Spots Global Cancer Trial Database for The Gut Immune System During Immune Checkpoint Inhibitor Therapy
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Trial Identification
Brief Title: The Gut Immune System During Immune Checkpoint Inhibitor Therapy
Official Title: Deep Phenotyping of the Gut Immune System During Immune Checkpoint Inhibitor Therapy - DEFENCE
Study ID: NCT04600180
Conditions
Interventions
Study Description
Brief Summary: This exploratory study aims to gain insight in gut immune system phenotypes before and after immunotherapy. After informed consent is obtained, sigmoidoscopies at baseline and during treatment with immunotherapy will be performed, During the endoscopies, biopsies from the sigmoid and rectum will be obtained. Subsequent immune cell analyses in these biopsies will be performed. Parallel to the sigmoidoscopies, venous blood samples will be obtained to monitor inflammatory markers.
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University Medical Center Groningen, Groningen, , Netherlands
Contact Details
Name: Jacco J. de Haan, MD, PhD
Affiliation: University Medical Center Groningen
Role: PRINCIPAL_INVESTIGATOR
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