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Brief Title: A Study of Palbociclib (PD-0332991) + Letrozole vs. Letrozole For 1st Line Treatment Of Postmenopausal Women With ER+/HER2- Advanced Breast Cancer (PALOMA-2)
Official Title: A RANDOMIZED, MULTICENTER, DOUBLE-BLIND PHASE 3 STUDY OF PD-0332991 (ORAL CDK 4/6 INHIBITOR) PLUS LETROZOLE VERSUS PLACEBO PLUS LETROZOLE FOR THE TREATMENT OF POSTMENOPAUSAL WOMEN WITH ER (+), HER2 (-) BREAST CANCER WHO HAVE NOT RECEIVED ANY PRIOR SYSTEMIC ANTI CANCER TREATMENT FOR ADVANCED DISEASE
Study ID: NCT01740427
Brief Summary: The study is designed to compare the clinical benefit following treatment with letrozole in combination with PD-0332991 versus letrozole in combination with placebo in postmenopausal women with ER(+)/HER2(-) advanced breast cancer who have not received prior systemic anti cancer therapies for their advanced/metastatic disease.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: No
Southern California Permanente Medical Group, Bellflower, California, United States
Beverly Hills Cancer Center, Beverly Hills, California, United States
St. Joseph Heritage Healthcare, Fullerton, California, United States
Los Angeles Hematology/Oncology Medical Group, Glendale, California, United States
UCLA Hematology/ Oncology- Irvine, Irvine, California, United States
UCLA Hematology Oncology- Laguna Hills, Laguna Hills, California, United States
Los Angeles Hematology/Oncology Medical Group, Los Angeles, California, United States
Southern California Permanente Medical Group, Los Angeles, California, United States
Translational Research Management, Los Angeles, California, United States
Drug Management Only: UCLA West Medical Pharmacy, Attn: Steven L Wong, Pharm.D., Los Angeles, California, United States
UCLA West Medical Pharmacy, Attn: Steven L. Wong, Los Angeles, California, United States
UCLA West Medical Pharmacy: Drug Management Only, Los Angeles, California, United States
UCLA West Medical Pharmacy; Drug Management Only, Los Angeles, California, United States
UCLA West Medical Pharmacy, Los Angeles, California, United States
Administrative Address: UCLA Hematology/Oncology, Los Angeles, California, United States
Drug Management Only: TRIO-US Pharmacy UCLA Medical Plaza, Attn: Steven L Wong, Pharm.D., Los Angeles, California, United States
Regulatory Management Only: TRIO-US Central Administration, Los Angeles, California, United States
Ronald Reagan UCLA Medical Center, Los Angeles, California, United States
TRIO-US Central Administration: Regulatory Management Only, Los Angeles, California, United States
TRIO-US Central Administration, Los Angeles, California, United States
UCLA Hematology Oncology, Los Angeles, California, United States
UCLA Hematology/Oncology, Los Angeles, California, United States
UCLA Hematology/ Oncology- Pasadena, Pasadena, California, United States
Torrance Health Association, DBa Torrance Memorial Physician Network, Redondo Beach, California, United States
Southern California Permanente Medical Group, San Diego, California, United States
University of California, San Francisco, San Francisco, California, United States
University of California San Francisco - Helen Diller Family Comprehensive Cancer Center, San Francisco, California, United States
San Luis Obispo Oncology and Hematology Health Center/ Pacific Central Coast Health Centers, San Luis Obispo, California, United States
Central Coast Medical Oncology Corporation, Santa Maria, California, United States
UCLA Santa Monica Medical Center and Orthopaedic Hospital, Santa Monica, California, United States
Stanford Women's Cancer Center, Stanford, California, United States
Wellness Oncology & Hematology, West Hills, California, United States
UCLA Hematology/Oncology- Westlake, Westlake Village, California, United States
