Spots Global Cancer Trial Database for Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer
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Trial Identification
Brief Title: Study of Statin as Neo-Adjuvant Therapy in Postmenopausal Breast Cancer
Official Title: A Phase II Study of Neo-Adjuvant Statin Therapy in Postmenopausal Primary Breast Cancer: A Window-of-Opportunity Study
Study ID: NCT00816244
Interventions
Study Description
Brief Summary: The purpose of this study is to monitor: * Tumor biological alterations following two weeks of neo-adjuvant statin therapy. * Effects of statins on tumor proliferation. * Functional studies on the mevalonate pathway.
Detailed Description: Blood samples and three core biopsies are taken after diagnosis. Treatment with atorvastatin at a daily dosis of 80 mg is initiated 14 days before planned surgery. Translational research will be performed from the core biopsy and blood samples taken before surgery and from the specimen from surgery.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Locations
University Hospital, Department of Oncology, Lund, , Sweden
Contact Details
Name: Carsten Rose, MD
Affiliation: University Hospital Lund
Role: PRINCIPAL_INVESTIGATOR
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