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Spots Global Cancer Trial Database for Validation of 70-gene MammaPrint Profile in Japanese Population

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Validation of 70-gene MammaPrint Profile in Japanese Population

Official Title: Validation 70-gene MammaPrint Profile in Japanese Population

Study ID: NCT00904566

Conditions

Breast Cancer

Interventions

Study Description

Brief Summary: By using gene-expression profiling, Van't Veer and colleagues developed a 70-gene prognosis profile, MammaPrint, to identify breast cancer patients who are at low risk of developing distant metastases and therefore might safely be spared chemotherapy. The aim of this study is to evaluate the prognostic value of the 70-gene Mammaprint profile in Japanese women with node-negative breast cancer.

Detailed Description: Frozen tumor samples from 140 node-negative, breast cancer patients aged between 29 and 70 years at diagnosis are hybridized on MammaPrint array. Patients were treated with breast conserving therapy or mastectomy with axillary lymph node dissection between December 1998 and August 2001 at Osaka Medical Center for Cancer and Cardiovascular Diseases. Samples are evaluated by gene expression profiling for the 70-gene MammaPrint profile and classified as genomic high risk or genomic low risk.

Eligibility

Minimum Age: 29 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Osaka Medical Center for Cancer and Cadiovascular Diseases, Osaka, , Japan

Contact Details

Name: Kikuya Kato, MD, PhD, Prof

Affiliation: Osaka Medical Center for Cancer and Cardiovascular Diseases

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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