Spots Global Cancer Trial Database for Pilot Study of Bisphosphonates for Breast Cancer
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Trial Identification
Brief Title: Pilot Study of Bisphosphonates for Breast Cancer
Official Title: Pilot Clinical Trial of Short-Term Bisphosphonate Administration as Chemoprevention for Breast Cancer Via Engagement of γδ T Cells
Study ID: NCT02781805
Conditions
Interventions
Study Description
Brief Summary: The goal of this study is to mechanistically define the potential anticancer activities of the osteoporosis bisphosphonate (BP) drug alendronate, and extend the analysis to learn novel information about the impact of BP on gamma delta (γδ) T cells in breast tissues as well as epithelial breast cell differentiation of high-risk women. To this end, we have designed a BP "window trial" to examine the effect of 1 - 3 weeks administration of alendronate on women at high-risk for breast cancer, at the level of immunosurveillance and mammary epithelial cell differentiation.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: FEMALE
Healthy Volunteers: Yes
Locations
University of Wisconsin Carbone Cancer Center, Madison, Wisconsin, United States
Contact Details
Name: Lee Wilke
Affiliation: University of Wisconsin, Madison
Role: PRINCIPAL_INVESTIGATOR
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