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Spots Global Cancer Trial Database for Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Higher Per Daily Treatment-Dose Radiation Therapy or Standard Per Daily Treatment Radiation Therapy in Treating Patients With Early-Stage Breast Cancer That Was Removed by Surgery

Official Title: A Phase III Trial of Accelerated Whole Breast Irradiation With Hypofractionation Plus Concurrent Boost Versus Standard Whole Breast Irradiation Plus Sequential Boost for Early-Stage Breast Cancer

Study ID: NCT01349322

Conditions

Breast Cancer

Study Description

Brief Summary: RATIONALE: It is not yet know whether higher per daily radiation therapy is equally as effective as standard per daily radiation therapy in treating breast cancer. PURPOSE: This randomized phase III trial studies how well an accelerated course of higher per daily radiation therapy with concomitant boost works compared to standard per daily radiation therapy with a sequential boost in treating patients with early-stage breast cancer that was removed by surgery.

Detailed Description: OBJECTIVES: Primary * To determine whether an accelerated course of hypofractionated whole-breast irradiation (WBI) including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be non-inferior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients. Secondary * To determine whether breast-related symptoms and cosmesis from accelerated WBI that is hypofractionated (in only 3 weeks) with a concomitant boost is non-inferior to standard WBI with sequential boost. * To determine whether the risk of late cardiac toxicity in patients with left-sided breast cancer treated with hypofractionation will be non-inferior to conventional fractionated radiation therapy (RT) based upon analysis of radiation dosimetry from CT-based treatment planning and normal tissue complication probability (NTCP) calculations. * To determine whether CT-based conformal methods intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) for WBI are feasible in a multi-institutional setting following lumpectomy in early-stage breast cancer patients and whether dose-volume analyses can be established to assess treatment adequacy and likelihood of toxicity. * To determine that cosmetic results and breast-related symptoms 3 years after hypofractionated breast radiation with concomitant boost will not be inferior to that obtained 3 years after WBI with sequential boost. * To determine whether future correlative studies can identify individual gene expressions and biological host factors associated with toxicity and/or local recurrence from standard and hypofractionated WBI. * If shown to be non-inferior, to then determine if accelerated course of hypofractionated WBI including a concomitant boost to the tumor bed in 15 fractions following lumpectomy will prove to be superior in local control to a regimen of standard WBI with a sequential boost following lumpectomy for early-stage breast cancer patients. * To determine whether treatment costs for hypofractionated WBI with concomitant boost are not higher than WBI with sequential boost. OUTLINE: This is a multicenter study. Patients are stratified according to age (\< 50 vs. ≥ 50 years), prior chemotherapy (yes vs. no), estrogen-receptor status (+ vs. -), and histology grade (1-2 vs. 3). Patients are randomized to 1 of 2 treatment arms. Treatment begins within 9 weeks of last surgery or chemotherapy delivery. After completion of study therapy, patients are followed at 1 month, at 6 months, and then yearly.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama at Birmingham Cancer Center, Birmingham, Alabama, United States

The Kirklin Clinic at Acton Road, Birmingham, Alabama, United States

21st Century Oncology-Scottsdale, Scottsdale, Arizona, United States

Mayo Clinic in Arizona, Scottsdale, Arizona, United States

Arizona Oncology Associates-West Orange Grove, Tucson, Arizona, United States

Banner University Medical Center - Tucson, Tucson, Arizona, United States

CHI Saint Vincent Cancer Center Hot Springs, Hot Springs, Arkansas, United States

University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States

Sutter Cancer Centers Radiation Oncology Services-Auburn, Auburn, California, United States

Sutter Cancer Centers Radiation Oncology Services-Cameron Park, Cameron Park, California, United States

Mercy San Juan Medical Center, Carmichael, California, United States

Enloe Medical Center, Chico, California, United States

City of Hope Comprehensive Cancer Center, Duarte, California, United States

Epic Care-Dublin, Dublin, California, United States

21st Century Oncology - El Segundo, El Segundo, California, United States

UC San Diego Moores Cancer Center, La Jolla, California, United States

Los Angeles County-USC Medical Center, Los Angeles, California, United States

USC / Norris Comprehensive Cancer Center, Los Angeles, California, United States

Cedars Sinai Medical Center, Los Angeles, California, United States

UCLA / Jonsson Comprehensive Cancer Center, Los Angeles, California, United States

