaff, Arizona, United States

Arizona Oncolocy (CASA-Green Valley), Green Valley, Arizona, United States

Arizona Oncology (CASA- Oro Valley), Oro Valley, Arizona, United States

Hematology Oncology Associates, Phoenix, Arizona, United States

Northern Arizona Hematology & Oncology Associates, Prescott Valley, Arizona, United States

Arizona Oncology (CASA-Safford), Safford, Arizona, United States

Hematology Oncology Associates, Scottsdale, Arizona, United States

Northern Arizona Hematology & Oncology Associates, Sedona, Arizona, United States

Arizona Oncology Associates - Rudasill, Tucson, Arizona, United States

Arizona Oncology Associates - Carondelet, Tucson, Arizona, United States

Arizona Oncology (CASA-Craycroft), Tucson, Arizona, United States

Arizona Oncology (CASA-Office Only), Tucson, Arizona, United States

Arizona Oncology - CASA St. Mary's, Tucson, Arizona, United States

Central Hematology/Oncology Medical Group, Inc., Alhambra, California, United States

Kaiser Permanente Deer Valley Med Center, Antioch, California, United States

Comp Blook and Cancer Center, Bakersfield, California, United States

Southwest Cancer Care (E. Grand), Escondido, California, United States

Kaiser Permanente Fremont, Fremont, California, United States

St. Jude Heritage Healthcare, Fullerton, California, United States

Kaiser Permanente Medical Center - Hayward, Hayward, California, United States

Pacific Shores Medical Group, Huntington Beach, California, United States

Southern California Permanente Medical Group, Irvine, California, United States

Wilshire Oncology Medical Group (Business Office), La Verne, California, United States

Antelope Valley Cancer Center, Lancaster, California, United States

Breastlink Medical Group, Incorporated at Long Beach Memorial Medical Center, Long Beach, California, United States

Todd Cancer Institute at Long Beach Memorial Med Cent, Long Beach, California, United States

Pacific Shores Medical Group, Long Beach, California, United States

Pacific Shores Medical Group, Los Alamitos, California, United States

TORI- N Valley Hematology Oncology Med Group, Mission Hills, California, United States

TORI - Oncology Care Medical Assoc., Montebello, California, United States

Southwest Cancer Care (Medical Center), Murrieta, California, United States

NValley Hematology/Oncology Medical Group, Northridge, California, United States

Kaiser Permanente-Oakland, Oakland, California, United States

St. Joseph Hospital, Orange, California, United States

Ventura County Hematology-Oncology Specialists, Oxnard, California, United States

Stanford University Medical Center, Palo Alto, California, United States

Kaiser Permanente Medical Center - Redwood City, Redwood City, California, United States

Kaiser Permanente Medical Center - Richmond, Richmond, California, United States

Sutter Roseville Medical Center, Roseville, California, United States

Kaiser Permanente Roseville, Roseville, California, United States

Sutter Medical Center, Sacramento, California, United States

Kaiser Permanente, South Sacramento, Sacramento, California, United States

Kaiser Permanente Medical Center - Sacramento, Sacramento, California, United States

Kaiser Permanente-San Diego, San Diego, California, United States

Kaiser Permanente Medical Center - San Francisco Geary Campus, San Francisco, California, United States

TORI - Oncology Care Med Assoc, San Gabriel, California, United States

Kaiser Permanente Santa Teresa, San Jose, California, United States

Kaiser Permanente San Rafael, San Rafael, California, United States

Santa Barbara Hematology Oncology Medical Group, Santa Barbara, California, United States

Santa Barbara II (Samsum Clinic) - TORI, Santa Barbara, California, United States

Kaiser Permanente Medical Center - Santa Clara Kiely Campus, Santa Clara, California, United States

Central Coast Medical Oncology Corporation, Santa Maria, California, United States

Kaiser Permanente Medical Center - Santa Rosa, Santa Rosa, California, United States

Santa Barbara Hematology/Oncology Medical Group, Inc, Solvang, California, United States

Kaiser Permanente-South San Francisco, South San Francisco, California, United States

Kaiser Permanente Medical Facility - Stockton, Stockton, California, United States

Olive View/UCLA Medical Center, Sylmar, California, United States

Kaiser Permanente Medical Center Vacaville, Vacaville, California, United States

Kaiser Permanente Medical Center - Vallejo, Vallejo, California, United States

Kaiser Permanente Medical Center - Walnut Creek, Walnut Creek, California, United States

Trivalley Oncology Hematology, Westlake Village, California, United States

Westlake Infusion Center, Westlake Village, California, United States

TORI - Oncology Care Med Assoc, Whittier, California, United States

Medical Center of Aurora, Aurora, Colorado, United States

Rocky Mountain Cancer Center, Aurora, Colorado, United States

Rocky Mountain Cancer Centers - Boulder, Boulder, Colorado, United States

Penrose/St. Francis Healthcare System, Colorado Springs, Colorado, United States

Rocky Mountain Cancer Center at the Pivillion- Fontanero, Colorado Springs, Colorado, United States

