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Spots Global Cancer Trial Database for Safety and Tolerability Study of GSK1120212, a MEK Inhibitor, in Combination With Docetaxel, Erlotinib, Pemetrexed, Pemetrexed + Carboplatin, Pemetrexed + Cisplatin, or Nab-Paclitaxel

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Trial Identification

Brief Title: Safety and Tolerability Study of GSK1120212, a MEK Inhibitor, in Combination With Docetaxel, Erlotinib, Pemetrexed, Pemetrexed + Carboplatin, Pemetrexed + Cisplatin, or Nab-Paclitaxel

Official Title: An Open-Label, Phase I/Ib Dose Escalation Study to Assess the Safety and Tolerability of GSK1120212 in Combination With Docetaxel, Erlotinib, Pemetrexed, Pemetrexed + Carboplatin, Pemetrexed + Cisplatin, or Nab-Paclitaxel in Subjects With Advanced Solid Tumors

Study ID: NCT01192165

Conditions

Cancer

Study Description

Brief Summary: The purpose of this study is to determine what dose of GSK1120212 can be given safely in combination with at least one other drug that is already approved to treat cancer. This study will test the safety of up to 6 different GSK1120212 study treatment combinations (GSK1120212 plus either docetaxel, erlotinib, pemetrexed, pemetrexed + carboplatin, pemetrexed + cisplatin, or nab-paclitaxel). The doses identified in this study may be used in future trials to test whether the combination treatment is a safe and effective therapy for subjects with metastatic lung and/or pancreatic cancers.

Detailed Description:

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

GSK Investigational Site, Scottsdale, Arizona, United States

GSK Investigational Site, Duarte, California, United States

GSK Investigational Site, Sacramento, California, United States

GSK Investigational Site, Denver, Colorado, United States

GSK Investigational Site, Las Vegas, Nevada, United States

GSK Investigational Site, Albany, New York, United States

GSK Investigational Site, Greenville, South Carolina, United States

GSK Investigational Site, Nashville, Tennessee, United States

GSK Investigational Site, Dallas, Texas, United States

GSK Investigational Site, Houston, Texas, United States

GSK Investigational Site, Tyler, Texas, United States

GSK Investigational Site, Norfolk, Virginia, United States

GSK Investigational Site, Vancouver, Washington, United States

GSK Investigational Site, Toronto, Ontario, Canada

GSK Investigational Site, Caen Cedex 9, , France

GSK Investigational Site, Marseille cedex 5, , France

GSK Investigational Site, Saint-Herblain cedex, , France

GSK Investigational Site, Toulouse cedex, , France

GSK Investigational Site, Seoul, , Korea, Republic of

GSK Investigational Site, Seoul, , Korea, Republic of

Contact Details

Name: GSK Clinical Trials

Affiliation: GlaxoSmithKline

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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