Spots Global Cancer Trial Database for Bladder and Bone Effects of Pelvic Radiation Therapy in Childhood Cancer Survivors

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Trial Identification

Brief Title: Bladder and Bone Effects of Pelvic Radiation Therapy in Childhood Cancer Survivors

Official Title: Effect of Pelvic Radiation Therapy on the Urinary and Musculoskeletal Systems of Survivors of Childhood Cancer

Study ID: NCT05818462

Conditions

Cancer

Childhood Cancer

Interventions

Uroflow testing

Bladder Scan

Dysfunctional Voiding Scoring System Survey

DEXA Scan of pelvis and sacral spine

Urine tests for specific biomarkers

Study Description

Brief Summary: The aim of this study is to measure and evaluate the effects of pelvic external beam radiation therapy (EBRT) on lower urinary tract (LUT) function and bone mineralization.

Detailed Description: The aim of this study is to measure and evaluate the effects of pelvic external beam radiation therapy (EBRT) on lower urinary tract (LUT) function and bone mineralization. The overarching hypothesis is that patients who received EBRT to the pelvis will have an increased rate of LUT dysfunction and osteoporosis even when controlled for chemotherapeutic exposures, using patients with similar chemotherapy regimens as controls. Between these two groups, the team expect to observe significant differences in both patient-reported outcomes and direct measures of LUT function.