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Spots Global Cancer Trial Database for Exome Analysis (Complexe vs Simple) to Help the Therapeutic Decision for the Precision Medicine

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Trial Identification

Brief Title: Exome Analysis (Complexe vs Simple) to Help the Therapeutic Decision for the Precision Medicine

Official Title: A Multicenter, Prospective, Multi-organ Study to Evaluate the Clinical Benefit of an Exome "Complex" Analysis Versus an Exome "Simple" Analysis to Help the Therapeutic Decision for the Precision Medicine

Study ID: NCT04614480

Conditions

Cancer

Interventions

Exome analysis

Study Description

Brief Summary: The "simple" analysis of the exome can determine somatic and constitutional mutations. The major challenge lies in the translation of sequencing data into clinically relevant information allowing the clinician to guide his decision-making A "complex" analysis of the exome would provide access to structural DNA data, concerning mutational signatures, tumor mutational load, analysis of large deletions, loss of heterozygosity as well as amplification of certain genes which may have an impact on the management of patients. No data available to date makes it possible to assess the clinical interest of the availability of its additional information resulting from a "complex" analysis compared to a "simple" analysis. The objective of the EXOMA2 study is to assess the proportion of patients for whom the proposed therapy is derived from its additional information (complex analysis) and would not have been possible with a classic exome analysis (simple analysis) . We hereby formulate the hypothesis that a "complex" analysis on a population presenting a metastatic or locally advanced disease treated early (from the 1st line of treatment) will make it possible to determine therapeutic indications which could not be discovered with a "simple" analysis.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

CHU Amiens Picardie, Amiens, , France

CHRU Jean Minjoz, Besançon, , France

Institut Bergonie, Bordeaux, , France

CGFL, Dijon, , France

CHU François Mitterrand, Dijon, , France

Institut Hospitalier Franco-Britannique, Levallois-perret, , France

Centre Oscar Lambret, Lille, , France

CHU Nantes, Nantes, , France

Chu Poitiers, Poitiers, , France

Contact Details

Name: Charles Coutant, PU-PH

Affiliation: Centre Georges François Leclerc

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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