Spots Global Cancer Trial Database for A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

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Trial Identification

Brief Title: A Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

Official Title: A Pilot Randomized Trial of a Mobile Health Exercise Intervention for Older Adults With Myeloid Neoplasms

Study ID: NCT04981821

Conditions

Cancer

Myeloid Neoplasm

Interventions

GO-EXCAP Mobile App

Behavioral Placebo Control

Study Description

Brief Summary: This is a phase 2 randomized controlled trial (RCT) to assess the preliminary efficacy of the a mobile health exercise intervention (GO-EXCAP) versus a chemotherapy education control in 100 older patients with MN receiving outpatient chemotherapy on physical function and patient-reported outcomes (fatigue, mood, and quality of life). We will also explore the effect of the intervention on TNFα and related cytokine gene promoter methylation and their gene and protein expression.

Detailed Description: Up to 98% of older patients with myeloid neoplasms experience physical function decline, fatigue, and mood disturbances. Mobile health exercise interventions are promising strategy to prevent physical function decline and improve fatigue and mood disturbances, but older patients with myeloid neoplasms receiving outpatient chemotherapy are understudied. The proposed study will investigate whether a novel mobile health exercise intervention that is adapted to this population can prevent physical function decline, improve fatigue and mood disturbances, and prevent worsening quality of life.