Kaiser Permanente Oakland-Broadway, Oakland, California, United States

Kaiser Permanente-Rancho Cordova Cancer Center, Rancho Cordova, California, United States

Rohnert Park Cancer Center, Rohnert Park, California, United States

Sutter Cancer Centers Radiation Oncology Services-Roseville, Roseville, California, United States

The Permanente Medical Group-Roseville Radiation Oncology, Roseville, California, United States

Sutter Medical Center Sacramento, Sacramento, California, United States

University of California Davis Comprehensive Cancer Center, Sacramento, California, United States

South Sacramento Cancer Center, Sacramento, California, United States

Santa Clara Valley Medical Center, San Jose, California, United States

Kaiser Permanente Medical Center - Santa Clara, Santa Clara, California, United States

City of Hope South Pasadena, South Pasadena, California, United States

Kaiser Permanente Cancer Treatment Center, South San Francisco, California, United States

Sutter Cancer Centers Radiation Oncology Services-Vacaville, Vacaville, California, United States

University of Colorado Hospital, Aurora, Colorado, United States

Penrose-Saint Francis Healthcare, Colorado Springs, Colorado, United States

Porter Adventist Hospital, Denver, Colorado, United States

Shaw Cancer Center, Edwards, Colorado, United States

McKee Medical Center, Loveland, Colorado, United States

Hartford Hospital, Hartford, Connecticut, United States

MedStar Washington Hospital Center, Washington, District of Columbia, United States

John Fitzgerald Kennedy Medical Center, Atlantis, Florida, United States

Florida Hospital Memorial Medical Center, Daytona Beach, Florida, United States

UM Sylvester Comprehensive Cancer Center at Deerfield Beach, Deerfield Beach, Florida, United States

21st Century Oncology - Fort Walton Beach, Fort Walton Beach, Florida, United States

University of Florida Health Science Center - Gainesville, Gainesville, Florida, United States

Integrated Community Oncology Network-Florida Cancer Center Beaches, Jacksonville Beach, Florida, United States

Baptist MD Anderson Cancer Center, Jacksonville, Florida, United States

Integrated Community Oncology Network-Southside Cancer Center, Jacksonville, Florida, United States

University of Florida Health Science Center - Jacksonville, Jacksonville, Florida, United States

Mayo Clinic in Florida, Jacksonville, Florida, United States

Baptist Medical Center South, Jacksonville, Florida, United States

Jackson Memorial Hospital-Holtz Children's Hospital, Miami, Florida, United States

University of Miami Miller School of Medicine-Sylvester Cancer Center, Miami, Florida, United States

21st Century Oncology-Orange Park, Orange Park, Florida, United States

AdventHealth Orlando, Orlando, Florida, United States

Orlando Health Cancer Institute, Orlando, Florida, United States

Cancer Center of Putnam, Palatka, Florida, United States

Integrated Community Oncology Network-Flager Cancer Center, Saint Augustine, Florida, United States

Moffitt Cancer Center, Tampa, Florida, United States

The Villages Regional Hospital, The Villages, Florida, United States

Grady Health System, Atlanta, Georgia, United States

Emory University Hospital Midtown, Atlanta, Georgia, United States

Piedmont Hospital, Atlanta, Georgia, United States

Emory University Hospital/Winship Cancer Institute, Atlanta, Georgia, United States

Emory Saint Joseph's Hospital, Atlanta, Georgia, United States

Northside Hospital, Atlanta, Georgia, United States

Northside Hospital-Forsyth, Cumming, Georgia, United States

Memorial Health University Medical Center, Savannah, Georgia, United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler, Savannah, Georgia, United States

Queen's Medical Center, Honolulu, Hawaii, United States

Saint Alphonsus Cancer Care Center-Boise, Boise, Idaho, United States

Rush - Copley Medical Center, Aurora, Illinois, United States

Northwestern University, Chicago, Illinois, United States

University of Chicago Comprehensive Cancer Center, Chicago, Illinois, United States

Advocate Illinois Masonic Medical Center, Chicago, Illinois, United States

Decatur Memorial Hospital, Decatur, Illinois, United States

Freeport Memorial Hospital/Leonard C Ferguson Cancer Center, Freeport, Illinois, United States

Loyola University Medical Center, Maywood, Illinois, United States

UC Comprehensive Cancer Center at Silver Cross, New Lenox, Illinois, United States

Carle Cancer Institute Normal, Normal, Illinois, United States

Advocate Lutheran General Hospital, Park Ridge, Illinois, United States

OSF Saint Francis Radiation Oncology at Peoria Cancer Center, Peoria, Illinois, United States

OSF Saint Francis Medical Center, Peoria, Illinois, United States

Swedish American Hospital, Rockford, Illinois, United States

SwedishAmerican Regional Cancer Center/ACT, Rockford, Illinois, United States

Saint John's Hospital, Springfield, Illinois, United States

Carle Cancer Center, Urbana, Illinois, United States

Northwestern Medicine Cancer Center Warrenville, Warrenville, Illinois, United States

Saint Vincent Anderson Regional Hospital/Cancer Center, Anderson, Indiana, United States

IU Health West Hospital, Avon, Indiana, United States

Goshen Center for Cancer Care, Goshen, Indiana, United States

Indiana University/Melvin and Bren Simon Cancer Center, Indianapolis, Indiana, United States

IU Health Methodist Hospital, Indianapolis, Indiana, United States

Community Cancer Center East, Indianapolis, Indiana, United States

Community Cancer Center North, Indianapolis, Indiana, United States

Michiana Hematology Oncology PC-Mishawaka, Mishawaka, Indiana, United States

IU Health Ball Memorial Hospital, Muncie, Indiana, United States

Mercy Cancer Center-West Lakes, Clive, Iowa, United States

Iowa Methodist Medical Center, Des Moines, Iowa, United States

Mercy Medical Center - Des Moines, Des Moines, Iowa, United States

Finley Hospital, Dubuque, Iowa, United States

University of Kansas Cancer Center, Kansas City, Kansas, United States

Lawrence Memorial Hospital, Lawrence, Kansas, United States

University of Kansas Cancer Center-Overland Park, Overland Park, Kansas, United States

Kansas City NCI Community Oncology Research Program, Prairie Village, Kansas, United States

Cotton O'Neil Cancer Center / Stormont Vail Health, Topeka, Kansas, United States

Ascension Via Christi Hospitals Wichita, Wichita, Kansas, United States

Wichita NCI Community Oncology Research Program, Wichita, Kansas, United States

University of Kentucky/Markey Cancer Center, Lexington, Kentucky, United States

Owensboro Health Mitchell Memorial Cancer Center, Owensboro, Kentucky, United States

Tulane University Health Sciences Center, New Orleans, Louisiana, United States

Anne Arundel Medical Center, Annapolis, Maryland, United States

University of Maryland/Greenebaum Cancer Center, Baltimore, Maryland, United States

Greater Baltimore Medical Center, Baltimore, Maryland, United States

Saint Agnes Hospital, Baltimore, Maryland, United States

Walter Reed National Military Medical Center, Bethesda, Maryland, United States

Central Maryland Radiation Oncology in Howard County, Columbia, Maryland, United States

UM Baltimore Washington Medical Center/Tate Cancer Center, Glen Burnie, Maryland, United States

TidalHealth Peninsula Regional, Salisbury, Maryland, United States

Massachusetts General Hospital Cancer Center, Boston, Massachusetts, United States

Boston Medical Center, Boston, Massachusetts, United States

Mass General/North Shore Cancer Center, Danvers, Massachusetts, United States

Lowell General Hospital, Lowell, Massachusetts, United States

Newton-Wellesley Hospital, Newton, Massachusetts, United States

University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan, United States

GenesisCare USA - Clarkston, Clarkston, Michigan, United States

Henry Ford Macomb Hospital-Clinton Township, Clinton Township, Michigan, United States

Wayne State University/Karmanos Cancer Institute, Detroit, Michigan, United States

Henry Ford Hospital, Detroit, Michigan, United States

Ascension Saint John Hospital, Detroit, Michigan, United States

GenesisCare USA - Farmington Hills, Farmington Hills, Michigan, United States

Weisberg Cancer Treatment Center, Farmington Hills, Michigan, United States

Beaumont Hospital - Farmington Hills, Farmington Hills, Michigan, United States

McLaren Cancer Institute-Flint, Flint, Michigan, United States

Mercy Health Saint Mary's, Grand Rapids, Michigan, United States

Spectrum Health at Butterworth Campus, Grand Rapids, Michigan, United States

West Michigan Cancer Center, Kalamazoo, Michigan, United States

KCC Radiation Oncology at Monroe Cancer Center, Monroe, Michigan, United States

McLaren Cancer Institute-Northern Michigan, Petoskey, Michigan, United States

Saint Joseph Mercy Oakland, Pontiac, Michigan, United States

William Beaumont Hospital-Royal Oak, Royal Oak, Michigan, United States

Ascension Providence Hospitals - Southfield, Southfield, Michigan, United States

William Beaumont Hospital - Troy, Troy, Michigan, United States

GenesisCare USA - Troy, Troy, Michigan, United States

Saint John Macomb-Oakland Hospital, Warren, Michigan, United States

Mayo Clinic Health System in Albert Lea, Albert Lea, Minnesota, United States

Sanford Joe Lueken Cancer Center, Bemidji, Minnesota, United States

Miller-Dwan Hospital, Duluth, Minnesota, United States

Mayo Clinic Health Systems-Mankato, Mankato, Minnesota, United States

Mayo Clinic in Rochester, Rochester, Minnesota, United States

Coborn Cancer Center at Saint Cloud Hospital, Saint Cloud, Minnesota, United States

Singing River Hospital, Pascagoula, Mississippi, United States

Saint Francis Medical Center, Cape Girardeau, Missouri, United States

Saint Luke's Hospital, Chesterfield, Missouri, United States

Siteman Cancer Center at West County Hospital, Creve Coeur, Missouri, United States

The University of Kansas Cancer Center-South, Kansas City, Missouri, United States

University of Kansas Cancer Center - North, Kansas City, Missouri, United States

University of Kansas Cancer Center - Lee's Summit, Lee's Summit, Missouri, United States

Liberty Radiation Oncology Center, Liberty, Missouri, United States

Washington University School of Medicine, Saint Louis, Missouri, United States

Siteman Cancer Center-South County, Saint Louis, Missouri, United States

Siteman Cancer Center at Saint Peters Hospital, Saint Peters, Missouri, United States

Billings Clinic Cancer Center, Billings, Montana, United States

Benefis Healthcare- Sletten Cancer Institute, Great Falls, Montana, United States

Kalispell Regional Medical Center, Kalispell, Montana, United States

Nebraska Methodist Hospital, Omaha, Nebraska, United States

University of Nebraska Medical Center, Omaha, Nebraska, United States

Radiation Oncology Centers of Nevada Central, Las Vegas, Nevada, United States

Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States

Renown Regional Medical Center, Reno, Nevada, United States

Saint Mary's Regional Medical Center, Reno, Nevada, United States

Dartmouth Hitchcock Medical Center, Lebanon, New Hampshire, United States

Memorial Sloan Kettering Basking Ridge, Basking Ridge, New Jersey, United States

Ocean Medical Center, Brick, New Jersey, United States

Monmouth Medical Center, Long Branch, New Jersey, United States

Morristown Medical Center, Morristown, New Jersey, United States

Virtua Memorial, Mount Holly, New Jersey, United States

Jersey Shore Medical Center, Neptune, New Jersey, United States

Saint Peter's University Hospital, New Brunswick, New Jersey, United States

Capital Health Medical Center-Hopewell, Pennington, New Jersey, United States

Riverview Medical Center/Booker Cancer Center, Red Bank, New Jersey, United States

Sparta Cancer Treatment Center, Sparta, New Jersey, United States

Overlook Hospital, Summit, New Jersey, United States

Community Medical Center, Toms River, New Jersey, United States

Virtua Voorhees, Voorhees, New Jersey, United States

University of New Mexico Cancer Center, Albuquerque, New Mexico, United States

Memorial Medical Center - Las Cruces, Las Cruces, New Mexico, United States

New York Oncology Hematology PC - Albany, Albany, New York, United States

Saint Peter's Health Partners, Albany, New York, United States

Montefiore Medical Center - Moses Campus, Bronx, New York, United States

Roswell Park Cancer Institute, Buffalo, New York, United States

Sands Cancer Center, Canandaigua, New York, United States

Memorial Sloan Kettering Commack, Commack, New York, United States

Mary Imogene Bassett Hospital, Cooperstown, New York, United States

Hematology Oncology Associates of Central New York-East Syracuse, East Syracuse, New York, United States

