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Spots Global Cancer Trial Database for Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features

The following info and data is provided "as is" to help patients around the globe.
We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Safety Study of Seneca Valley Virus in Patients With Solid Tumors With Neuroendocrine Features

Official Title: Phase I Dose-Escalation Study of Seneca Valley Virus (SVV-001), a Replication-Competent Picornavirus, in Patients With Advanced Solid Tumors With Neuroendocrine Features

Study ID: NCT00314925

Study Description

Brief Summary: The primary purpose of the study is to determine if Seneca Valley Virus may be administered safely to patients with certain types of advanced cancer.

Detailed Description: This is the first study in man of Seneca Valley Virus, a virus which seeks and kills certain tumors in non-human model systems. Subjects in this trial will be patients with advanced cancer displaying certain specified neuroendocrine features, pathologically; they will have exhausted standard methods of treatment for their tumor. The primary purpose of the trial is to determine if the virus may be administered safely. Additional purposes are to learn about the distribution of the virus in the body, the elimination of the virus from the body, the immune response to the virus and whether the virus might have some beneficial effects upon the tumors which the patients have. The first patients will be treated with low amounts of virus and subsequent patients may receive higher amounts. At the end of the trial, it is intended to select a dose for further study.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Cancer Centers of Florida, Ocoee, Florida, United States

Central Indiana Cancer Centers, Indianapolis, Indiana, United States

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland, United States

New York Oncology Hematology P.C., Albany, New York, United States

Dayton Oncology & Hematology, P.A ., Kettering, Ohio, United States

Cancer Centers of the Carolinas, Greenville, South Carolina, United States

Mary Crowley Research Center, Dallas, Texas, United States

Tyler Cancer Center, Tyler, Texas, United States

Virginia Oncology Associates, Norfolk, Virginia, United States

Northwest Cancer Specialists - Vancouver Cancer Center, Vancouver, Washington, United States

Contact Details

Name: Rudin Charles, MD, PhD

Affiliation: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Role: STUDY_CHAIR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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