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Brief Title: A Study of Avastin (Bevacizumab) Plus Taxane-Based Therapy in Patients With Locally Recurrent or Metastatic Breast Cancer.
Official Title: An Open-label Study to Evaluate the Safety and Effect on Disease Progression and Overall Survival of Avastin Plus Taxane-based Chemotherapy in Patients With Locally Recurrent or Metastatic Breast Cancer
Study ID: NCT00448591
Brief Summary: This single arm study will assess the safety and efficacy of a regimen of Avastin plus a taxane, with or without additional chemotherapy, as first-line treatment in patients with locally recurrent or metastatic breast cancer. All patients will receive Avastin (10mg/kg iv every 2 weeks, or 15 mg/kg iv every 3 weeks) plus taxane-based chemotherapy. If taxanes are contraindicated, alternative chemotherapy (other than anthracyclines or pegylated liposomal doxorubicin) may be used. The anticipated time on study treatment is until disease progression, and the target sample size is 500+ individuals.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, Buenos Aires, , Argentina
, Buenos Aires, , Argentina
, La Plata, , Argentina
, Rosario, , Argentina
, Tucuman, , Argentina
, Adelaide, , Australia
, Darlinghurst, , Australia
, East Melbourne, , Australia
, Frankston, , Australia
, Gosford, , Australia
, Lismore, , Australia
, Maroochydore, , Australia
, Milton, , Australia
, Perth, , Australia
, Richmond, , Australia
, St. Leonards, , Australia
, Sydney, , Australia
, Sydney, , Australia
, Wodonga, , Australia
, Bludesch, , Austria
, Bregenz, , Austria
, Dornbirn, , Austria
, Graz, , Austria
, Hall in Tirol, , Austria
, Innsbruck, , Austria
, Klagenfurt, , Austria
, Krems, , Austria
, Kufstein, , Austria
, Leoben, , Austria
, Linz, , Austria
, Ried-innkreis, , Austria
, St Pölten, , Austria
, St Veit An Der Glan, , Austria
, Steyr, , Austria
, Villach, , Austria
, Wels, , Austria
, Wiener Neustadt, , Austria
, Wien, , Austria
, Wien, , Austria
, Wien, , Austria
, Wien, , Austria
, Wien, , Austria
, Zams, , Austria
, Belo Horizonte, , Brazil
, Belo Horizonte, , Brazil
, Belo Horizonte, , Brazil
, Campinas, , Brazil
, Campinas, , Brazil
, Curitiba, , Brazil
, Curitiba, , Brazil
, Fortaleza, , Brazil
, Fortaleza, , Brazil
, Goiania, , Brazil
, Ijui, , Brazil
, JAU, , Brazil
, Joao Pessoa, , Brazil
, Niteroi, , Brazil
, Piracicaba, , Brazil
, Porto Alegre, , Brazil
, Porto Alegre, , Brazil
, Porto Alegre, , Brazil
, Porto Alegre, , Brazil
, Porto Alegre, , Brazil
, Recife, , Brazil
, Ribeirao Preto, , Brazil
, Rio de Janeiro, , Brazil
, Rio de Janeiro, , Brazil
, Rio de Janeiro, , Brazil
, Salvador, , Brazil
, Santos, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sao Paulo, , Brazil
, Sorocaba, , Brazil
, Vitoria, , Brazil
, Plovdiv, , Bulgaria
, Sofia, , Bulgaria
, Sofia, , Bulgaria
, Varna, , Bulgaria
, Veliko Tarnovo, , Bulgaria
, Surrey, British Columbia, Canada
, Barrie, Ontario, Canada
, Brampton, Ontario, Canada
, East York, Ontario, Canada
, Mississauga, Ontario, Canada
, Newmarket, Ontario, Canada
, Sault Ste Marie, Ontario, Canada
, Scarborough, Ontario, Canada
, St. Catharines, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Toronto, Ontario, Canada
, Windsor, Ontario, Canada
, Montreal, Quebec, Canada
, Regina, Saskatchewan, Canada
, Quebec, , Canada
, Beijing, , China
, Beijing, , China
, Chang Sha, , China
, Changchun, , China
, Chengdu, , China
, Chongqing, , China
, Guangzhou, , China
, Hang Zhou, , China
, He Fei, , China
, Nanjing, , China
, Shanghai, , China
, Shanghai, , China
, Suzhou, , China
, Tianjin, , China
, Cali, , Colombia
, Neiva, , Colombia
, Pereira, , Colombia
, Brno, , Czech Republic
