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Spots Global Cancer Trial Database for Study of Pemetrexed and Bevacizumab in Patients With Head and Neck Cancer

The following info and data is provided "as is" to help patients around the globe.
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Trial Identification

Brief Title: Study of Pemetrexed and Bevacizumab in Patients With Head and Neck Cancer

Official Title: Phase II Trial of Pemetrexed and Bevacizumab in Patients With Recurrent or Metastatic Head and Neck Cancer

Study ID: NCT00222729

Conditions

Cancer

Study Description

Brief Summary: The purpose of this study is to determine if the combination of two new drugs pemetrexed (Alimta) and bevacizumab (Avastin) can increase the effectiveness of treatment for head and neck cancer. Currently pemetrexed is approved by the Food and Drug Administration (FDA) for another type of cancer, mesothelioma, but it is not approved for head and neck cancer.

Detailed Description: Main objectives of this study are to 1) evaluate the time to progression (primary endpoint) with the combination of pemetrexed and bevacizumab in recurrent or metastatic head and neck cancer; 2) evaluate the objective response rate, duration of response, overall survival, and toxicities associated with the above therapy and 3) collect tumor tissue from previous diagnostic procedures and blood specimens prospectively, before and after therapy, for future correlative studies.

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hillman Cancer Center, Pittsburgh, Pennsylvania, United States

Contact Details

Name: Julie Bauman, MD

Affiliation: University of Pittsburgh

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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