Spots Global Cancer Trial Database for Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
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Trial Identification
Brief Title: Trastuzumab Deruxtecan (T-DXd) Alone or in Sequence With THP, Versus Standard Treatment (ddAC-THP), in HER2-positive Early Breast Cancer
Official Title: A Phase 3 Open-label Trial of Neoadjuvant Trastuzumab Deruxtecan (T-DXd) Monotherapy or T-DXd Followed by THP Compared to ddAC-THP in Participants With High-risk HER2-positive Early-stage Breast Cancer (DESTINY-Breast11)
Study ID: NCT05113251
Study Description
Brief Summary: This study will look at the efficacy and safety of trastuzumab deruxtecan (T-DXd) in a neoadjuvant setting, in high-risk, HER2-positive early non-metastatic breast cancer.
Detailed Description: The target population of interest in this study is participants with high-risk HER2-positive early-stage breast cancer. The purpose of this study is to determine the efficacy and safety of T-DXd neoadjuvant therapy. Participants will be randomised to one of 3 arms: T-DXd monotherapy (Arm A), T-DXd followed by THP (Arm B), or ddAC-THP (Arm C).
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Research Site, Springdale, Arkansas, United States
Research Site, Beverly Hills, California, United States
Research Site, Glendale, California, United States
Research Site, Los Alamitos, California, United States
Research Site, Orange, California, United States
Research Site, New Haven, Connecticut, United States
Research Site, Fort Wayne, Indiana, United States
Research Site, Lexington, Kentucky, United States
Research Site, Louisville, Kentucky, United States
Research Site, Shreveport, Louisiana, United States
Research Site, Minneapolis, Minnesota, United States
Research Site, Las Vegas, Nevada, United States
Research Site, East Brunswick, New Jersey, United States
Research Site, Summit, New Jersey, United States
Research Site, Commack, New York, United States
Research Site, Durham, North Carolina, United States
Research Site, Greenville, South Carolina, United States
Research Site, Germantown, Tennessee, United States
Research Site, Nashville, Tennessee, United States
Research Site, Fort Worth, Texas, United States
Research Site, Ogden, Utah, United States
Research Site, Tacoma, Washington, United States
Research Site, Goiânia, , Brazil
Research Site, Ijuí, , Brazil
Research Site, Natal, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, Porto Alegre, , Brazil
Research Site, São Paulo, , Brazil
Research Site, São Paulo, , Brazil
Research Site, Panagyurishte, , Bulgaria
Research Site, Sofia, , Bulgaria
Research Site, Edmonton, Alberta, Canada
Research Site, Toronto, Ontario, Canada
Research Site, Montreal, Quebec, Canada
Research Site, Quebec City, Quebec, Canada
Research Site, Sherbrooke, Quebec, Canada
Research Site, Montreal, , Canada
Research Site, Beijing, , China
Research Site, Changsha, , China
Research Site, Changsha, , China
Research Site, Chongqing, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Guangzhou, , China
Research Site, Kunming, , China
Research Site, Nanjing, , China
Research Site, Nanning, , China
Research Site, Qingdao, , China
Research Site, Shanghai, , China
Research Site, Shanghai, , China
Research Site, Shenyang, , China
Research Site, Tianjin, , China
Research Site, Wuhan, , China
Research Site, Wuhan, , China
Research Site, Zhengzhou, , China
Research Site, Augsburg, , Germany
Research Site, Berlin, , Germany
Research Site, Erlangen, , Germany
Research Site, Hamburg, , Germany
Research Site, Heidelberg, , Germany
Research Site, Kiel, , Germany
Research Site, Leipzig, , Germany
Research Site, Muenster, , Germany
Research Site, Mönchengladbach, , Germany
Research Site, München, , Germany
Research Site, Paderborn, , Germany
Research Site, Tübingen, , Germany
Research Site, Gurgaon, , India
Research Site, Howrah, , India
Research Site, Nagpur, , India
Research Site, Nashik, , India
Research Site, New Delhi, , India
Research Site, New Delhi, , India
Research Site, Raipur, , India
Research Site, Rishikesh, , India
Research Site, Surat, , India
Research Site, Thiruvananthapuram, , India
Research Site, Bologna, , Italy
Research Site, Candiolo, , Italy
Research Site, Livorno, , Italy
Research Site, Milano, , Italy
Research Site, Naples, , Italy
Research Site, Napoli, , Italy
Research Site, Negrar, , Italy
Research Site, Padova, , Italy
Research Site, Rome, , Italy
Research Site, Rozzano, , Italy
Research Site, Chuo-ku, , Japan
Research Site, Chuo-ku, , Japan
Research Site, Hidaka-shi, , Japan
Research Site, Hiroshima-shi, , Japan
Research Site, Kawasaki-shi, , Japan
Research Site, Koto-ku, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Nagoya-shi, , Japan
Research Site, Ota-shi, , Japan
Research Site, Shinjuku-ku, , Japan
Research Site, Goyang-si, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Seoul, , Korea, Republic of
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Lima, , Peru
Research Site, Bacolod, , Philippines
Research Site, Cebu City, , Philippines
Research Site, Davao City, , Philippines
Research Site, Iloilo, , Philippines
Research Site, Quezon City, , Philippines
Research Site, San Juan, , Philippines
Research Site, Biała Podlaska, , Poland
Research Site, Białystok, , Poland
Research Site, Bydgoszcz, , Poland
Research Site, Koszalin, , Poland
Research Site, Lublin, , Poland
Research Site, Rzeszów, , Poland
Research Site, Warszawa, , Poland
Research Site, Moscow, , Russian Federation
Research Site, Moscow, , Russian Federation
Research Site, Saint Petersburg, , Russian Federation
Research Site, Saint Petersburg, , Russian Federation
Research Site, Ar Riyāḑ, , Saudi Arabia
Research Site, Dammam, , Saudi Arabia
Research Site, Jeddah, , Saudi Arabia
Research Site, Jeddah, , Saudi Arabia
Research Site, Riyadh, , Saudi Arabia
Research Site, Barcelona, , Spain
Research Site, Barcelona, , Spain
Research Site, Madrid, , Spain
Research Site, Madrid, , Spain
Research Site, Sevilla, , Spain
Research Site, Vigo, , Spain
Research Site, Kaohsiung, , Taiwan
Research Site, Taichung, , Taiwan
Research Site, Tainan, , Taiwan
Research Site, Taipei 112, , Taiwan
Research Site, Taipei City, , Taiwan
Research Site, Taipei, , Taiwan
Research Site, Taoyuan, , Taiwan
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Bangkok, , Thailand
Research Site, Chiang Mai, , Thailand
Research Site, Hat Yai, , Thailand
Research Site, Khon Kaen, , Thailand
Contact Details
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