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Brief Title: A Study of Radiation With Sorafenib in Advanced Cancer
Official Title: A Phase I Dose Escalation Study of Concurrent Low Dose Radiation With Sorafenib in Three Anatomically-based Independent Cohorts (Thorax, Abdomen, Pelvis)
Study ID: NCT00610246
Brief Summary: The purpose of this study is to test the combination of radiation treatment and an anti-angiogenic drug called sorafenib (or BAY 43-9006 or Nexavar) to determine the effects of this combination on cancers but also on side effects of radiation treatment. This study will also determine the highest safe dose of sorafenib that can be given with radiation treatment.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Princess Margaret Hospital, Toronto, Ontario, Canada
Name: Anthony Brade
Affiliation: Princess Margaret Hospital, Canada
Role: PRINCIPAL_INVESTIGATOR