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Brief Title: Safety Study of MPC-3100 in Cancer Patients Who Have Failed Other Treatments
Official Title: Phase 1 Study of MCP-3100 in Patients With Refractory or Relapsed Cancer
Study ID: NCT00920205
Brief Summary: The purpose of this study is to see how safe the study drug is and to determine the best dose to use in cancer patients in the future. The study drug is designed to reduce the activity of a protein known as "heat shock protein 90", or "Hsp90". Hsp90 is found in every cell in the human body and normally helps those cells (and the body) cope with stressful situations. In certain cancers, however, Hsp90 helps the cancer cells survive and grow. By reducing the activity of Hsp90, the study drug may slow the growth, and reduce the survival, of those cancer cells.
Detailed Description: This is a dose escalation study. As subjects participating in the study tolerate a specific dose level, the new subjects entering will be given a higher dose of the study drug.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Nevada Cancer Institute, Las Vegas, Nevada, United States
Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States
South Texas Accelerated Research Therapeutics, San Antonio, Texas, United States
Name: Andrew Beelen, MD
Affiliation: Myrexis Inc.
Role: STUDY_DIRECTOR