Rocky Mountain Cancer Center - CO Springs, Colorado Springs, Colorado, United States

Kaiser Permanente-Franklin, Denver, Colorado, United States

CCOP - Colorado Cancer Research Program, Inc., Denver, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Exempla St. Joseph Hospital, Denver, Colorado, United States

Rocky Mountain Cancer Center - Midtown, Denver, Colorado, United States

Rocky Mountain Cancer Center - 9th Avenue, Denver, Colorado, United States

Rocky Mountain Cancer Center - Rose, Denver, Colorado, United States

University of Colorado, Denver, Colorado, United States

Shaw Regional Cancer Center, Edwards, Colorado, United States

Swedish Medical Center, Englewood, Colorado, United States

Front Range Cancer Specialists, Fort Collins, Colorado, United States

Poudre Valley Hospital, Fort Collins, Colorado, United States

St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States

St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction, Colorado, United States

North Colorado Medical Center, Greeley, Colorado, United States

Kaiser Permanente Rock Creek, Lafayette, Colorado, United States

Rocky Mountain Cancer Center, Lakewood, Colorado, United States

Rocky Mountain Cancer Center - Dry Creek, Littleton, Colorado, United States

Rocky Mountain Cancer Center- Sky Ridge, Lone Tree, Colorado, United States

Rocky Mountain Cancer Center - Longmont, Longmont, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

Rocky Mountain Cancer Center, Parker, Colorado, United States

Rocky Mountain Cancer Centers, Thornton, Colorado, United States

Exempla Lutheran Medical Center, Wheat Ridge, Colorado, United States

University of Connecticut, Farmington, Connecticut, United States

Hartford Hospital, Hartford, Connecticut, United States

Washington Regional Cancer Center, Washington, District of Columbia, United States

Sibley Memorial Hospital, Washington, District of Columbia, United States

SCRI - Florida Cancer Specialists- Bonita Springs, Bonita Springs, Florida, United States

SCRI - Florida Cancer Specialists - Bradenton, Bradenton, Florida, United States

Florida Cancer Specialists, Brandon, Florida, United States

SCRI Florida Cancer Specialists - Cape Coral (1708), Cape Coral, Florida, United States

SCRI Florida Cancer Specialists - Cape Coral (811), Cape Coral, Florida, United States

Morton Plant Mease Health Care, Clearwater, Florida, United States

SCRI Florida Cancer Specialists - Englewood, Englewood, Florida, United States

Holy Cross Hospital, Fort Lauderdale, Florida, United States

SCRI Florida Cancer Specialists - Fort Myers (Hampshire), Fort Myers, Florida, United States

SCRI Florida Cancer Specialists - Ft. Myers (Broadway), Fort Myers, Florida, United States

SCRI Florida Cancer Specialists- Fort Myers (Veronica), Fort Myers, Florida, United States

University of Florida Shands Cancer Center, Gainesville, Florida, United States

Florida Cancer Institute - New Hope, Hudson, Florida, United States

TORI-ICON - Shircl, Jacksonville, Florida, United States

Baptist Cancer Institute - Jacksonville, Jacksonville, Florida, United States

Integrated Community Oncology Network (ICON), Jacksonville, Florida, United States

TORI-ICON St.Aug, Jacksonville, Florida, United States

CCOP, Jupiter Medical Cener, Jupiter, Florida, United States

Ocala Oncology Center - Lady Lake, Lady Lake, Florida, United States

Melbourne International Medicine Associates, Melbourne, Florida, United States

CCOP - Mount Sinai Medical Center, Miami Beach, Florida, United States

Advanced Medical Specialties - AMS, Miami, Florida, United States

Advanced Medical Specialists- Sunset, Miami, Florida, United States

Advanced Medical Specialties - N Kendall (STE 300E), Miami, Florida, United States

Advanced Medical Specialties - N. Kendall (STE 905E), Miami, Florida, United States

SCRI Florida Cancer Specialists - Naples (Goodlette), Naples, Florida, United States

SCRI Florida Cancer Specialists - Naples (Pine), Naples, Florida, United States

Florida Cancer Institute - New Hope, New Port Richey, Florida, United States

Ocala Oncology Center, Ocala, Florida, United States

Cancer Centers of Florida, P.A., Ocoee, Florida, United States

Tori-Icon, Orange Park, Florida, United States

Florida Hospital, Orlando, Florida, United States

Cancer Centers of Florida, P.A., Orlando, Florida, United States

MD Anderson Cancer Center, Orlando, Florida, United States

SCRI - Florida Cancer Specialists - Port Charlotte, Port Charlotte, Florida, United States