, Hradec Kralove, , Czech Republic
, Ostrava, , Czech Republic
, Praha, , Czech Republic
, Quito, , Ecuador
, Alexandria, , Egypt
, Tallin, , Estonia
, Tartu, , Estonia
, Haemeenlinna, , Finland
, Kotka, , Finland
, Kuopio, , Finland
, Pori, , Finland
, Tampere, , Finland
, Turku, , Finland
, Vaasa, , Finland
, Ales, , France
, Angers, , France
, Avignon, , France
, Bayonne, , France
, Bayonne, , France
, Besancon, , France
, Bobigny, , France
, Bordeaux, , France
, Bordeaux, , France
, Boulogne Sur Mer, , France
, Boulogne-billancourt, , France
, Brest, , France
, Chalon Sur Saone, , France
, Chateauroux, , France
, Clermont-ferrand, , France
, Colmar, , France
, Creteil, , France
, DAX, , France
, Dijon, , France
, GAP, , France
, Grenoble, , France
, L'isle D'espagnac, , France
, La Chaussee St Victor, , France
, La Tronche, , France
, Le Chesnay, , France
, Le Coudray, , France
, Le Mans, , France
, Lille, , France
, Lyon, , France
, Mantes La Jolie, , France
, Marseille, , France
, Marseille, , France
, Metz, , France
, Metz, , France
, Mont-de-marsan, , France
, Montbeliard, , France
, Montfermeil, , France
, Montpellier, , France
, Mougins, , France
, Nancy, , France
, Nevers, , France
, Nimes, , France
, Niort, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Paris, , France
, Perigueux, , France
, Perpignan, , France
, Pierre Benite, , France
, Pontoise, , France
, Reims, , France
, Rouen, , France
, Saint Brieuc, , France
, Saint Gregoire, , France
, Saint Jean, , France
, Saint Pierre, , France
, Saint-cloud, , France
, Saint-denis de La Reunion, , France
, St-priest-en-jarez, , France
, Strasbourg, , France
, Strasbourg, , France
, Toulon, , France
, Toulouse, , France
, Toulouse, , France
, Tours, , France
, Valenciennes, , France
, Vandoeuvre Les Nancy, , France
, Vannes, , France
, Villeneuve-sur-lot, , France
, Augsburg, , Germany
, Bad Saarow, , Germany
, Berlin, , Germany
, Berlin, , Germany
, Berlin, , Germany
, Bielefeld, , Germany
, Bochum, , Germany
, Böblingen, , Germany
, Chemnitz, , Germany
, Cottbus, , Germany
, Deggendorf, , Germany
, Dresden, , Germany
, Duisburg, , Germany
, Düsseldorf, , Germany
, Erfurt, , Germany
, Essen, , Germany
, Frankfurt, , Germany
, Freiburg, , Germany
, Halle, , Germany
, Hamburg, , Germany
, Hamburg, , Germany
, Hannover, , Germany
, Hannover, , Germany
, Kassel, , Germany
, Kiel, , Germany
, Leipzig, , Germany
, Lübeck, , Germany
, Magdeburg, , Germany
, Magdeburg, , Germany
, Mainz, , Germany
, Mannheim, , Germany
, München, , Germany
, Regensburg, , Germany
, Rostock, , Germany
, Saarbruecken, , Germany
, Stralsund, , Germany
, Stuttgart, , Germany
, Stuttgart, , Germany
, Troisdorf, , Germany
, ULM, , Germany
, Unna, , Germany
, Wiesbaden, , Germany
, Wuerselen, , Germany
, Wuppertal, , Germany
, Hong Kong, , Hong Kong
, Hong Kong, , Hong Kong
, Budapest, , Hungary
, Budapest, , Hungary
, Szeged, , Hungary
, Beer Sheva, , Israel
, Haifa, , Israel
, Holon, , Israel
, Jerusalem, , Israel
, Jerusalem, , Israel
, Kfar Saba, , Israel
, Nahariya, , Israel
, Petach Tikva, , Israel
, Ramat-gan, , Israel
, Rehovot, , Israel
, Safed, , Israel
, Tel Aviv, , Israel
, Zerifin, , Israel
, Ancona, , Italy
, Aviano, , Italy
, Brescia, , Italy
, Cagliari, , Italy
, Cagliari, , Italy
, Candiolo, , Italy
, Carpi, , Italy
, Castelfranco Veneto, , Italy
, Castrovillari, , Italy
, Catania, , Italy
, Chieti, , Italy
, Como, , Italy
, Cremona, , Italy
, Frattamaggiore, , Italy
, Genova, , Italy
, Lecce, , Italy
, Lido Di Camaiore, , Italy
, Lucca, , Italy
, Mantova, , Italy
, Messina, , Italy
, Milano, , Italy
, Milano, , Italy
, Montevarchi, , Italy
, Napoli, , Italy
, Novara, , Italy
, Palermo, , Italy
, Paola, , Italy