St. Mary's Hospital Regional Cancer Center, Grand Junction, Colorado, United States
Smilow Cancer Hospital at Yale New Haven, New Haven, Connecticut, United States
Whittingham Cancer Center @ Norwalk Hospital, Norwalk, Connecticut, United States
MedStar Georgetown University Hospital, Washington, District of Columbia, United States
Sylvester at Deerfield Beach, Deerfield Beach, Florida, United States
Memorial Breast Cancer Center at Memorial Regional Hospital, Hollywood, Florida, United States
Memorial Cancer Institute at Memorial Regional Hospital, Hollywood, Florida, United States
Memorial Regional Hospital, Hollywood, Florida, United States
Cancer Specialist of North Florida, Pharmacy, Jacksonville, Florida, United States
Cancer Specialists of North Florida-Southpoint, Jacksonville, Florida, United States
Orlando Health, Inc., Orlando, Florida, United States
Memorial Breast Cancer Center at Memorial Hospital West, Pembroke Pines, Florida, United States
Memorial Cancer Institute at Memorial Hospital West, Pembroke Pines, Florida, United States
Memorial Hospital West, Pembroke Pines, Florida, United States
Sylvester Comprehensive Cancer Center Plantation, Plantation, Florida, United States
Cancer Specialists of North Florida - St. Augustine, Saint Augustine, Florida, United States
Grady Health System, Atlanta, Georgia, United States
Emory University Hospital Midtown, Atlanta, Georgia, United States
Emory University Hospital, Atlanta, Georgia, United States
The Emory Clinic, Atlanta, Georgia, United States
Winship Cancer Institute, Atlanta, Georgia, United States
Northwest Georgia Oncology Centers, PC, Marietta, Georgia, United States
Kootenai Clinic Cancer Services, Coeur d'Alene, Idaho, United States
Kootenai Clinic Cancer Services, Post Falls, Idaho, United States
The Mark M. Connolly Center for Cancer and Specialty Care, Chicago, Illinois, United States
Carle Foundation Hospital DBA Carle Cancer Center, Danville, Illinois, United States
Carle Foundation Hospital DBA Carle Cancer Center, Effingham, Illinois, United States
Presence Infusion Care- Evanston, Evanston, Illinois, United States
Carle Foundation Hospital DBA Carle Cancer Center, Mattoon, Illinois, United States
Presence Infusion Care- Skokie, Skokie, Illinois, United States
Carle Foundation Hospital DBA Carle Cancer Center, Urbana, Illinois, United States
James Graham Brown Cancer Center and University Hospital, Louisville, Kentucky, United States
James Graham Brown Cancer Center, Louisville, Kentucky, United States
University of Maryland, Greenebaum Cancer Center, Baltimore, Maryland, United States
Walter Reed National Military Medical Center, Bethesda, Maryland, United States
University of Michigan Health System, Ann Arbor, Michigan, United States
Park Nicollet Frauenshuh Cancer Center, Saint Louis Park, Minnesota, United States
The West Clinic, PC, Corinth, Mississippi, United States
The West Clinic, PC dba West Cancer Centre, Southaven, Mississippi, United States
Mercy Clinic St. Louis Cancer and Breast Institute, Ballwin, Missouri, United States
Mercy Clinic St. Louis Cancer and Breast Institute, Saint Louis, Missouri, United States
Mercy Hospital St. Louis - David C. Pratt Cancer Center, Saint Louis, Missouri, United States
Mercy Hospital St. Louis, Saint Louis, Missouri, United States
Saint Francis Medical Center, Grand Island, Nebraska, United States
Saint Francis Medical Center, Saint Francis Cancer Treatment Center, Grand Island, Nebraska, United States
Saint Francis Medical Center, Hastings, Nebraska, United States
Comprehensive Cancer Centers of Nevada, Henderson, Nevada, United States
Comprehensive Cancer Centers of Nevada, Henderson, Nevada, United States
Regulatory Office: Comprehensive Cancer Centers of Nevada Research Department, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
