Spots Global Cancer Trial Database for Efficacy Study of TACE to Treat Hepatocellular Carcinoma After Operation
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Trial Identification
Brief Title: Efficacy Study of TACE to Treat Hepatocellular Carcinoma After Operation
Official Title: Post-hepatectomy Adjuvant Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma Patients With Preoperative CTC Level ≥2: a Multicenter Randomized Controlled Trial in China
Study ID: NCT02631499
Study Description
Brief Summary: This study is designed to prospectively evaluate whether post-hepatectomy adjuvant transcatheter arterial chemoembolization (TACE) is effective in reducing early recurrence in HCC patients with preoperative CTC ≥2.
Detailed Description: Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies worldwide, and associated morbidity and mortality rates have escalated in recent years. Despite improvements in surveillance and clinical treatment strategies, the prognosis of HCC remains very poor due to high incidence of recurrence and metastasis. Recent clinical studies have provided evidence that circulating tumor cell (CTC) may directly participate in the metastasis cascade in various types of malignancies. The investigators previous data indicated that HCC patients with preoperative CTC levels ≥2 suffered significantly earlier recurrence (within 1 year) than patients with lower levels. However, the benefits of postoperative adjuvant therapies in preventing early recurrence in patients with preoperative CTC ≥2 remain to be elucidated. Transarterial chemoembolisation (TACE) is an effective palliative treatment for HCC. The investigators design a randomised controlled trial evaluating the efficacy of using TACE after hepatectomy to reduce early recurrence rates in HCC patients with preoperative CTC level ≥2.
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China
Nantong Tumor Hospital, Nantong, Jiangsu, China
The First Affiliated Hospital of Soochow University, Soochow, Jiangsu, China
Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, Shanghai, China
Xinhua Hospital, Affliated with Shanghai Jiao Tong University, School of Medicine, Shanghai, Shanghai, China
Zhongshan hospital, Fudan University, Shanghai, Shanghai, China
Contact Details
Name: Jia Fan, MD & PhD
Affiliation: Shanghai Zhongshan Hospital, Fudan University
Role: PRINCIPAL_INVESTIGATOR
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