Spots Global Cancer Trial Database for Study the Role of Stem Cell in Curing Drug Induced Liver Injury in Metastatic Breast Cancer (MBC)

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Trial Identification

Brief Title: Study the Role of Stem Cell in Curing Drug Induced Liver Injury in Metastatic Breast Cancer (MBC)

Official Title: Study the Role of Stem Cell in Curing Drug Induced Liver Injury in Metastatic Breast Cancer

Study ID: NCT01231022

Conditions

Breast Neoplasms

Neoplasm Metastasis

Interventions

Study Description

Brief Summary: The investigators want to know the role of Peripheral hematopoietic stem cell infusion in avoiding Drug Induced Liver Injury,and also try to research SNPs genotyping associated with Drug Induced Liver Injury.

Detailed Description: 1. The researcher investigate the incidence and the cause of Drug Induced Liver Injury in MBC. 2. Patients having a complete clinical history and physical examination, receive routine chemotherapy. 3. Venous blood Sample(4 ml)is collected before and after each cycle according to the planning time. 4. Genomic DNA,RNA and upper serum is isolated. ELISA、rt-PCR or PCR-direct sequencing is used to detect the protein or gene expression associated with liver function.