Spots Global Cancer Trial Database for Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer

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Trial Identification

Brief Title: Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer

Official Title: Analysis of the Impact of 5-Fluorouracil on the Translational Control and Plasticity of Cancer Cells From Liver Metastases of Colon Cancer

Study ID: NCT04274790

Conditions

Cancer of Colon

Metastasis to Liver

Interventions

Scheduled and planned surgery

Study Description

Brief Summary: Analyze the dynamics of incorporation of 5-fluorouracil into cancer cell ribosomes from liver metastases of patient with metastatic colon cancer.

Detailed Description: This is a monocentric, prospective, non-interventional cohort study in adult patients with metastatic colon cancer with hepatics metastasis. Tumour samples collected for this study include: * A fragment of the previously operated primary tumor: FFIP block and/or archived frozen tumor if available. * A fragment of the liver metastasis(s) performed as part of standard metastasis surgery, this fragment will include a tumor area and a healthy area within the margin of excision. These samples collected in a fresh state will be analyzed immediately.