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Brief Title: Corticosteroids for Cancer Pain
Official Title: Corticosteroids for Cancer Pain
Study ID: NCT00676936
Brief Summary: Study hypothesis: corticosteroids are effective for pain in cancer patients. We will perform a double-blind, randomized, placebo-controlled multicentre trial evaluating the effect of Methylprednisolone 16 mg twice daily in cancer patients with pain (average pain last 24 hrs NRS \> 4 (Numerical rating scale, 0 No pain, 10 worst pain).
Detailed Description: Patients are required to use strong opioids before entering the study. Weak opioids are allowed if patients have short acting strong opioids as rescue-medication. The scheduled opioids shall be stable last 48 hours before entering the study and will be kept stable during the study period. Patients may use as much short acting rescue-medication as they require. No other analgesic medication should be started during the study period. The study is a multicentre trial. Patients will be randomized according to 1. study centre (No 1-5) and 2. pain mechanism: skeletal metastases (yes/no). Patients are evaluated Day 0 and Day 7 by palliative care physician. Patients will be contacted by phone Day 1-6 and will fill in questionnaire regarding symptoms and analgesic usage. Patients will be contacted Day 14 and 21 to fill in questionnaires regarding symptoms, quality of life and side effects.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Haraldsplass Diakonale sykehus, Bergen, , Norway
Sykehuset Buskerud HF, Drammen, , Norway
Sørlandet Sykehus HF, Kristiansand, , Norway
Oslo Universitetssykehus, Ulleval, Oslo, , Norway
Sykehuset Telemark HF, Skien, , Norway
St Olavs Hospital HF, Trondheim, , Norway
Name: Stein Kaasa, MD PhD prof
Affiliation: Norwegian University of Science and Technology
Role: STUDY_DIRECTOR