, Pavia, , Italy
, Piove Di Sacco, , Italy
, Pordenone, , Italy
, Pozzuoli, , Italy
, Prato, , Italy
, Ravenna, , Italy
, Rionero in Vulture, , Italy
, Roma, , Italy
, Roma, , Italy
, Roma, , Italy
, Roma, , Italy
, Roma, , Italy
, Salerno, , Italy
, San Giovanni Rotondo, , Italy
, Saronno, , Italy
, Sassari, , Italy
, Siena, , Italy
, Torino, , Italy
, Verona, , Italy
, Vicenza, , Italy
, Riga, , Latvia
, Riga, , Latvia
, Beirut, , Lebanon
, Beirut, , Lebanon
, Kaunas, , Lithuania
, Klaipeda, , Lithuania
, Vilnius, , Lithuania
, Chihuahua, , Mexico
, Ciudad Juarez, , Mexico
, Guadalajara, , Mexico
, Leon, , Mexico
, Mexico City, , Mexico
, Mexico City, , Mexico
, Mexico City, , Mexico
, Mexico City, , Mexico
, Puebla, , Mexico
, Tijuana, , Mexico
, Rabat, , Morocco
, Rabat, , Morocco
, Ac Amsterdam, , Netherlands
, Blaricum, , Netherlands
, Capelle Ad Yssel, , Netherlands
, Delftzijl, , Netherlands
, Doetinchem, , Netherlands
, Goes, , Netherlands
, Hoofddorp, , Netherlands
, Vlissingen, , Netherlands
, Zoetermeer, , Netherlands
, Bydgoszcz, , Poland
, Lublin, , Poland
, Olsztyn, , Poland
, Poznan, , Poland
, Warszawa, , Poland
, Warszawa, , Poland
, Almada, , Portugal
, Aveiro, , Portugal
, Barreiro, , Portugal
, Beja, , Portugal
, Cascais, , Portugal
, Coimbra, , Portugal
, Lisboa, , Portugal
, Lisboa, , Portugal
, Lisboa, , Portugal
, Porto, , Portugal
, Porto, , Portugal
, Porto, , Portugal
, Santa Maria Da Feira, , Portugal
, Santarém, , Portugal
, Setubal, , Portugal
, Vila Nova de Gaia, , Portugal
, Balashikha, , Russian Federation
, Barnaul, , Russian Federation
, Ekaterinburg, , Russian Federation
, Engels, , Russian Federation
, Izhevsk, , Russian Federation
, Kazan, , Russian Federation
, Kazan, , Russian Federation
, Kursk, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Smolensk, , Russian Federation
, St Petersburg, , Russian Federation
, St Petersburg, , Russian Federation
, Stavropol, , Russian Federation
, Tumen, , Russian Federation
, Tver, , Russian Federation
, UFA, , Russian Federation
, Ulyanovsk, , Russian Federation
, Jeddah, , Saudi Arabia
, Riyadh, , Saudi Arabia
, Riyadh, , Saudi Arabia
, Banska Bystrica, , Slovakia
, Bratislava, , Slovakia
, Bratislava, , Slovakia
, Kosice, , Slovakia
, Poprad, , Slovakia
, Presov, , Slovakia
, Zilina, , Slovakia
, Ljubljana, , Slovenia
, Alcorcon, , Spain
, Barakaldo, , Spain
, Barcelona, , Spain
, Castellon, , Spain
, Gijon, , Spain
, Las Palmas de Gran Canaria, , Spain
, Logroño, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Manresa, , Spain
, Murcia, , Spain
, Navarra, , Spain
, Orense, , Spain
, Palma de Mallorca, , Spain
, Pontevedra, , Spain
, Sabadell, Barcelona, , Spain
, Sagunto, , Spain
, Salamanca, , Spain
, San Sebastian, , Spain
, San Sebastian, , Spain
, Santiago de Compostela, , Spain
, Terrassa, , Spain
, Terrassa, , Spain
, Valencia, , Spain
, Vigo, , Spain
, Zamora, , Spain
, Göteborg, , Sweden
, Jonkoping, , Sweden
, Kalmar, , Sweden
, Karlstad, , Sweden
, Malmoe, , Sweden
, Stockholm, , Sweden
, Sundsvall, , Sweden
, Vaxjo, , Sweden
, Västerås, , Sweden
, Aarau, , Switzerland
, Baden, , Switzerland
, Biel, , Switzerland
, Genolier, , Switzerland
, Locarno, , Switzerland
, Lugano, , Switzerland
, Adana, , Turkey
, Ankara, , Turkey
, Gaziantep, , Turkey
, Istanbul, , Turkey
, Istanbul, , Turkey
, Shhiye, Ankara, , Turkey
, Colchester, , United Kingdom
, Coventry, , United Kingdom
, Dundee, , United Kingdom
, Glasgow, , United Kingdom
, London, , United Kingdom
, Peterborough, , United Kingdom
, Sutton, , United Kingdom
, Truro, , United Kingdom
, Westcliffe-on-sea, , United Kingdom
, Worthing, , United Kingdom
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR