Spots Global Cancer Trial Database for Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
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Trial Identification
Brief Title: Study of Cytochrome P450 Polymorphisms (CYP2D6, CYP3A4/5 and CYP2C19) in Breast Cancer Patients
Official Title: Association Between Genetic Polymorphisms of CYP2D6 and Outcomes in Breast Cancer Patients With Tamoxifen Treatment
Study ID: NCT01169792
Interventions
Study Description
Brief Summary: The genetic polymorphisms of the cytochrome P450 may influence on the metabolism of tamoxifen. The investigators want to * evaluate the frequency or incidence of the genetic polymorphisms of cytochrome P450 subfamilies(CYP2D6, CYP3A4/5 and CYP2C19) in breast cancer patients, and * analyze the association between the genetic polymorphisms of cytochrome P450 subfamilies and clinical outcomes in breast cancer patients treated by adjuvant tamoxifen therapy.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine, Jin-Gu, Busan, Korea, Republic of
Department of Surgery, Yonsei University College of Medicine, Saedaemoon-gu, Seoul, Korea, Republic of
Contact Details
Name: Byeong-Woo Park, M.D.,ph.D.
Affiliation: Department of Surgery and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine
Role: STUDY_CHAIR
Name: Jae-Gook Shin, M.D.,ph.D.
Affiliation: Department of Pharmacology and Pharmacogenomics Research Center, Inje University College of Medicine
Role: STUDY_CHAIR
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