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Spots Global Cancer Trial Database for Breast MRI in Women With Known or Suspected Breast Cancer and in Healthy Participants

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Trial Identification

Brief Title: Breast MRI in Women With Known or Suspected Breast Cancer and in Healthy Participants

Official Title: MRI Evaluation of Breast Tumor Growth and Treatment Response

Study ID: NCT00474604

Conditions

Breast Cancer

Study Description

Brief Summary: RATIONALE: Diagnostic procedures, such as MRI, may help diagnose breast cancer. It may also help doctors predict a patient's response to treatment. PURPOSE: This clinical trial is studying breast MRI in women with known or suspected breast cancer and in healthy participants.

Detailed Description: OBJECTIVES: * Develop and combine advanced, quantitative, multiparametric magnetic resonance imaging methods (i.e., dynamic contrast-enhanced MRI \[DCE-MRI\], diffusion-weighted MRI \[DW-MRI\], and magnetic resonance spectroscopy \[MRS\]) to characterize breast tumors in women with known or suspected breast cancer. * Identify surrogate biomarkers that can guide diagnosis and treatment of breast cancer using these methods. * Correlate biochemical information obtained from magnetic resonance analysis with clinical, radiologic, and pathologic findings in these patients. * Establish an imaging data bank that includes information on DCE-MRI, DW-MRI, and MRS findings in these patients and in healthy participants. OUTLINE: Quantitative, multi-parametric magnetic imaging methods will be employed for breast imaging for the following subjects: * Group A: Healthy volunteers who undergo up to 3 breast MRIs over 6 weeks. * Group B: Patients diagnosed with breast cancer who will: 1) undergo preoperative breast MRI followed by definitive surgery or 2) undergo MRI prior to initiating neoadjuvant chemotherapy, at 1-2 weeks after initiation of chemotherapy, and prior to definitive surgery. Clinical information, including radiologic and pathologic data, on all patients is collected for inclusion in the imaging data bank. After completion of the study, patients and healthy participants are followed periodically.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

Vanderbilt-Ingram Cancer Center, Nashville, Tennessee, United States

Contact Details

Name: A. Bapsi Chakravarthy, MD

Affiliation: Vanderbilt-Ingram Cancer Center

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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