Cayuga Medical Center, Ithaca, New York, United States

Northwell Health NCORP, Lake Success, New York, United States

Northwell Health/Center for Advanced Medicine, Lake Success, New York, United States

Long Island Jewish Medical Center, New Hyde Park, New York, United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center, New York, New York, United States

Memorial Sloan Kettering Cancer Center, New York, New York, United States

Hudson Valley Oncology Associates, Poughkeepsie, New York, United States

Wilmot Cancer Institute Radiation Oncology at Greece, Rochester, New York, United States

Highland Hospital, Rochester, New York, United States

Rochester General Hospital, Rochester, New York, United States

University of Rochester, Rochester, New York, United States

Memorial Sloan Kettering Sleepy Hollow, Sleepy Hollow, New York, United States

Staten Island University Hospital, Staten Island, New York, United States

Stony Brook University Medical Center, Stony Brook, New York, United States

Memorial Sloan Kettering Nassau, Uniondale, New York, United States

Dickstein Cancer Treatment Center, White Plains, New York, United States

Duke University Medical Center, Durham, North Carolina, United States

East Carolina University, Greenville, North Carolina, United States

The Coleman Radiation Center-Carteret General Hospital, Morehead City, North Carolina, United States

CarolinaEast Medical Center, New Bern, North Carolina, United States

FirstHealth of the Carolinas-Moore Regional Hospital, Pinehurst, North Carolina, United States

Iredell Memorial Hospital, Statesville, North Carolina, United States

NHRMC Radiation Oncology - Supply, Supply, North Carolina, United States

New Hanover Regional Medical Center/Zimmer Cancer Center, Wilmington, North Carolina, United States

NHRMC Radiation Oncology - 16th Street, Wilmington, North Carolina, United States

Sanford Bismarck Medical Center, Bismarck, North Dakota, United States

Sanford Roger Maris Cancer Center, Fargo, North Dakota, United States

Altru Cancer Center, Grand Forks, North Dakota, United States

Summa Health System - Akron Campus, Akron, Ohio, United States

Cleveland Clinic Akron General, Akron, Ohio, United States

Summa Health System - Barberton Campus, Barberton, Ohio, United States

UHHS-Chagrin Highlands Medical Center, Beachwood, Ohio, United States

Geauga Hospital, Chardon, Ohio, United States

Adena Regional Medical Center, Chillicothe, Ohio, United States

The Christ Hospital, Cincinnati, Ohio, United States

University of Cincinnati Cancer Center-UC Medical Center, Cincinnati, Ohio, United States

Case Western Reserve University, Cleveland, Ohio, United States

Cleveland Clinic Cancer Center/Fairview Hospital, Cleveland, Ohio, United States

Cleveland Clinic Foundation, Cleveland, Ohio, United States

Ohio State University Comprehensive Cancer Center, Columbus, Ohio, United States

Cleveland Clinic Cancer Center Independence, Independence, Ohio, United States

Hillcrest Hospital Cancer Center, Mayfield Heights, Ohio, United States

Summa Health Medina Medical Center, Medina, Ohio, United States

UH Seidman Cancer Center at Lake Health Mentor Campus, Mentor, Ohio, United States

UH Seidman Cancer Center at Southwest General Hospital, Middleburg Heights, Ohio, United States

University Hospitals Parma Medical Center, Parma, Ohio, United States

University Hospitals Portage Medical Center, Ravenna, Ohio, United States

North Coast Cancer Care, Sandusky, Ohio, United States

Cleveland Clinic Cancer Center Strongsville, Strongsville, Ohio, United States

UHHS-Westlake Medical Center, Westlake, Ohio, United States

Cleveland Clinic Wooster Family Health and Surgery Center, Wooster, Ohio, United States

University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, United States

Natalie Warren Bryant Cancer Center at Saint Francis, Tulsa, Oklahoma, United States

