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Brief Title: A Study of LY3484356 in Participants With Advanced or Metastatic Breast Cancer or Endometrial Cancer
Official Title: EMBER: A Phase 1a/1b Study of LY3484356 Administered as Monotherapy and in Combination With Anticancer Therapies for Patients With ER+ Locally Advanced or Metastatic Breast Cancer and Other Select Non-Breast Cancers
Study ID: NCT04188548
Brief Summary: The reason for this study is to see if the study drug LY3484356 alone or in combination with other anticancer therapies is safe and effective in participants with advanced or metastatic breast cancer or endometrial cancer.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Banner MD Anderson Cancer Center, Gilbert, Arizona, United States
Mayo Clinic in Arizona - Phoenix, Phoenix, Arizona, United States
Highlands Oncology Group, Springdale, Arkansas, United States
Beverly Hills Cancer Center, Beverly Hills, California, United States
University of California, Irvine, Orange, California, United States
UCSF Medical Center at Mission Bay, San Francisco, California, United States
Mayo Clinic in Florida, Jacksonville, Florida, United States
Lake Nona DDU, Orlando, Florida, United States
Winship Cancer Center Emory University, Atlanta, Georgia, United States
Northwestern University, Chicago, Illinois, United States
Community Cancer Center North, Indianapolis, Indiana, United States
Johns Hopkins University, Baltimore, Maryland, United States
Massachusetts General Hospital, Boston, Massachusetts, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
Minnesota Oncology/Hematology PA, Minneapolis, Minnesota, United States
Mayo Clinic, Rochester, Minnesota, United States
Washington University, Saint Louis, Missouri, United States
Memorial Sloan Kettering - Bergen, Montvale, New Jersey, United States
Memorial Sloan Kettering Cancer Center, Commack, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Wilmot Cancer Institute, Rochester, New York, United States
University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States
Duke University, Durham, North Carolina, United States
Ohio State University Medical Center, Columbus, Ohio, United States
University of Oklahoma Health Sciences Center, Stephenson Cancer Center, Oklahoma City, Oklahoma, United States
Asante Rogue Regional Medical Center, Medford, Oregon, United States
UPMC Hillman Cancer Center Harrisburg, Harrisburg, Pennsylvania, United States
Rhode Island Hospital, Providence, Rhode Island, United States
Vanderbilt Health One Hundred Oaks, Nashville, Tennessee, United States
SCRI Oncology Partners, Nashville, Tennessee, United States
Tennessee Oncology Nashville, Nashville, Tennessee, United States
UT Southwestern Med Center, Dallas, Texas, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
University of Texas MD Anderson Cancer Center, Houston, Texas, United States
South Texas Accelerated Research Therapeutics (START), San Antonio, Texas, United States
Minnesota Oncology/Hematology PA, The Woodlands, Texas, United States
Oncology and Hematology Associates of Southwest Virginia Inc, The Woodlands, Texas, United States
Texas Oncology - San Antonio Medical Center, The Woodlands, Texas, United States
US Oncology, The Woodlands, Texas, United States
USO-Rocky Mountain Cancer Center, The Woodlands, Texas, United States
Texas Oncology - Tyler, Tyler, Texas, United States
The University of Vermont Medical Center Inc., Burlington, Vermont, United States
Inova Schar Cancer Institute, Fairfax, Virginia, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
Calvary Mater Newcastle, Waratah, New South Wales, Australia
Cancer Research SA, Adelaide, South Australia, Australia
Breast Cancer Research Centre-WA, Nedlands, Western Australia, Australia
Linear Clinical Research, Nedlands, Western Australia, Australia
Antwerp University Hospital, Edegem, Antwerpen, Belgium
Institut Jules Bordet, Anderlecht, Bruxelles-Capitale, Région De, Belgium
UZ Leuven, Leuven, , Belgium
Institut Curie, Paris, , France
Institut de cancérologie Strasbourg Europe (ICANS), Strasbourg, , France
Hyogo Cancer Center, Akashi, Hyogo, Japan
National Cancer Center Hospital, Chuo-ku, Tokyo, Japan
Severance Hospital, Yonsei University Health System, Seoul, Korea, Korea, Republic of
Seoul National University Hospital, Seoul, Seoul, Korea, Korea, Republic of
Asan Medical Center, Seoul, Seoul-teukbyeolsi [Seoul], Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Hospital Clínic de Barcelona, Barcelona, Catalunya [Cataluña], Spain
Hospital Universitario 12 de Octubre, Madrid, Madrid, Comunidad De, Spain
Hospital Clínico Universitario de Valencia, Valencia, Valenciana, Comunitat, Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital General Universitario Gregorio Marañon, Madrid, , Spain
Hospital Universitario Ramón y Cajal, Madrid, , Spain
Hospital Clinico San Carlos, Madrid, , Spain
Hospital Universitario Fundación Jiménez Díaz, Madrid, , Spain
Hospital Universitario HM Sanchinarro, Madrid, , Spain
Fundación Instituto Valenciano de Oncología, Valencia, , Spain
Kaohsiung Medical University Hospital, Kaohsiung, , Taiwan
China Medical University Hospital, Taichung, , Taiwan
National Cheng-Kung Uni. Hosp., Tainan, , Taiwan
National Taiwan University Hospital, Taipei, , Taiwan
Mackay Memorial Hospital, Taipei, , Taiwan
Taipei Veterans General Hospital, Taipei, , Taiwan
Name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
Affiliation: Eli Lilly and Company
Role: STUDY_DIRECTOR