Comprehensive Cancer Centers of Nevada, Las Vegas, Nevada, United States
CareMount Medical, Brewster, New York, United States
CareMount Medical, Mount Kisco, New York, United States
Northern Westchester Hospital, Mount Kisco, New York, United States
Columbia University Medical Center, New York, New York, United States
Stony Brook University- Cancer Center, Stony Brook, New York, United States
Northwest Cancer Specialists, PC, Portland, Oregon, United States
Kaiser Permanente Northwest Region, Portland, Oregon, United States
Northwest Cancer Specialists, P.C., Portland, Oregon, United States
OHSU Center for Health and Healing 2, Portland, Oregon, United States
OHSU Center for Health and Healing, Portland, Oregon, United States
OHSU Research Pharmacy Services, Portland, Oregon, United States
Oregon Health and Science University, Portland, Oregon, United States
Tennessee Oncology, PLLC, Dickson, Tennessee, United States
Tennessee Oncology PLLC, Franklin, Tennessee, United States
Tennessee Oncology, PLLC, Gallatin, Tennessee, United States
The West Clinic, PC dba West Cancer Centre, Germantown, Tennessee, United States
Tennessee Oncology PLLC, Hermitage, Tennessee, United States
Tennessee Oncology, PLLC, Lebanon, Tennessee, United States
The West Clinic, PC dba West Cancer Centre, Memphis, Tennessee, United States
Tennessee Oncology PLLC, Murfreesboro, Tennessee, United States
Sarah Cannon Research Institute, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Nashville, Tennessee, United States
Tennessee Oncology PLLC, Nashville, Tennessee, United States
Tennessee Oncology PLLC, Nashville, Tennessee, United States
Tennessee Oncology PLLC, Nashville, Tennessee, United States
Tennessee Oncology, PLLC, Shelbyville, Tennessee, United States
Tennessee Oncology PLLC, Smyrna, Tennessee, United States
Texas Oncology-Dallas Presbyterian Hospital, Dallas, Texas, United States
Texas Oncology-Baylor Charles A. Sammons Cancer Center, Dallas, Texas, United States
Texas oncology-west Texas, El Paso, Texas, United States
Texas oncology-West Texas, El Paso, Texas, United States
Texas Oncology-west Texas, El Paso, Texas, United States
Investigational Products Center (IPC), Fort Worth, Texas, United States
The University of Texas MD Anderson Cancer Center, Department of Breast Medical Oncology, Houston, Texas, United States
The University of Texas MD Anderson Cancer Center., Houston, Texas, United States
The University of Texas MD Anderson Cancer Center, Houston, Texas, United States
US Oncology Investigational Products Center, Irving, Texas, United States
Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care, Blacksburg, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Low Moor, Virginia, United States
Virginia Oncology Associates, Newport News, Virginia, United States
Virginia oncology Associates, Norfolk, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Roanoke, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, Inc. D.B.A Blue Ridge Cancer Care, Salem, Virginia, United States
Virginia Oncology Associates, Virginia Beach, Virginia, United States
Shenandoah Oncology PC, Winchester, Virginia, United States
Oncology & Hematology Associates of Southwest Virginia, INC., D.B.A. Blue Rigde Cancer Care, Wytheville, Virginia, United States
Seattle Cancer Care Alliance, Seattle, Washington, United States
Northwest Cancer Specialists, P.C., Vancouver, Washington, United States
Northwest Cancer Specialists P.C., Vancouver, Washington, United States
WVU Medicine, Morgantown, West Virginia, United States
University of Wisconsin, Madison, Wisconsin, United States
St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia
Laverty Pathology, Port Macquarie, New South Wales, Australia