Clackamas Radiation Oncology Center, Clackamas, Oregon, United States

Willamette Valley Cancer Center, Eugene, Oregon, United States

Three Rivers Community Hospital, Grants Pass, Oregon, United States

Providence Medford Medical Center, Medford, Oregon, United States

Rogue Valley Medical Center, Medford, Oregon, United States

Providence Portland Medical Center, Portland, Oregon, United States

Jefferson Abington Hospital, Abington, Pennsylvania, United States

UPMC-Heritage Valley Health System Beaver, Beaver, Pennsylvania, United States

Bryn Mawr Hospital, Bryn Mawr, Pennsylvania, United States

Geisinger Medical Center, Danville, Pennsylvania, United States

Delaware County Memorial Hospital, Drexel Hill, Pennsylvania, United States

Northeast Radiation Oncology Center, Dunmore, Pennsylvania, United States

Pocono Medical Center, East Stroudsburg, Pennsylvania, United States

UPMC Hillman Cancer Center Erie, Erie, Pennsylvania, United States

Fox Chase Cancer Center Buckingham, Furlong, Pennsylvania, United States

Adams Cancer Center, Gettysburg, Pennsylvania, United States

UPMC Cancer Centers - Arnold Palmer Pavilion, Greensburg, Pennsylvania, United States

Cherry Tree Cancer Center, Hanover, Pennsylvania, United States

Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, United States

UPMC-Johnstown/John P. Murtha Regional Cancer Center, Johnstown, Pennsylvania, United States

Lancaster General Hospital, Lancaster, Pennsylvania, United States

Saint Mary Medical and Regional Cancer Center, Langhorne, Pennsylvania, United States

UPMC Cancer Center at UPMC McKeesport, McKeesport, Pennsylvania, United States

Holy Redeemer Hospital and Medical Center, Meadowbrook, Pennsylvania, United States

Riddle Memorial Hospital, Media, Pennsylvania, United States

Intercommunity Cancer Center, Monroeville, Pennsylvania, United States

UPMC-Coraopolis/Heritage Valley Radiation Oncology, Moon, Pennsylvania, United States

Allegheny Valley Hospital, Natrona Heights, Pennsylvania, United States

UPMC Jameson, New Castle, Pennsylvania, United States

Paoli Memorial Hospital, Paoli, Pennsylvania, United States

University of Pennsylvania/Abramson Cancer Center, Philadelphia, Pennsylvania, United States

Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, United States

Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States

Allegheny General Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Magee Womens Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Saint Margaret, Pittsburgh, Pennsylvania, United States

UPMC-Shadyside Hospital, Pittsburgh, Pennsylvania, United States

UPMC Jefferson Regional Radiation Oncology, Pittsburgh, Pennsylvania, United States

UPMC-Passavant Hospital, Pittsburgh, Pennsylvania, United States

UPMC-Saint Clair Hospital Cancer Center, Pittsburgh, Pennsylvania, United States

Penn State Health Saint Joseph Medical Center, Reading, Pennsylvania, United States

Grand View Hospital, Sellersville, Pennsylvania, United States

Mount Nittany Medical Center, State College, Pennsylvania, United States

Crozer-Chester Medical Center, Upland, Pennsylvania, United States

UPMC Washington Hospital Radiation Oncology, Washington, Pennsylvania, United States

Reading Hospital, West Reading, Pennsylvania, United States

Lankenau Medical Center, Wynnewood, Pennsylvania, United States

WellSpan Health-York Hospital, York, Pennsylvania, United States

Prisma Health Cancer Institute - Spartanburg, Boiling Springs, South Carolina, United States

Medical University of South Carolina, Charleston, South Carolina, United States

Greenville Health System Cancer Institute-Andrews, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Faris, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Eastside, Greenville, South Carolina, United States

Prisma Health Cancer Institute - Greer, Greer, South Carolina, United States

Gibbs Cancer Center-Pelham, Greer, South Carolina, United States

The Radiation Oncology Center-Hilton Head/Bluffton, Hilton Head Island, South Carolina, United States

