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Brief Title: Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood
Official Title: Assessment of Cardiac Autonomic Function in Adulthood After Chemotherapy or Radiotherapy in Childhood. Ancillary Study of the "Long-term Follow-up of Childhood Cancer Survivors in the Rh么ne-Alpes and Auvergne Regions of France" Study
Study ID: NCT01574196
Brief Summary: The SALTO-SNA study is an ancillary study of the SALTO study (Suivi 脌 Long Terme en Oncologie des enfants gu茅ris d'un cancer p茅diatrique en r茅gions Rh么ne-Alpes et Auvergne) coordinated by Dr. Claire Berger, pediatric oncologist at the CHU, Saint Etienne. It aims at re-examining, in their initial treatment center, all patients (a cohort of 495 patients alive in 2011), diagnosed between 1987 and 1992, and cured of childhood cancer (except leukemia) in the Rh么ne-Alpes and Auvergne regions. The rationale for this study is based on the observation that although the survival rate of childhood cancers has now reached 75%, complications of chemotherapy and radiotherapy are high and greatly increase the risk of mortality in later years (estimated to be 14% in the literature). The morbidity risk of chemotherapy and radiotherapy can be quantified by assessing the activity of the intrinsic cardiac autonomic regulation, which represents a powerful predictor of cardiovascular morbidity to the individual.
Detailed Description: For this purpose, analysis of the cardiac RR variability is a reliable, non-invasive and reproducible system that could be used in this population as a tool for early detection of cardiovascular dysfunction.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
CHU de Clermont-Ferrand, Clermont-ferrand, , France
CHU de Grenoble, Grenoble, , France
IHOP, Lyon, , France
CHU de Saint-Etienne, Saint-etienne, , France
Name: Claire BERGER, MD
Affiliation: CHU de Saint-Etienne
Role: PRINCIPAL_INVESTIGATOR
Name: Hugues PATURAL, MD PhD
Affiliation: CHU de Saint-Etienne
Role: STUDY_DIRECTOR