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Spots Global Cancer Trial Database for Effects of Serotonin Excess on Bone in Carcinoid Syndrome

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Trial Identification

Brief Title: Effects of Serotonin Excess on Bone in Carcinoid Syndrome

Official Title: Effects of Serotonin Excess on Bone in Carcinoid Syndrome

Study ID: NCT01430871

Interventions

Study Description

Brief Summary: Serotonin has recently been identified as a major regulator of bone formation. Gut-derived serotonin inhibits bone formation, and early animal studies have shown that inhibition of gut-derived serotonin has anabolic effects on bone in ovariectomised rodents. This pathway has potential to be developed as a new anabolic treatment for osteoporosis in humans. Carcinoid neuro-endocrine tumours produce very high levels of serotonin, and so it might be expected that patients with carcinoid disease would have reduced bone formation, low bone mass and fractures. However, this has not been apparent in clinical practice. There may be a discrepancy between rodent models and human disease. This study aims to identify whether patients with carcinoid disease have reduced bone mass, reduced bone formation or high fracture rates. The investigators will conduct a cross-sectional observational case-control study of patients with carcinoid disease in the Sheffield neuro-endocrine tumour clinic and gender-, age- and body mass index (BMI)-matched controls.

Detailed Description:

Keywords

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: Yes

Locations

Academic Unit of Bone Metabolism (Sheffield), Sheffield, South Yorks, United Kingdom

Contact Details

Name: Jennifer S Walsh, PhD

Affiliation: Sheffield Teaching Hospitals NHS Foundation Trust

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

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