Tori-Icon, Saint Augustine, Florida, United States

SCRI Florida Cancer Specialists - Sarasota (Cattleman), Sarasota, Florida, United States

SCRI- Florida Cancer Specialists - Sarasota, Sarasota, Florida, United States

SCRI - Florida Cancer Specialists - Armenia, Tampa, Florida, United States

SCRI - Florida Cancer Specialists - Tampa, Tampa, Florida, United States

SCRI Florida Cancer Specialists - Venice (Tamiami), Venice, Florida, United States

SCRI Florida Cancer Specilaists - Venice, Venice, Florida, United States

Cancer Centers of Florida, P.A., Winter Park, Florida, United States

Phoebe Putney Memorial Hospital, Albany, Georgia, United States

Northwest Georgia Oncology Centers, Austell, Georgia, United States

Northwest Georgia Oncology Centers, Carrollton, Georgia, United States

Dublin Hematology/Oncology, Dublin, Georgia, United States

Suburban Hematology-Oncology Associates, Lawrenceville, Georgia, United States

Northwest Georgia Oncology Centers, Marietta, Georgia, United States

SCRI Chattanooga Oncol & Hematol Assoc, PC - Ringgold, Ringgold, Georgia, United States

Memorial Health University Medical Center, Savannah, Georgia, United States

University of Hawaii, Honolulu, Hawaii, United States

Kaiser Permanente Hawaii - Moanalua Med Center, Honolulu, Hawaii, United States

Cancer Care & Hematology Specialists of Chicagoland, Arlington, Illinois, United States

Rush University Medical Center, Chicago, Illinois, United States

Decatur Memorial Hospital Cancer Care Institute, Decatur, Illinois, United States

CCOP NorthShore University HealthSystem, Evanston, Illinois, United States

Ingalls Memorial Hospital, Harvey, Illinois, United States

Hinsdale Hematology Oncology Associates, Hinsdale, Illinois, United States

Edward Hospital, Naperville, Illinois, United States

Cancer Care & Hematology Specialists of Chicagoland, Niles, Illinois, United States

Advocate Lutheran General Cancer Care Center, Park Ridge, Illinois, United States

Carle Cancer Center, CCOP, Urbana, Illinois, United States

Carle Foundation Hospital, Urbana, Illinois, United States

Cancer Care and Hematology Specialists of Chicagoland, Winfield, Illinois, United States

Central Indiana Cancer Centers, Carmel, Indiana, United States

Central Indiana Cancer Centers, Fishers, Indiana, United States

Central Indiana Cancer Centers, Greenfield, Indiana, United States

Central Indiana Cancer Centers, Indianapolis, Indiana, United States

Central Indiana Cancer Centers (E. County), Indianapolis, Indiana, United States

St. Vincent Hospital and Health Care Center, Indianapolis, Indiana, United States

Clarian Arnett Cancer Care, Lafayette, Indiana, United States

Community Hospital, Munster, Indiana, United States

Genesis Medical Center, Davenport, Iowa, United States

Finley Hospital, Dubuque, Iowa, United States

University of Iowa, Iowa City, Iowa, United States

Mercy Medical Center - Sioux City, Sioux City, Iowa, United States

Siouxland Hematology-Oncology Associates, Sioux City, Iowa, United States

St. Luke's Regional Medical Center, Sioux City, Iowa, United States

Covenant Cancer Treatment Center, Waterloo, Iowa, United States

Kansas Cty Cancer Center - West, Kansas City, Kansas, United States

Menorah Medical Center, Overland Park, Kansas, United States

Kansas City Cancer Center (CBO), Overland Park, Kansas, United States

Kansas CityCancer Centers - Southwest, Overland Park, Kansas, United States

Kansas City Cancer Center, Shawnee Mission, Shawnee Mission, Kansas, United States

SCRI Oncology Hematology Care, Inc. Crestview Hills (CVH), Crestview Hills, Kentucky, United States

University of Kentucky Medical Center, Lexington, Kentucky, United States

NortonHealtcare Inc., Louisville, Kentucky, United States

Consultants in Blood Disorders and Cancer, Louisville, Kentucky, United States

Christus St. Frances Cabrini Hospital, Alexandria, Louisiana, United States

Baton Rouge General Medical Center, Baton Rouge, Louisiana, United States

Tulane University Medical Center, New Orleans, Louisiana, United States

Eastern Maine Medical Center, Bangor, Maine, United States

Mercy Medical Center, Baltimore, Maryland, United States

St. Joseph's Medical Center, Baltimore, Maryland, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

