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Brief Title: Study to Evaluate Markers of Response in Locally Advanced Breast Cancer
Official Title: A Multicenter Phase II Study, to Evaluate the Predictive Markers of Response in Locally Advanced Breast Cancer, Treated With Bevacizumab Combined With Neoadjuvant Chemotherapy
Study ID: NCT01338753
Brief Summary: The purpose of this study is to compare the association between image and certain molecular markers with complete response in patients with locally advanced breast cancer, treated with neoadjuvant chemotherapy composed of Bevacizumab, Docetaxel and Doxorubicin.
Detailed Description: This is a pharmacogenomic phase II, multicenter, prospective clinical trial whose main objective is to evaluate the association of molecular and imaging markers with the response to bevacizumab administration in combination with docetaxel and doxorubicin as neoadjuvant chemotherapy in patients diagnose with locally advanced breast cancer.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Hospital Obispo Polanco, Teruel, Aragón, Spain
Hospital Miguel Servet, Zaragoza, Aragón, Spain
Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain
Hospital de Donosti, San Sebastián, Guipúzcoa, Spain
Onkologikoa, San Sebastián, Guipúzcoa, Spain
Hospital de San Millan, Logroño, La Rioja, Spain
Clinica Universitaria de Navarra, Pamplona, Navarra, Spain
Hospital de Navarra, Pamplona, Navarra, Spain
Hospital de Tudela, Tudela, Navarra, Spain
Hospital de Basurto, Bilbao, Vizcaya, Spain
Hospital General Yagüe, Burgos, , Spain
Name: Antonio Anton, MD
Affiliation: Hospital Miguel Servet
Role: PRINCIPAL_INVESTIGATOR
Name: Jesus Garcia-Foncillas, MD
Affiliation: Clinica Universitaria de Navarra
Role: PRINCIPAL_INVESTIGATOR
Name: Alfonso Yubero, MD
Affiliation: Hospital Obispo Polanco
Role: PRINCIPAL_INVESTIGATOR
Name: Isabel Alvarez, MD
Affiliation: Hospital Donosti
Role: PRINCIPAL_INVESTIGATOR
Name: Jose Manuel Lopez-Vega, MD
Affiliation: Hospital Universitario Marqués de Valdecilla
Role: PRINCIPAL_INVESTIGATOR
Name: Blanca Hernando, MD
Affiliation: Hospital General Yagüe
Role: PRINCIPAL_INVESTIGATOR
Name: Jose Juan Illarramendi, Md
Affiliation: Hospital de Navarra
Role: PRINCIPAL_INVESTIGATOR
Name: Irene Gil, MD
Affiliation: Hospital de Tudela
Role: PRINCIPAL_INVESTIGATOR
Name: Purificacion Martinez del Prado, MD
Affiliation: Hospital de Basurto
Role: PRINCIPAL_INVESTIGATOR
Name: Rosa Sanchez, MD
Affiliation: Complejo Hospitalario San Millán San Pedro De La Rioja
Role: PRINCIPAL_INVESTIGATOR
Name: Arrate Plazaola, MD
Affiliation: Onkologikoa
Role: PRINCIPAL_INVESTIGATOR
Name: Serafin Morales, MD
Affiliation: Hospital Universitario Arnau Vilanova de Lleida
Role: PRINCIPAL_INVESTIGATOR