Spots Global Cancer Trial Database for Effect of Physical Exercise on Tumor Proliferation of Luminal B Breast Cancer Patients

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Trial Identification

Brief Title: Effect of Physical Exercise on Tumor Proliferation of Luminal B Breast Cancer Patients

Official Title: Effect of Physical Exercise on Ki-67 Levels in Women With Operable Breast Cancer Hormonal Receptor Positive, HER2 Negative

Study ID: NCT03860740

Conditions

Breast Cancer

Luminal B

Interventions

Exercise

Stretching

Study Description

Brief Summary: Observational study to evaluate the effect of physical exercise prior to surgery and adjuvant systemic treatment in women with newly diagnosed operable hormone receptor(HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancers

Detailed Description: Effect of exercise on tumor aggressiveness and the impact on patients' quality of life. Exercise is a safe and effective treatment for women diagnosed with breast cancer (BC), that has an integral benefit during and after treatments, however, the effect at the tumour microenvironment it is unknown; previous studies have evaluated the association between exercise and BC, finding a positive influence on it, which suggest that exercise could reduce the aggressiveness of the tumour. This study will explore the exercise impact in tumor microenvironment, as part of the therapy given to the patients prior to surgery and treatment. In addition, different serum biomarkers involved and the tailoring of exercise for these women will be evaluated. The effect of exercise on treatments secondary effects, biomarkers and quality of life will be evaluated after 6 months of BC surgery. This project will open a window of opportunity to explore new translational research as well as new treatment vias to the patients of this breast cancer subgroup.