Franklin Square Hospital Center, Baltimore, Maryland, United States

SCRI - Center for Cancer and Blood Disorders, Bethesda, Maryland, United States

Suburban Hospital, Bethesda, Maryland, United States

Chevy Chase Healthcare Management, LLC, Chevy Chase, Maryland, United States

Maryland Oncology Hematology PA, Columbia, Maryland, United States

Frederick Memorial Hospital, Frederick, Maryland, United States

Alliance Hematology Oncology PA, Owings Mills, Maryland, United States

Penisula Regional Medical Center, Salisbury, Maryland, United States

Holy Cross Hospital, Silver Spring, Maryland, United States

Alliance Hematology Oncology PA, Westminster, Maryland, United States

Saint Anne's Hospital, Fall River, Massachusetts, United States

Berkshire Hematology Oncology, P.C., Pittsfield, Massachusetts, United States

CCOP, St. Joseph Mercy Hospital, Ann Arbor, Michigan, United States

Bay Regional Medical Center, Bay City, Michigan, United States

CCOP - Oakwood Hospital and Medical Center, Dearborn, Michigan, United States

Henry Ford Health System, Detroit, Michigan, United States

CCOP - St. John Hospital and Medical Center, Detroit, Michigan, United States

Michigan State University, East Lansing, Michigan, United States

CCOP - Genesys Regional Hospital, Flint, Michigan, United States

CCOP - Hurley Medical Center, Flint, Michigan, United States

McLaren Regional Medical Center, Flint, Michigan, United States

CCOP - Allegiance Health, Jackson, Michigan, United States

Borgess Medical Center, Kalamazoo, Michigan, United States

Bronson Methodist Hospital, Kalamazoo, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

Ingham Regional Medical Center - Lansing, Lansing, Michigan, United States

CCOP, Sparrow Health System, Lansing, Michigan, United States

Lapeer Regional Hospital, Lapeer, Michigan, United States

CCOP - St. Mary Mercy Hospital - Livonia, Livonia, Michigan, United States

Marquette General Hospital, Marquette, Michigan, United States

Mount Clemens Regional Medical Center, Mount Clemens, Michigan, United States

Memorial Healthcare, Owosso, Michigan, United States

CCOP - St. Joseph Mercy Hospital - Oakland, Pontiac, Michigan, United States

CCOP - St. Joseph Mercy Port Huron, Port Huron, Michigan, United States

CCOP, William Beaumont Hospital, Royal Oak, Michigan, United States

CCOP, St. Mary's Medical Center, Saginaw, Michigan, United States

Providence Hospital - Southfield, Southfield, Michigan, United States

CCOP, St. John Macomb Hospital, Warren, Michigan, United States

Minnesota Oncology Hematology-Burnsville, Burnsville, Minnesota, United States

Mercy and Unity Cancer Center at Mercy Hospital, Coon Rapids, Minnesota, United States

St. Luke's Hospital, Duluth, Minnesota, United States

Fairview Southdale Hospital, Edina, Minnesota, United States

Minnesota Oncology Hematology-Edina, Edina, Minnesota, United States

Unity Hospital, Fridley, Minnesota, United States

Minnesota Oncology Hematology PA - Maplewood, Maplewood, Minnesota, United States

St. John's Hospital Northeast/HealthEast, Inc., Maplewood, Minnesota, United States

Minnesota Oncology Hematology-Minneapolis, Minneapolis, Minnesota, United States

Abbott-Northwestern Hospital, Minneapolis, Minnesota, United States

Hennepin County Medical Center - Minneapolis, Minneapolis, Minnesota, United States

North Memorial Health Care, Robbinsdale, Minnesota, United States

CCOP - Metro-Minnesota, Saint Louis Park, Minnesota, United States

Park Nicollet Health Services, Saint Louis Park, Minnesota, United States

Regions Hospital Cancer Care Center, Saint Paul, Minnesota, United States

Minnesota Hematology Oncology-St. Paul, Saint Paul, Minnesota, United States

Minnesota Oncology Hematology, Woodbury, Minnesota, United States

Missouri Cancer Associates, Columbia, Missouri, United States

University of Missouri-Ellis Fischel, Columbia, Missouri, United States

Kansas City Cancer Center - Central, Kansas City, Missouri, United States

Saint Luke's Hospital, Kansas City, Missouri, United States

CCOP - Kansas City, Kansas City, Missouri, United States

Kansas City Cancer Center - South, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

Research Medical Center, Kansas City, Missouri, United States

Kansas City Cancer Center - North, Kansas City, Missouri, United States

Kansas City Cancer Centers - East, Lee's Summit, Missouri, United States

St. Louis University Health Sciences Center, Saint Louis, Missouri, United States

Nebraska Cancer Research Center, Lincoln, Nebraska, United States

St. Elizabeth Community Health Center, Lincoln, Nebraska, United States

Alegent Health Immanuel Medical Center, Omaha, Nebraska, United States

Alegent Health Bergan Mercy Medical Center, Omaha, Nebraska, United States

CCOP, Missouri Valley Cance Consortium, Omaha, Nebraska, United States

Creighton University Cancer Center, Omaha, Nebraska, United States

Alegent Health Midlands Hospital, Papillion, Nebraska, United States

Comprehensive Cancer Centers of Nevada (Siena), Henderson, Nevada, United States

US Oncology West Region Office (Horizon Ridge), Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada (Wigwam), Henderson, Nevada, United States

