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Spots Global Cancer Trial Database for Identification of Genes Associated With Cancer in Patients and Siblings Who Have Cancer

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Trial Identification

Brief Title: Identification of Genes Associated With Cancer in Patients and Siblings Who Have Cancer

Official Title: ECOG Laboratory Study: Mapping Interactive Cancer Susceptibility Loci

Study ID: NCT00003329

Interventions

gene mapping

Study Description

Brief Summary: RATIONALE: Identification of genes that may be associated with developing certain types of cancer may someday provide important information about a person's risk of getting cancer. PURPOSE: This clinical trial is studying to see if certain genes may be associated with cancer in patients with cancer of the breast, prostate, lung, or colon and siblings of these patients.

Detailed Description: OBJECTIVES: * Gather allele-sharing statistics at approximately 100 candidate loci throughout the human genome most likely to influence genetic risk of cancer. * Use these allele-sharing statistics to test the interaction of each locus individually with cancer-associated, rare alleles of HRAS1. * Generalize this approach for one of four cancers (breast, colon, lung, or prostate), using allele-sharing statistics to test the interaction of each locus with every other locus. * Replicate positive results in a distinct set of sibling pairs with cancer. * Examine, when loci contributing to risk are detected, the influence of this genetic background on clinical outcomes, such as survival. OUTLINE: Each patient-sibling pair completes a family history questionnaire about the incidence of cancer in the family. Blood samples are obtained from both the patient and the sibling (and both living parents, if available). The blood samples are genotyped using approximately 300 micro-satellite markers flanking 100 candidate genes previously implicated in genetic risk for cancer. Certain loci are a priority due to their association with HRAS1: BRCA1 and all known mismatch repair loci; other repair genes, such as ATM; the Bloom's syndrome locus; and the XRCC group. Other genes are also mapped. Patients do not receive the results of the genetic testing and the results do not influence the type and duration of treatment. Patients only are followed annually. PROJECTED ACCRUAL: This study will accrue 1,000 patient-sibling pairs for breast cancer. After 18 months, another 1,000 patient-sibling pairs will be accrued for breast cancer. Therefore, up to 2,000 patient-sibling pairs will be accrued over 5 years. (Feasibility of accruing pairs for lung, colon, and prostate cancer is being assessed.)

Eligibility

Minimum Age: 0 Years

Eligible Ages: CHILD, ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Lucy Curci Cancer Center at Eisenhower Memorial Hospital and Medical Center, Rancho Mirage, California, United States

Front Range Cancer Specialists, Fort Collins, Colorado, United States

Eugene M. and Christine E. Lynn Cancer Institute at Boca Raton Community Hospital, Boca Raton, Florida, United States

Lakeland Regional Cancer Center at Lakeland Regional Medical Center, Lakeland, Florida, United States

Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago, Illinois, United States

Veterans Affairs Medical Center - Chicago Westside Hospital, Chicago, Illinois, United States

Evanston Northwestern Healthcare - Evanston Hospital, Evanston, Illinois, United States

Hematology Oncology Associates - Skokie, Skokie, Illinois, United States

Siouxland Hematology-Oncology Associates, LLP, Sioux City, Iowa, United States

Mercy Medical Center - Sioux City, Sioux City, Iowa, United States

St. Luke's Regional Medical Center, Sioux City, Iowa, United States

Green Bay Oncology, Limited - Escanaba, Escanaba, Michigan, United States

Dickinson County Healthcare System, Iron Mountain, Michigan, United States

University Medical Center of Southern Nevada, Las Vegas, Nevada, United States

CCOP - Nevada Cancer Research Foundation, Las Vegas, Nevada, United States

Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital Marlton, Marlton, New Jersey, United States

Cancer Institute of New Jersey at UMDNJ - Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States

Fox Chase Virtua Health Cancer Program at Virtua West Jersey, Voorhees, New Jersey, United States

Our Lady of Mercy Medical Center Comprehensive Cancer Center, Bronx, New York, United States

Finger Lakes Hematology and Oncology, Clifton Springs, New York, United States

Joan Karnell Cancer Center at Pennsylvania Hospital, Philadelphia, Pennsylvania, United States

UPMC Cancer Centers, Pittsburgh, Pennsylvania, United States

Jennersville Regional Hospital, West Grove, Pennsylvania, United States

Fox Valley Hematology and Oncology - East Grant Street, Appleton, Wisconsin, United States

Green Bay Oncology, Limited at St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States

Green Bay Oncology, Limited at St. Mary's Hospital, Green Bay, Wisconsin, United States

St. Mary's Hospital Medical Center - Green Bay, Green Bay, Wisconsin, United States

St. Vincent Hospital Regional Cancer Center, Green Bay, Wisconsin, United States

Bay Area Cancer Care Center at Bay Area Medical Center, Marinette, Wisconsin, United States

Green Bay Oncology, Limited - Oconto Falls, Oconto Falls, Wisconsin, United States

All Saints Cancer Center at Wheaton Franciscan Healthcare, Racine, Wisconsin, United States

Green Bay Oncology, Limited - Sturgeon Bay, Sturgeon Bay, Wisconsin, United States

Contact Details

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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