Mid North Coast Diagnostic Imaging, Port Macquarie, New South Wales, Australia
Calvary Mater Newcastle, Waratah, New South Wales, Australia
Icon Cancer Care, Auchenflower, Queensland, Australia
Sunshine Coast University Hospital, Birtinya, Queensland, Australia
Icon Cancer Care Corporate Office, South Brisbane, Queensland, Australia
Princess Alexandra Hospital, Woolloongabba, Queensland, Australia
Royal Adelaide Hospital, Adelaide, South Australia, Australia
Bendigo Health Care Group, The Bendigo Hospital Campus, Bendigo, Victoria, Australia
Northern Hospital, Epping, Victoria, Australia
Royal Melbourne Hospital, Parkville, Victoria, Australia
Epworth Healthcare, Richmond, Victoria, Australia
Maroondah Hospital, Ringwood East, Victoria, Australia
Goulburn Valley Health, Shepparton, Victoria, Australia
Fiona Stanley Hospital, Murdoch, Western Australia, Australia
Gasthuis Zusters Antwerpen - Campus Sint- Augustinus, Wilrijk, Antwerpen, Belgium
Institut Jules Bordet, Brussels, , Belgium
Oncologie, Brussels, , Belgium
UZ Brussel, Brussel, , Belgium
Grand Hopital de Charleroi / Service d'Hematologie et Oncologie, Charleroi, , Belgium
Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg, Leuven, , Belgium
CHU Start Tilman, Liege, , Belgium
CHR East Belgium - Verviers, Verviers, , Belgium
Tom Baker Cancer Centre, Calgary, Alberta, Canada
Cross Cancer Institute, Edmonton, Alberta, Canada
BC Cancer Agency-Fraser Valley Centre, Surrey, British Columbia, Canada
British Columbia Cancer Agency-Vancouver Centre, Vancouver, British Columbia, Canada
QEII Health Sciences Centre, Victoria General Site, Halifax, Nova Scotia, Canada
London Regional Cancer Program, London, Ontario, Canada
Southlake Regional Health Centre- Stronach Regional Cancer Centre, Newmarket, Ontario, Canada
Sunnybrook Research Institute, Toronto, Ontario, Canada
St. Michaels Hospital, Toronto, Ontario, Canada
Princess Margaret Cancer Centre, Toronto, Ontario, Canada
McGill University Health Centre (MUHC), Glen Site, Cedars Cancer Centre, Montreal, Quebec, Canada
Hopital du Sacre-Coeur, Montreal, Quebec, Canada
Center Hospitalier Affilie Universitaire de Quebec, Universite Laval, Hopital du Saint Sacrement, Quebec City, Quebec, Canada
Allan Blair Cancer Centre, Regina, Saskatchewan, Canada
Fakultni nemocnice Hradec Kralove, Klinika onkologie a radiologie, Hradec Kralove, , Czechia
Institut de Cancerologie de l'Ouest- Paul Papin, Anger Cedex 02, , France
Centre François Baclesse, Caen Cedex 5, , France
Centre Georges François Leclerc, Dijon, , France
CHD Vendée, La Roche Sur Yon, , France
Centre Val d'Aurelle,, Montpellier CEDEX 5, , France
Centre Antoine Lacassagne, Nice cedex 2, , France
Institut Curie, Departement d'Oncologie Medicale, Paris Cedex 05, , France
Centre Eugene Marquis, Rennes, , France
Hopital Rene Huguenin/Institut Curie, Saint-Cloud, , France
Institut de Cancérologie de l'Ouest-Rene Gauducheau, St Herblain, , France
Institut Claudius Regaud- Cancer Comprehensive Center- IUCT-O-Medical Oncology Department, Toulouse CEDEX-9, , France
Institut Gustave Roussy, Villejuif, , France
IOZ- Munchen, PGM- Studien GmbH, Muenchen, Bavaria, Germany
Klinikverbund Sudwest - Kliniken Sidelfingen-Boblingen, Boblingen, , Germany
University Hospital Carl Gustav Carus - Department for Obstetrics and Gynecology., Dresden, , Germany
Universitatsklinikum Erlangen, Frauenklinik, Erlangen, , Germany
Universitaetsklinikum Hamburg-Eppendorf, Hamburg, , Germany
Universitatsklinikum Schleswig-Holstein, Campus Kiel, Klinik für Gynakologie und Geburtshilfe, Kiel, , Germany
Universitaetsklinikum Magdeburg AOR Universitaetsfrauenklinik, Magdeburg, , Germany
Katholisches Klinikum Mainz, Mainz, , Germany
Frauenklinik und Poliklinik Klinikum rechts der Isar, Technische Universitaet Muenchen, Muenchen, , Germany
Rotkreuzklinikum Munchen, Frauenklinik,, Munich, , Germany
Breast Cancer, University of Munich, Grosshadern Hospital, Munich, , Germany
Klinikum Mutterhaus, Trier, , Germany
Szent Margit Korhaz, Budapest, , Hungary
Affidea Diagnosztika Kft., Budapest, , Hungary
Orszagos Onkologiai Intezet ,, Budapest, , Hungary
Országos Onkológiai Intézet "B" Belgyogyaszati osztaly, Budapest, , Hungary
Országos Onkológiai Intézet, Nuklearis Medicina Osztaly, Budapest, , Hungary
Országos Onkológiai Intézet, Radiologiai Diagnosztikai Osztily, Budapest, , Hungary
Petz Aladar Megyei Oktato Korhaz, Onkoradiologiai Osztaly, Györ, , Hungary
Josa Andras Teaching Hospital,, Nyiregyhaza, , Hungary
Szegedi Tudomanyegyetem Altalanos Orvosi Kar, Patologia Intezet, Szeged, , Hungary
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont, Altalanos Orvostudomanyi Kar, Szeged, , Hungary
Diagnoscan Magyarorszag Kft., Szeged, , Hungary
Bon Secours Hospital, Cork, , Ireland
St Vincents University Hospital, Dublin 4, , Ireland
St. James Hospital, Dublin, , Ireland
Beaumont Hospital, Dublin, , Ireland
Mater Misericordiae University Hospital, Dublin, , Ireland
Department of Medical Oncology, Galway, , Ireland
Mid Western Regional Hospital, Limerick, , Ireland
Waterford Regional Hospital, Waterford, , Ireland
Azienda Ospedaliero-Universitaria di Bologna, Policlinico Sant'Orsola-Malpighi, Bologna, BO, Italy
Irccs Irst, Meldola, FC, Italy
IRCCS - Istituto Europeo di Oncologia, Milano, Milan, Italy
Azienda Ospedaliera San Giuseppe Moscati, Avellino, , Italy
Azienda Ospedaliero-Universitaria Pisana, Pisa, , Italy
Istituti Fisioterapici Ospitalieri, Roma, , Italy
Ospedale SS Trinita, Sora (FR), , Italy
Aichi Cancer Center Hospital, Nagoya, Aichi, Japan
National Cancer Center Hospital East, Kashiwa, Chiba, Japan
National Hospital Organization Shikoku Cancer Center, Matsuyama-city, Ehime, Japan
National Hospital Organization Hokkaido Cancer Center, Sapporo, Hokkaido, Japan
Kumamoto City Hospital, Kumamoto-shi, Kumamoto, Japan
Saitama Cancer Center, Kita-adachi-gun, Saitama, Japan
National Cancer Center Hospital, Chuo-Ku, Tokyo, Japan
Chiba Cancer Center, Chiba, , Japan
National Hospital Organization Kyushu Cancer Center, Fukuoka, , Japan
Hiroshima City Hiroshima Citizens Hospital, Hiroshima, , Japan
Iwate Medical University Hospital, Iwate, , Japan
Hakuaikai Medical Corporation Sagara Hospital, Kagoshima, , Japan
Kumamoto University Hospital, Kumamoto, , Japan
Niigata Cancer Center Hospital 2-15-3, Niigata, , Japan
National Hospital Organization Osaka National Hospital, Osaka, , Japan
National Cancer Center, Center for Breast Cancer, Goyang-si, Gyeonggi-do, Korea, Republic of
Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, Korea, Republic of
Severance Hospital, Yonsei University Health System, Seodaemun-gu, Seoul, Korea, Republic of
Seoul National University Hospital / Department of Internal Medicine, Seoul, , Korea, Republic of
Asan Medical Center, Division of Oncology, Department of Internal Medicine, Seoul, , Korea, Republic of
Samsung Medical Center, Division of Hematology-Oncology, Department of Medicine, Seoul, , Korea, Republic of
Europejskie Centrum Zdrowia Otwock, Otwock, Mazovia, Poland
Oncology and Radiotherapy Clinic, Gdańsk, , Poland
Niepubliczny Zakład Opieki Zdrowotnej "Onko-Dent" SP.P. G.L. Słomian, Zory, , Poland
Regional Budgetary Healthcare Institution Kursk Regional Clinical, Kursk, Kursk Region, Russian Federation
State Budget Healthcate Institution "Leningrad Region Oncology Dispensary", Kuzmolovo, Leningrad Region, Russian Federation
GUZ Republic Clinical Oncology Dispensary of Ministry of Health of Republic of Tatarstan, Kazan, , Russian Federation
State Budget Healthcare Institution Moscow City Oncology Hospital, Moscow Area, , Russian Federation
Federal State Budget Institution, Moscow, , Russian Federation
Budget Institution of Healthcare, Omsk, , Russian Federation
Budget Institution of Healthcare, Omsk, , Russian Federation
Ryazan Regional Clinical Oncology Dispensary, Ryazan, , Russian Federation
Saint-Petersburg State Budget Healthcare Institution (SBHCI), Saint-Petersburg, , Russian Federation
Non-State Health Care agency "Road Clinical Hospital of PLC" Russian Railways, St Petersburg, , Russian Federation
Republican Clinical Hospital n.a. G.G. Kuvatov, Ufa, , Russian Federation
State Budget Medical Institution Republican Clinical Oncology, Ufa, , Russian Federation
SBHI of Republic of Bashkortostan Emergency Hospital, Ufa, , Russian Federation
Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain
Consorci Sanitari de Terrassa, Terrassa, Barcelona, Spain
Hospital Universitari Son Espases, Palma de Mallorca, Islas Baleares, Spain
Hospital Universitario Fundacion de Alcorcon, Alcorcon, Madrid, Spain
Hospital Universitario de Canarias, La Laguna, Santa CRUZ DE Tenerife, Spain
Hospital Universitario Infanta Cristina, Badajoz, , Spain
Hospital del Mar, Barcelona, , Spain
Hospital Universitari Vall d'Hebron, Barcelona, , Spain
Hospital Clinic I Provincial, Barcelona, , Spain
Hospital de Donostia, Donostia- San Sebastian, , Spain
Complejo Hospitalario de Jaen, Jaen, , Spain
Instituto Catalan de Oncologia L'Hospitalet, L'Hospitalet De Llobregat (Barcelona), , Spain
Centro Oncologico de Galicia, La Coruna, , Spain
Hospital Universitario Arnau de Vilanova de Lleida, Lleida, , Spain
Hospital General Universitario Gregorio Marañon, Madrid, , Spain
Centro Oncologico MD Anderson Internacional España, Madrid, , Spain
Hospital Clinico San Carlos, Madrid, , Spain
HOSPITAL Universitario 12 DE OCTUBRE, Madrid, , Spain
Hospital Madrid Universitario Sanchinarro, Madrid, , Spain
Hospital Universitario Virgen Macarena, Sevilla, , Spain
Hospital Universitario Virgen del Rocio, Sevilla, , Spain
Instituto Valenciano de Oncologia, Valencia, , Spain
National Taiwan University Hospital, Taipei City, , Taiwan
Veterans General Hospital-Taipei, Taipei City, , Taiwan
Mackay Memory Hospital, Taipei, , Taiwan
MI "Dnipropetrovsk City Multidisciplinary Clinical Hospital No.4" of the Dnipropetrovsk City Council, Dnipro, , Ukraine
State Institution Dnipropetrovsk Medical Academy at the Ministry of Health of Ukraine, Dnipro, , Ukraine
Municipal Non-profit Enterprise "Regional Centre of Oncology", Kharkiv, , Ukraine
Lviv State Oncologic Regional Treatment and Diagnostic Center, Chemotherapy Department, Lviv, , Ukraine
Municipal Medical Institution "Makiivka City Hospital No.2 of Donetsk Region", Makiivka, , Ukraine
Regional Municipal Establishment "Sumy Regional Clinical Oncology Dispensary", Thoracic Department, Sumy, , Ukraine
City Oncology Centre of Central Municipal Clinical Hospital, Uzhgorod, , Ukraine
Institute of Postgraduate education and preuniversity preparing of Uzhgorod National Univ., Uzhgorod, , Ukraine
MI "Zaporizhzhia Regional Clinical Oncology Dispensary" Zaporizhzhia Regional Assembly,, Zaporizhzhia, , Ukraine
State institution "Zaporizhzhia Medical Academy of Postgraduate Education MOH Ukraine",, Zaporizhzhya, , Ukraine
Kent Oncology Center, Maidstone, Kent, United Kingdom
Edinburgh Cancer Centre, Western General Hospital, Edinburgh, Scotland, United Kingdom
Beatson Institute for Cancer Research, Glasgow, Scotland, United Kingdom
Guys Hospital, London, , United Kingdom
The Royal Marsden NHS Foundation Trust, London, , United Kingdom
Charing Cross Hospital, London, , United Kingdom
Christie Hospital NHS Foundation Trust, Manchester, , United Kingdom
The Research And Development Office, The Christie NHS Foundation Trust, Manchester, , United Kingdom
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