Spots Global Cancer Trial Database for Childhood Cancer Survivor Study
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Trial Identification
Brief Title: Childhood Cancer Survivor Study
Official Title: Childhood Cancer Survivor Study
Study ID: NCT01120353
Conditions
Interventions
Study Description
Brief Summary: The Childhood Cancer Survivor Study (CCSS) will investigate the long-term effects of cancer and its associated therapies. A retrospective cohort study will be conducted through a multi-institutional collaboration, which will involve the identification and active follow-up of a cohort of approximately 50,000 survivors of cancer, diagnosed before 21 years of age, between 1970 and 1999 and 10,000 sibling controls. This project will study children and young adults exposed to specific therapeutic modalities, including radiation, chemotherapy, and/or surgery, who are at increased risk of late-occurring adverse health outcomes. A group of sibling controls will be identified and data collected for comparison purposes.
Detailed Description: The study will focus on the following objectives: * Characterize survivors' health with respect to disease- and treatment-related factors. * Investigate the consequences of various intensities of exposure to chemotherapy and/or radiation on health outcomes (e.g., cardiovascular, reproductive, second cancers, etc...). * Compare the mortality experience of survivors with the general population. * Characterize the health-related behaviors, patterns of medical care, and medical follow-up needs of survivors. * Describe patterns of familial aggregation of cancer, including known (and variations of) cancer family syndromes. * Collect and store biologic samples (saliva, blood, second tumor tissue) to correlate with health outcomes and use for future research.
Eligibility
Minimum Age:
Eligible Ages: CHILD, ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: Yes
Locations
University of Alabama at Birmingham/Children's of Alabama, Birmingham, Alabama, United States
City of Hope National Medical Center, Duarte, California, United States
Children's Hospital Los Angeles, Los Angeles, California, United States
University of California-Los Angeles, Los Angeles, California, United States
Children's Hospital of Orange County, Orange, California, United States
University of California-San Francisco, San Francisco, California, United States
Stanford University School of Medicine, Stanford, California, United States
Children's Hospital Colorado, Aurora, Colorado, United States
Children's National Medical Center, Washington, District of Columbia, United States
Emory University/Children's Health Care of Atlanta, Atlanta, Georgia, United States
Ana & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States
University of Chicago, Chicago, Illinois, United States
Indiana University/Riley Hospital for Children, Indianapolis, Indiana, United States
Dana-Farber Cancer Institute, Boston, Massachusetts, United States
University of Michigan/Mott Children's Hospital, Ann Arbor, Michigan, United States
Children's Hospitals & Clinics of Minnesota, Minneapolis, Minnesota, United States
University of Minnesota, Minneapolis, Minnesota, United States
Mayo Clinic, Rochester, Minnesota, United States
St. Louis Children's Hospital/The Washington University, Saint Louis, Missouri, United States
Roswell Park Cancer Institute, Buffalo, New York, United States
Memorial-Sloan Kettering Cancer Center, New York, New York, United States
Nationwide Children's Hospital, Columbus, Ohio, United States
Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States
Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, United States
St. Jude Children's Research Hospital, Memphis, Tennessee, United States
University of Texas Southwestern Medical Center, Dallas, Texas, United States
Cook Children's Medical Center, Fort Worth, Texas, United States
M.D. Anderson Cancer Center, Houston, Texas, United States
Texas Children's Hospital, Houston, Texas, United States
Seattle Children's Hospital, Seattle, Washington, United States
The Hospital for Sick Children, Toronto, Ontario, Canada
Contact Details
Name: Gregory T. Armstrong, MD, MSCE
Affiliation: St. Jude Children's Research Hospital
Role: PRINCIPAL_INVESTIGATOR
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