Comprehensive Cancer Centers of Nevada (Peak Dr.), Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada (Southern Hills), Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada (Twain), Las Vegas, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Cancer Institute of New Jersey at Hamilton, Hamilton, New Jersey, United States

Hematology-Oncology Associates of NNJ, PA, Morristown, New Jersey, United States

Cancer Institute of New Jersey, New Brunswick, New Jersey, United States

Newark Beth Israel Medical Center, Newark, New Jersey, United States

Saint Clare's Center at Parsippany Commons, Parsippany, New Jersey, United States

Somerset Medical Center, Somerville, New Jersey, United States

Sparta Cancer Center, Sparta, New Jersey, United States

Texas Oncology PA Las Cruces, Las Cruces, New Mexico, United States

New Mexico Cancer Care Associates, Santa Fe, New Mexico, United States

New York Oncology Hematology PC-Albany, Albany, New York, United States

New York Oncology Hematology, PC at Albany Medical Center, Albany, New York, United States

Amsterdam Community Cancer Program, Amsterdam, New York, United States

Interlakes Oncology Hematology PC, Brockport, New York, United States

Interlakes Oncology & Hematology, P.C., Canandaigua, New York, United States

Interlakes Oncology Hematology PC, Geneva, New York, United States

Cancer Center at Glens Falls Hospital, Glens Falls, New York, United States

New York Oncology Hematology, P.C. at Cavell Cancer Treatment Program, Hudson, New York, United States

New York Oncology Hematology, PC, Latham, New York, United States

CCOP - North Shore University Hospital, Manhasset, New York, United States

CCOP, Long Island Jewish Medical Center, New Hyde Park, New York, United States

New York University School of Medicine, New York, New York, United States

New York Oncology Hematology PC, Rexford, New York, United States

Interlakes Oncology Hematology PC - White Spruce, Rochester, New York, United States

Interlakes Oncology Hematology PC- Long Pond, Rochester, New York, United States

University Hospital and Medical Center - SUNY Stony Brook, Stony Brook, New York, United States

Troy Cancer Treatment Program, Troy, New York, United States

Alamance Regional Medical Center, Burlington, North Carolina, United States

Cancer Centers of North Carolina, Cary, North Carolina, United States

University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States

CCOP Carolinas HealthCare System, Charlotte, North Carolina, United States

Presbyterian Hospital, Charlotte, North Carolina, United States

Regional Cancer Care, PA, Durham, North Carolina, United States

Virginia Oncology Associates, Elizabeth City, North Carolina, United States

Cape Fear Valley Medical Center Cancer Center, Fayetteville, North Carolina, United States

Wayne Memorial Hospital, Incorporated, Goldsboro, North Carolina, United States

CCOP, Moses Cone Health System-Regional CA Cntr, Greensboro, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

Margaret R. Pardee Memorial Hospital, Hendersonville, North Carolina, United States

High Point Regional Hospital, High Point, North Carolina, United States

Cancer Centers of North Carolina, Raleigh, North Carolina, United States

Cancer Centers of North Carolina- North Raleigh, Raleigh, North Carolina, United States

CCOP Forsyth Memorial Hospital, Winston-Salem, North Carolina, United States

Innovis Health, Fargo, North Dakota, United States

Akron City Hospital, Akron, Ohio, United States

Aultman Hospital, Canton, Ohio, United States

SCRI Oncology Hematology Care, Inc. - Cincinnati (TFT), Cincinnati, Ohio, United States

SCRI Oncology Hematology Care, Inc - Cincinnati (AND), Cincinnati, Ohio, United States

SCRI Oncology Hematology Care, Inc. - Cincinnati (KWD), Cincinnati, Ohio, United States

SCRI Oncology Hematlogy Care, Inc. - Cincinnati (RPR), Cincinnati, Ohio, United States

SCRI Oncology Hematology Care, Inc - Cincinnati (BAM), Cincinnati, Ohio, United States

SCRI Oncology Hematology Care, Inc. Cincinnati (WST), Cincinnati, Ohio, United States

Good Samaritan Hospital, Dayton, Ohio, United States

CCOP - Dayton, Dayton, Ohio, United States

HemOnc Care, Inc., Fairfield, Ohio, United States

Atrium Medical Center - Middletown Regional Hosp, Franklin, Ohio, United States

Wayne Hospital, Greenville, Ohio, United States

SCRI Oncology Hematology Care, Inc. - Hamilton (HAM), Hamilton, Ohio, United States

Greater Dayton Cancer Center, Kettering, Ohio, United States

Kettering Medical Center, Kettering, Ohio, United States

Upper Valley Medical Center, Troy, Ohio, United States

Clinton Memorial Hospital, Wilmington, Ohio, United States

SCRI Oncology Hematology Care, Inc. - Wilmington (WLM), Wilmington, Ohio, United States

