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Spots Global Cancer Trial Database for TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen

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Trial Identification

Brief Title: TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen

Official Title: A Phase II TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen Composed of Doxorubicin and Paclitaxel

Study ID: NCT02053597

Conditions

Breast Cancer

Study Description

Brief Summary: Recently, there has been a rising trend of delaying childbearing and hence more women are diagnosed with breast cancer before completing their families. Given the continuous decline in recurrences and death secondary to breast cancer and the reassuring data on the safety of pregnancy following breast cancer more women are inquiring into the possibility of preserving fertility following chemotherapy. The challenge remains in using a regimen that is devoid of cyclophosphamide, but is as effective as the standard regimens that incorporate cyclophosphamide. The combination doxorubicin (50 mg/m2) and paclitaxel (200 mg/m2) (AP) followed by 12 weeks of paclitaxel (80 mg/m2) (P) emerges as a treatment option with convincing results regarding its effectiveness in the early setting, and could be potentially associated with less ovarian toxicity being devoid of cyclophosphamide.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

GZA Ziekenhuisen Campus Sint-Augustinus - Iridium Kankernetwerk, Antwerp, Wilrijk, Belgium

Jules Bordet Institute, Brussels, , Belgium

Hôpital Erasme, Brussels, , Belgium

Clinique et Maternité Sainte Elisabeth, Namur, , Belgium

Contact Details

Name: Daphné Tkint de Roodenbeke, MD, PhD

Affiliation: Jules Bordet Institute

Role: PRINCIPAL_INVESTIGATOR

Name: Hatem Azim, MD, PhD

Affiliation: Jules Bordet Institute

Role: PRINCIPAL_INVESTIGATOR

Name: Isabelle Demeestere, MD, PhD

Affiliation: Hôpital Erasme

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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