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Spots Global Cancer Trial Database for Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood

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Trial Identification

Brief Title: Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood

Official Title: Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood. Ancillary Study of the "Long-term Follow-up of Childhood Cancer Survivors in the Rh么ne-Alpes and Auvergne Regions of France" Study

Study ID: NCT01574196

Study Description

Brief Summary: The SALTO-SNA study is an ancillary study of the SALTO study (Suivi 脌 Long Terme en Oncologie des enfants gu茅ris d'un cancer p茅diatrique en r茅gions Rh么ne-Alpes et Auvergne) coordinated by Dr. Claire Berger, pediatric oncologist at the CHU, Saint Etienne. It aims at re-examining, in their initial treatment center, all patients (a cohort of 495 patients alive in 2011), diagnosed between 1987 and 1992, and cured of childhood cancer (except leukemia) in the Rh么ne-Alpes and Auvergne regions. The rationale for this study is based on the observation that although the survival rate of childhood cancers has now reached 75%, complications of chemotherapy and radiotherapy are high and greatly increase the risk of mortality in later years (estimated to be 14% in the literature). The morbidity risk of chemotherapy and radiotherapy can be quantified by assessing the activity of the intrinsic cardiac autonomic regulation, which represents a powerful predictor of cardiovascular morbidity to the individual.

Detailed Description: For this purpose, analysis of the cardiac RR variability is a reliable, non-invasive and reproducible system that could be used in this population as a tool for early detection of cardiovascular dysfunction.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CHU de Clermont-Ferrand, Clermont-ferrand, , France

CHU de Grenoble, Grenoble, , France

IHOP, Lyon, , France

CHU de Saint-Etienne, Saint-etienne, , France

Contact Details

Name: Claire BERGER, MD

Affiliation: CHU de Saint-Etienne

Role: PRINCIPAL_INVESTIGATOR

Name: Hugues PATURAL, MD PhD

Affiliation: CHU de Saint-Etienne

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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