St. Charles Medical Center - Bend, Bend, Oregon, United States

Willamette Valley Cancer Institute and Research Center, Eugene, Oregon, United States

Northwest Cancer Specialists-Portland, Portland, Oregon, United States

Providence Medical Center, Portland, Oregon, United States

Northwest Cancer Specialists- St. Vincent, Portland, Oregon, United States

Providence St. Vincent Medical Center, Portland, Oregon, United States

Northwest Cancer Specialists- Rose Qtr, Portland, Oregon, United States

Williamette Valley Cancer Institute and Research Center, Springfield, Oregon, United States

Celilo Center for Cancer Care, The Dalles, Oregon, United States

Northwest Cancer Specialists-Tualatin, Tualatin, Oregon, United States

Geisinger Clinic, Danville, Pennsylvania, United States

Oncology Hematology Associates of Northern PA, DuBois, Pennsylvania, United States

Pocono Medical Center, East Stroudsburg, Pennsylvania, United States

Ephrata Community Hopital, Ephrata, Pennsylvania, United States

Geisinger Hazleton Cancer Center, Hazleton, Pennsylvania, United States

Medical Oncology Associates, Kingston, Pennsylvania, United States

Riddle Memorial Hospital, Media, Pennsylvania, United States

Rittenhouse Hematology/Oncology, Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Albert Einstein Healthcare Network, Philadelphia, Pennsylvania, United States

Allegheny General Hospital/Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, United States

University of Pittsburgh, Pittsburgh, Pennsylvania, United States

Hematology and Oncology Associates of NEPA, Scranton, Pennsylvania, United States

Scranton Hematology Oncology, Scranton, Pennsylvania, United States

Geisinger Medical Group - Scenery Park, State College, Pennsylvania, United States

Associates in Hematology-Oncology, PC at Crozer Regional Cancer Center, Upland, Pennsylvania, United States

Reading Hospital and Medical Center, West Reading, Pennsylvania, United States

Geisinger Wyoming Valley Medical Center, Wilkes-Barre, Pennsylvania, United States

AnMed Health Cancer Center, Anderson, South Carolina, United States

Roper Hosp & Med Asso (Care Alliance Health), Charleston, South Carolina, United States

Medical University of South Carolina, Charleston, South Carolina, United States

SCRI - South Carolina Oncology Associates - Stoneridge, Columbia, South Carolina, United States

Cancer Centers of the Carolinas Easley, SC, Easley, South Carolina, United States

Georgetown Hospital System, Georgetown, South Carolina, United States

Cancer Centers of the Carolinas (Butternut), Greenville, South Carolina, United States

Cancer Centers of the Carolinas-W. Faris Road, Greenville, South Carolina, United States

Cancer Centers of the Carolinas (International), Greenville, South Carolina, United States

Cancer Centers of the Carolinas - Seneca, Seneca, South Carolina, United States

Spartanburg Regional Healthcare System, Spartanburg, South Carolina, United States

Cancer Centers of the Carolinas - Spartanburg, Spartanburg, South Carolina, United States

Avera McKenna Hospital, Sioux Falls, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

CCOP, Sanford Cancer Center - Oncology Clinic, Sioux Falls, South Dakota, United States

SCRI Chattanooga Oncol & Hematol Assoc, PC - Chattanooga, Chattanooga, Tennessee, United States

SCRI Tennessee Oncology - PLLC Franklin, Franklin, Tennessee, United States

SCRI Tennessee Oncology- Gallatin, Gallatin, Tennessee, United States

SCRI Tennessee Oncology, PLLC Hermitage, Hermitage, Tennessee, United States

SCRI Chattanooga Oncol & Hematol Assoc, PC Hixson, Hixson, Tennessee, United States

