Spots Global Cancer Trial Database for The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients

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Trial Identification

Brief Title: The Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients

Official Title: A Phase II Study of the Effects of Physical Activity and Low-Dose Ibuprofen on Cognitive Function in Cancer Patients Undergoing Chemotherapy

Study ID: NCT01238120

Conditions

Cancer-related Cognitive Difficulties

Interventions

Ibuprofen

Home-Based Exercise

Placebo

Study Description

Brief Summary: This research seeks to determine if a combination of low-dose ibuprofen along with a structured home-based walking and progressive resistance exercise program, EXCAP, will be effective in reducing cognitive difficulties among cancer patients receiving chemotherapy.

Detailed Description: To conduct a feasibility pilot to assess preliminary efficacy of a 6 week course of ibuprofen (200 mg BID with does 8 hours apart) and a structured home based walking/progressive resistance program, EXCAP, alone or together, on cognitive function and levels of inflammatory molecules among cancer patients receiving chemotherapy (beginning at cycle 2). If these interventions prove to be useful and have potential benefit, they could have a substantial impact on treating cognitive difficulties experienced by cancer patients as well as improve quality of life. Moreover, if there is an effect of these interventions on cognitive functioning and inflammation, we will gain more knowledge of a possible mechanism of chemotherapy-related cognitive difficulties.