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Spots Global Cancer Trial Database for SC-004 Alone or With ABBV-181 in Subjects With Epithelial Ovarian, Fallopian Tube, Primary Peritoneal and Endometrial Cancers

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Trial Identification

Brief Title: SC-004 Alone or With ABBV-181 in Subjects With Epithelial Ovarian, Fallopian Tube, Primary Peritoneal and Endometrial Cancers

Official Title: An Open Label, Phase 1 Study of SC-004 as Monotherapy and in Combination With ABBV-181 in Subjects With Epithelial Ovarian, Including Fallopian Tube and Primary Peritoneal and Endometrial Cancers

Study ID: NCT03138408

Conditions

Cancer

Interventions

SC-004
ABBV-181

Study Description

Brief Summary: This is a two-part study consisting of Part A (dose regimen finding) followed by Part B (dose expansion). Part A (dose regimen finding) will allow definition of the maximum tolerated dose (MTD) through dose escalation and possible dose interval modification. In Part B (dose expansion), potential therapeutic doses may be studied with SC-004 as monotherapy and SC-004 in combination with ABBV-181 in disease-specific cohorts.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: FEMALE

Healthy Volunteers: No

Locations

University of Alabama /ID# 202249, Birmingham, Alabama, United States

Highlands Oncology Group /ID# 209165, Fayetteville, Arkansas, United States

City of Hope /ID# 202493, Duarte, California, United States

University of Chicago /ID# 200735, Chicago, Illinois, United States

Henry Ford Health System /ID# 202480, Detroit, Michigan, United States

Mayo Clinic - Rochester /ID# 200732, Rochester, Minnesota, United States

Washington University School /ID# 164091, Saint Louis, Missouri, United States

The Ohio State University - Columbus /ID# 164089, Columbus, Ohio, United States

Univ Oklahoma HSC /ID# 164090, Oklahoma City, Oklahoma, United States

Tennessee Oncology-Nashville Centennial /ID# 164088, Nashville, Tennessee, United States

MD Anderson Cancer Center /ID# 200048, Houston, Texas, United States

Huntsman Cancer Institute /ID# 209164, Salt Lake City, Utah, United States

Contact Details

Name: AbbVie Inc.

Affiliation: AbbVie

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

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