CCOP Holston Valley Medical Center, Kingsport, Tennessee, United States

SCRI Tennessee Oncology Lebanon, Lebanon, Tennessee, United States

SCRI Tennessee Oncology Murfreesboro, Murfreesboro, Tennessee, United States

SCRI - Tennessee Oncology PLLC, Nashville, Tennessee, United States

SCRI Tennessee Oncology, PLLC (Harding), Nashville, Tennessee, United States

SCRI Tennessee Onclogy, PLLC (Dickerson), Nashville, Tennessee, United States

SCRI - Tennessee Oncology PLLC, Nashville, Tennessee, United States

SCRI Tennessee Oncology, PLLC (Wallace), Nashville, Tennessee, United States

Tennessee Oncology, Shelbyville, Tennessee, United States

SCRI Tennessee Oncology, PLLC Smyrna, Smyrna, Tennessee, United States

Texas Cancer Center - Abilene South, Abilene, Texas, United States

Texas Oncology PA - Amarillo, Amarillo, Texas, United States

Texas Oncology PA - Arlington North, Arlington, Texas, United States

Texas Onclogy - Arlington South, Arlington, Texas, United States

Texas Oncology Central Austin, Austin, Texas, United States

Texas Oncology Cancer Center - Balcones, Austin, Texas, United States

South Austin Cancer Center, Austin, Texas, United States

Southwest Regional Cancer Center- North, Austin, Texas, United States

Texas Oncology North Austin- Renfert, Austin, Texas, United States

Mamie McFaddin Ward Cancer Center, Beaumont, Texas, United States

Edwards Cancer Center - Bedford, Bedford, Texas, United States

Texas Oncology PA - Harris HEB, Bedford, Texas, United States

Texas Oncology, PA - Cedar Park, Cedar Park, Texas, United States

Texas Cancer Center at Medical City, Dallas, Texas, United States

Texas Oncology PA- Presbyterian, Dallas, Texas, United States

Methodist Charlton Cancer Center, Dallas, Texas, United States

Texas Oncology- Sammons CC, Dallas, Texas, United States

Texas Cancer Center, Denton, Texas, United States

El Paso Cancer Treatment Center - West, El Paso, Texas, United States

El Paso Cancer Treatment Center - East, El Paso, Texas, United States

Texas Oncology - 8th Avenue, Fort Worth, Texas, United States

Texas Oncology at Klabzuba, Fort Worth, Texas, United States

Texas Oncology PA - 12th Avenue, Fort Worth, Texas, United States

Southwest Fort Worth Cancer Center, Fort Worth, Texas, United States

San Antonio Tumor and Blood Clinic, Fredericksburg, Texas, United States

Texas Oncology PA, Garland, Texas, United States

Texas Oncology, Grapevine, Texas, United States

Texas Oncology PA - Frostwood, Houston, Texas, United States

MD Anderson Cancer Center, Houston, Texas, United States

San Antonio Tumor and Blood Clinic, Kerrville, Texas, United States

Lake Vista Cancer Center, Lewisville, Texas, United States

Longview Cancer Center, Longview, Texas, United States

Joe Arrington Cancer Research & Treatment Center, Lubbock, Texas, United States

South Texas Cancer Center - McAllen, McAllen, Texas, United States

Texas Cancer Center of Mesquite, Mesquite, Texas, United States

Allison Cancer Center, Midland, Texas, United States

HOAST - New Braunfels, New Braunfels, Texas, United States

Texas Oncology - Odessa, Odessa, Texas, United States

Paris Regional Cancer Center, Paris, Texas, United States

North Texas Regional Cancer Center, Plano, Texas, United States

Texas Oncology Plano West Cancer Center, Plano, Texas, United States

Texas Oncology Seton Williamson, Round Rock, Texas, United States

Texas Oncology - Round Rock Cancer Center, Round Rock, Texas, United States

Cancer Care Centers of South Texas- Brooklyn, San Antonio, Texas, United States

Cancer Care Centers of South Texas - Loop 410, San Antonio, Texas, United States

HOAST - Medical Drive, San Antonio, Texas, United States

San Antonio Tumor and Blood Clinic - M.Oak, San Antonio, Texas, United States

University of Texas Health Science Center, San Antonio, Texas, United States

Texas Oncology - San Marcos, San Marcos, Texas, United States

Texas Cancer Center, Sherman, Texas, United States

Texas Oncology Cancer Center - Sugar Land, Sugar Land, Texas, United States

US Oncology, The Woodlands, Texas, United States

Tyler Cancer Center, Tyler, Texas, United States

Texas Oncology Cancer Care and Research Center, Waco, Texas, United States

Texas Oncology - Clear Lake, Webster, Texas, United States

South Texas Cancer Clinic, Weslaco, Texas, United States

Texoma Cancer Center, Wichita Falls, Texas, United States

Sandra L. Maxwell Cancer Center, Cedar City, Utah, United States

McKay-Dee Hospital Center, Ogden, Utah, United States

Utah Valley Regional Medical Center - Provo, Provo, Utah, United States

Dixie Regional Medical Center - East Campus, Saint George, Utah, United States

Huntsman Cancer Inst. at the University of Utah- Salt Lake City, Salt Lake City, Utah, United States

LDS Hospital, Salt Lake City, Utah, United States

Southwestern Regional Cancer Center (SWORD), Bennington, Vermont, United States

Arlington Fairfax Hematology Oncology, Arlington, Virginia, United States

Virginia Oncology Associates - Medical Pkwy, Chesapeake, Virginia, United States

Oncology and Hematology Associates of SW VA, Inc, Christiansburg, Virginia, United States

Fairfax Northern VA Hematology-Oncology PC, Fairfax, Virginia, United States

Fair Oaks Office, Fairfax, Virginia, United States

Fairfax-Northern Virginia Hematology-Oncology PC, Gainesville, Virginia, United States

Virginia Oncology Associates, Hampton, Virginia, United States

Fairfax-Northern Virginia Hematology-Oncology PC, Leesburg, Virginia, United States

SCRI Virginia Cancer Institute (Flank), Mechanicsville, Virginia, United States

SCRI Virginia Cancer Institute, Midlothian, Virginia, United States

Virginia Oncology Associates, Newport News, Virginia, United States

Virginia Oncology Associates - Lake Wright, Norfolk, Virginia, United States

SCRI Virginia Cancer Institute (6605), Richmond, Virginia, United States

SCRI Virginia Cancer Institute (1401), Richmond, Virginia, United States

MBCCOP, Virginia Commonwealth University, Richmond, Virginia, United States

Oncology and Hematology Associates of SW VA, Inc, Roanoke, Virginia, United States

Oncology and Hematology Associates of SW VA, Inc, Salem, Virginia, United States

Virginia Oncology Associates, Virginia Beach, Virginia, United States

Virginia Oncology Associates, Williamsburg, Virginia, United States

Fairfax Northern Virginia Hematology-Oncology - Winchester, Winchester, Virginia, United States

Fairfax-Northern Virginia Hematology-Oncology PC, Woodbridge, Virginia, United States

Oncology and Hematology Associates of SW VA, Inc, Wytheville, Virginia, United States

Highline Medical Oncology, Burien, Washington, United States

Puget Sound Cancer Center- Edmonds, Edmonds, Washington, United States

Columbia Basin Hematology and Oncology, Kennewick, Washington, United States

Fred Hutchinson Cancer Research Center, Seattle, Washington, United States

Puget Sound Cancer Center - Seattle, Seattle, Washington, United States

Cancer Care Northwest-South, Spokane, Washington, United States

Rockwood Clinic Cancer Treatment Center, Spokane, Washington, United States

Cancer Care Northwest-Radiation Therapy (XRT), Spokane, Washington, United States

Cancer Care Northwest- Valley - Mission, Spokane, Washington, United States

Cancer Care Northwest-North - Holland, Spokane, Washington, United States

Evergreen Hematology & Oncology (Farwell), Spokane, Washington, United States

Northwest Cancer Specialists-136th Ave, Vancouver, Washington, United States

Northwest Cancer Specialists-134th St., Vancouver, Washington, United States

Yakima Valley Memorial Hospital - North Star Lodge, Yakima, Washington, United States

Raleigh Regional Cancer Center, Beckley, West Virginia, United States

CAMC Health Education & Research Institute, Inc., Charleston, West Virginia, United States

West Virginia University Hospitals Inc., Morgantown, West Virginia, United States

Camden-Clark Memorial Hospital, Parkersburg, West Virginia, United States

Wheeling Hospital, Wheeling, West Virginia, United States

Marshfield Clinic Chippewa Falls Center, Chippewa Falls, Wisconsin, United States

Marshfield Clinic Regional CA Cntr - Sacred Heart Hospital, Eau Claire, Wisconsin, United States

CCOP, St. Vincent Hospital, Green Bay, Wisconsin, United States

CCOP, St. Mary's Hospital Medical Center, Green Bay, Wisconsin, United States

CCOP - Marshfield Clinic Research Foundation, Marshfield, Wisconsin, United States

Aurora Sinai Medical Center, Milwaukee, Wisconsin, United States

Froedtert Hospital, Milwaukee, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Marshfield Clinic Minocqua Center, Minocqua, Wisconsin, United States

Vince Lombardi Cancer Clinic - Oshkosh, Oshkosh, Wisconsin, United States

Marshfield Clinic at James Beck Cancer Center, Rhinelander, Wisconsin, United States

Marshfield Clinic Rice Lake Center, Rice Lake, Wisconsin, United States

Marshfield Clinic Cancer Care at St. Michael's Hospital, Stevens Point, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Aurora Women's Pavilion of Aurora West Allis Medical Center, West Allis, Wisconsin, United States

CCOP Marshfield Clinic - Weston Center, Weston, Wisconsin, United States

Marshfield Clinic Wisconsin Rapids Center, Wisconsin Rapids, Wisconsin, United States

Bon Secours Hospital, Cork, CK, Ireland

Letterkenny General Hospital, Letterkenny, DL, Ireland

Mater Private Hospital, Dublin, DN, Ireland

Beaumont Hospital, Dublin, , Ireland

St. Vincent's University Hospital, Dublin, , Ireland

Mater Misericordiae, Dublin, , Ireland

St James' Hospital, Dublin, , Ireland

St. James' Hospital, Dublin, , Ireland

University College Hospital, Galway, , Ireland

Sligo General Hospital, Sligo, , Ireland

Waterford Regional Hospital, Waterford, , Ireland

Contact Details

Name: Norman Wolmark, MD

Affiliation: NSABP Foundation Inc

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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