Prisma Health Cancer Institute - Seneca, Seneca, South Carolina, United States

Spartanburg Medical Center, Spartanburg, South Carolina, United States

Lexington Medical Center, West Columbia, South Carolina, United States

Rapid City Regional Hospital, Rapid City, South Dakota, United States

Avera Cancer Institute, Sioux Falls, South Dakota, United States

Texas Oncology-Arlington South, Arlington, Texas, United States

Texas Oncology-Austin Midtown, Austin, Texas, United States

Texas Oncology - South Austin Cancer Center, Austin, Texas, United States

Texas Oncology Bedford, Bedford, Texas, United States

UT Southwestern/Simmons Cancer Center-Dallas, Dallas, Texas, United States

Texas Oncology - Denison Cancer Center, Denison, Texas, United States

Texas Oncology-Denton South, Denton, Texas, United States

Brooke Army Medical Center, Fort Sam Houston, Texas, United States

Texas Oncology - Fort Worth Cancer Center, Fort Worth, Texas, United States

Memorial Hermann Memorial City Medical Center, Houston, Texas, United States

Baylor Medical Center at Irving, Irving, Texas, United States

Texas Oncology - Lewisville, Lewisville, Texas, United States

West Texas Cancer Center, Odessa, Texas, United States

Texas Oncology-Plano West, Plano, Texas, United States

Texas Oncology-Seton Williamson, Round Rock, Texas, United States

Texas Oncology - Round Rock Cancer Center, Round Rock, Texas, United States

Cancer Care Centers of South Texas- Northeast, San Antonio, Texas, United States

University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States

Texas Oncology Cancer Center Sugar Land, Sugar Land, Texas, United States

Texas Oncology-Wichita Falls Texoma Cancer Center, Wichita Falls, Texas, United States

Logan Regional Hospital, Logan, Utah, United States

Intermountain Medical Center, Murray, Utah, United States

McKay-Dee Hospital Center, Ogden, Utah, United States

Dixie Medical Center Regional Cancer Center, Saint George, Utah, United States

Utah Cancer Specialists-Salt Lake City, Salt Lake City, Utah, United States

Huntsman Cancer Institute/University of Utah, Salt Lake City, Utah, United States

Norris Cotton Cancer Center-North, Saint Johnsbury, Vermont, United States

Inova Alexandria Hospital, Alexandria, Virginia, United States

University of Virginia Cancer Center, Charlottesville, Virginia, United States

Inova Fairfax Hospital, Falls Church, Virginia, United States

Augusta Health Center for Cancer and Blood Disorders, Fishersville, Virginia, United States

Sentara Cancer Institute at Sentara CarePlex Hospital, Hampton, Virginia, United States

Sentara Rockingham Memorial Hospital Hahn Cancer Center, Harrisonburg, Virginia, United States

Sentara Norfolk General Hospital, Norfolk, Virginia, United States

Naval Medical Center - Portsmouth, Portsmouth, Virginia, United States

Virginia Commonwealth University/Massey Cancer Center, Richmond, Virginia, United States

Sentara Virginia Beach General Hospital, Virginia Beach, Virginia, United States

Harrison Medical Center, Bremerton, Washington, United States

Saint Francis Hospital, Federal Way, Washington, United States

Tri-Cities Cancer Center, Kennewick, Washington, United States

Skagit Valley Hospital, Mount Vernon, Washington, United States

Virginia Mason Medical Center, Seattle, Washington, United States

Seattle Cancer Care Alliance, Seattle, Washington, United States

Olympic Medical Cancer Care Center, Sequim, Washington, United States

Cancer Care Northwest - Spokane South, Spokane, Washington, United States

Cancer Care Northwest-North Spokane, Spokane, Washington, United States

Wenatchee Valley Hospital and Clinics, Wenatchee, Washington, United States

Edwards Comprehensive Cancer Center, Huntington, West Virginia, United States

West Virginia University Healthcare, Morgantown, West Virginia, United States

Wheeling Hospital/Schiffler Cancer Center, Wheeling, West Virginia, United States

Langlade Hospital and Cancer Center, Antigo, Wisconsin, United States

ThedaCare Regional Medical Center - Appleton, Appleton, Wisconsin, United States

Beloit Memorial Hospital, Beloit, Wisconsin, United States

Mayo Clinic Health System Eau Claire Hospital-Luther Campus, Eau Claire, Wisconsin, United States

Saint Agnes Hospital/Agnesian Cancer Center, Fond Du Lac, Wisconsin, United States

Bellin Memorial Hospital, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center Green Bay, Green Bay, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Saint Mary's, Green Bay, Wisconsin, United States

