Spots Global Cancer Trial Database for Biomarkers in Native American Women With Breast Cancer

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Trial Identification

Brief Title: Biomarkers in Native American Women With Breast Cancer

Official Title: Molecular Markers in Native American Women With Breast Cancer

Study ID: NCT00898976

Conditions

Breast Cancer

Interventions

immunohistochemistry staining method

laboratory biomarker analysis

Study Description

Brief Summary: RATIONALE: Studying samples of tumor tissue in the laboratory from Native American women with breast cancer may help doctors identify and learn more about biomarkers related to breast cancer in these patients. It may also help doctors learn more about the prognosis of these patients. PURPOSE: This laboratory study is looking at biomarkers in Native American women with breast cancer.

Detailed Description: OBJECTIVES: * Evaluate a selected panel of molecular markers in tissue specimens from Native American women with breast cancer. * Determine which molecular markers provide independent prognostic information with respect to traditional prognostic factors in these patients. * Compare and contrast the prevalence of positivity in Native American women with breast cancer with an age- and stage-matched cohort of Caucasian women with breast cancer enrolled on clinical trial NCCTG-77-30-51 or the Mayo Breast Cancer Registry. OUTLINE: Immunohistochemistry is performed on tumor samples to analyze the following molecular markers: estrogen receptor, progesterone receptor, c-erbB2, p53, Ki-67, Bcl-2, Bax, cyclin D-1, and insulin-like growth factor-1R.