Aurora BayCare Medical Center, Green Bay, Wisconsin, United States

UW Cancer Center Johnson Creek, Johnson Creek, Wisconsin, United States

Gundersen Lutheran Medical Center, La Crosse, Wisconsin, United States

Mayo Clinic Health System-Franciscan Healthcare, La Crosse, Wisconsin, United States

University of Wisconsin Hospital and Clinics, Madison, Wisconsin, United States

Bay Area Medical Center, Marinette, Wisconsin, United States

Froedtert Menomonee Falls Hospital, Menomonee Falls, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital Ozaukee, Mequon, Wisconsin, United States

Ascension Columbia Saint Mary's Hospital - Milwaukee, Milwaukee, Wisconsin, United States

Aurora Saint Luke's Medical Center, Milwaukee, Wisconsin, United States

Medical College of Wisconsin, Milwaukee, Wisconsin, United States

Ascension All Saints Hospital, Racine, Wisconsin, United States

Vince Lombardi Cancer Clinic-Sheboygan, Sheboygan, Wisconsin, United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Aurora Medical Center in Summit, Summit, Wisconsin, United States

Vince Lombardi Cancer Clinic-Two Rivers, Two Rivers, Wisconsin, United States

ProHealth Waukesha Memorial Hospital, Waukesha, Wisconsin, United States

Aspirus Regional Cancer Center, Wausau, Wisconsin, United States

Aurora West Allis Medical Center, West Allis, Wisconsin, United States

Cross Cancer Institute, Edmonton, Alberta, Canada

BCCA-Vancouver Cancer Centre, Vancouver, British Columbia, Canada

CancerCare Manitoba, Winnipeg, Manitoba, Canada

Atlantic Health Sciences Corporation-Saint John Regional Hospital, Saint John, New Brunswick, Canada

Grand River Regional Cancer Centre at Grand River Hospital, Kitchener, Ontario, Canada

London Regional Cancer Program, London, Ontario, Canada

Stronach Regional Health Centre at Southlake, Newmarket, Ontario, Canada

Ottawa Hospital and Cancer Center-General Campus, Ottawa, Ontario, Canada

Ottawa Hospital-Civic Campus, Ottawa, Ontario, Canada

Irving Greenberg Family Cancer Centre, Ottawa, Ontario, Canada

Windsor Regional Cancer Centre, Windsor, Ontario, Canada

Hopital de la Cite-de-la-Sante, Laval, Quebec, Canada

CIUSSSEMTL-Hopital Maisonneuve-Rosemont, Montreal, Quebec, Canada

CHUM - Hopital Notre-Dame, Montreal, Quebec, Canada

McGill University Department of Oncology, Montreal, Quebec, Canada

CHUM - Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada

The Research Institute of the McGill University Health Centre (MUHC), Montreal, Quebec, Canada

CHU de Quebec-L'Hotel-Dieu de Quebec (HDQ), Quebec City, Quebec, Canada

Centre Hospitalier Universitaire de Sherbrooke-Fleurimont, Sherbrooke, Quebec, Canada

Allan Blair Cancer Centre, Regina, Saskatchewan, Canada

Pamela Youde Nethersole Eastern Hospital, Chai Wan, , Hong Kong

Rabin Medical Center, Petach Tikva, , Israel

Chaim Sheba Medical Center, Tel Hashomer, , Israel

Shizuoka Cancer Center, Shizuoka City, Suntou, Japan

National Cancer Center-Korea, Goyang-si, Gyeonggi-do, Korea, Republic of

Yonsei University Health System-Severance Hospital, Seoul, , Korea, Republic of

National University Hospital Singapore, Singapore, , Singapore

National Cancer Centre Singapore, Singapore, , Singapore

Kantonsspital Aarau, Aarau, , Switzerland

Contact Details

Name: Frank A. Vicini, MD, FACR

Affiliation: St. Joseph Mercy Oakland

Role: PRINCIPAL_INVESTIGATOR

Name: Gary M. Freedman, MD

Affiliation: University of Pennsylvania

Role: STUDY_CHAIR

Name: Julia R. White, MD

Affiliation: Ohio State University

Role: STUDY_CHAIR

Name: Douglas W. Arthur, MD

Affiliation: Virginia Commonwealth University

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

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