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Brief Title: Study of Regorafenib After Sorafenib in Patients With Hepatocellular Carcinoma
Official Title: A Randomized, Double Blind, Placebo Controlled, Multicenter Phase III Study of Regorafenib in Patients With Hepatocellular Carcinoma (HCC) After Sorafenib
Study ID: NCT01774344
Brief Summary: The objective of this study was to evaluate efficacy and safety of regorafenib in patients with advanced liver cancer who had progressed after sorafenib treatment. Patients were treated with regorafenib or placebo using a 2:1 randomization scheme.
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
, Los Angeles, California, United States
, Los Angeles, California, United States
, Orange, California, United States
, Aurora, Colorado, United States
, Washington, District of Columbia, United States
, Gainesville, Florida, United States
, Tampa, Florida, United States
, Chicago, Illinois, United States
, Louisville, Kentucky, United States
, Worcester, Massachusetts, United States
, Minneapolis, Minnesota, United States
, Saint Louis, Missouri, United States
, New York, New York, United States
, Rochester, New York, United States
, Pittsburgh, Pennsylvania, United States
, Richmond, Virginia, United States
, Seattle, Washington, United States
, Pilar, Buenos Aires, Argentina
, Camperdown, New South Wales, Australia
, Liverpool, New South Wales, Australia
, Herston, Queensland, Australia
, Clayton, Victoria, Australia
, Box Hill, , Australia
, Linz, Oberösterreich, Austria
, Graz, Steiermark, Austria
, Wien, , Austria
, Bruxelles - Brussel, , Belgium
, La Louviere, , Belgium
, Salvador, Bahia, Brazil
, Sao Paulo, , Brazil
, Hefei, Anhui, China
, Fuzhou, Fujian, China
, Guangzhou, Guangdong, China
, Guangzhou, Guangdong, China
, Guangzhou, Guangdong, China
, Nanning, Guangxi, China
, Harbin, Heilongjiang, China
, Wuhan, Hubei, China
, Changsha, Hunan, China
, Nanjing, Jiangsu, China
, Suzhou, Jiangsu, China
, Dalian, Liaoning, China
, Xi'an, Shaanxi, China
, Xi'an, Shaanxi, China
, Xi'an, Shaanxi, China
, Chengdu, Sichuan, China
, Beijing, , China
, Beijing, , China
, Beijing, , China
, Beijing, , China
, Chongqing, , China
, Shanghai, , China
, Shanghai, , China
, Shanghai, , China
, Tianjin, , China
, Hradec Kralove, , Czechia
, Olomouc, , Czechia
, Praha 2, , Czechia
, Angers, , France
, Caen, , France
, Clichy, , France
, Creteil, , France
, Dijon, , France
, La Tronche, , France
, Lille, , France
, Lyon, , France
, Marseille, , France
, Montpellier Cedex, , France
, Nice Cedex 3, , France
, Paris, , France
, Paris, , France
, Perpignan, , France
, Reims Cedex, , France
, Rennes Cedex, , France
, Toulouse, , France
, Vandoeuvre les Nancy, , France
, Villejuif Cedex, , France
, Heidelberg, Baden-Württemberg, Germany
, München, Bayern, Germany
, Frankfurt, Hessen, Germany
, Hannover, Niedersachsen, Germany
, Aachen, Nordrhein-Westfalen, Germany
, Essen, Nordrhein-Westfalen, Germany
, Köln, Nordrhein-Westfalen, Germany
, Mainz, Rheinland-Pfalz, Germany
, Magdeburg, Sachsen-Anhalt, Germany
, Berlin, , Germany
, Hamburg, , Germany
, Budapest, , Hungary
, Debrecen, , Hungary
, Kaposvar, , Hungary
, Napoli, Campania, Italy
, Bologna, Emilia-Romagna, Italy
, Modena, Emilia-Romagna, Italy
, Roma, Lazio, Italy
, Genova, Liguria, Italy
, Bergamo, Lombardia, Italy
, Milano, Lombardia, Italy
, Milano, Lombardia, Italy
, Novara, Piemonte, Italy
, Torino, Piemonte, Italy
, Foggia, Puglia, Italy
, Cagliari, Sardegna, Italy
, Pisa, Toscana, Italy
, Padova, Veneto, Italy
, Chiba-shi, Chiba, Japan
, Kashiwa-shi, Chiba, Japan
, Fukuoka-shi, Fukuoka, Japan
, Iizuka-shi, Fukuoka, Japan
, Yokohama-shi, Kanagawa, Japan
, Kumamoto-shi, Kumamoto, Japan
, Osaka-shi, Osaka, Japan
, Osakasayama-shi, Osaka, Japan
, Utsunomiya-shi, Tochigi, Japan
, Chiyoda-ku, Tokyo, Japan
, Chuo-ku, Tokyo, Japan
, Musashino-shi, Tokyo, Japan
, Busan, Busan Gwang''yeogsi, Korea, Republic of
, Daegu, , Korea, Republic of
, Seoul, , Korea, Republic of
, Seoul, , Korea, Republic of
, Amsterdam, , Netherlands
, Leiden, , Netherlands
, Barnaul, , Russian Federation
, Moscow, , Russian Federation
, Moscow, , Russian Federation
, Singapore, , Singapore
, Oviedo, Asturias, Spain
, Alicante, , Spain
, Barcelona, , Spain
, Barcelona, , Spain
, Córdoba, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Madrid, , Spain
, Zaragoza, , Spain
, Bellinzona, Ticino, Switzerland
, Bern, , Switzerland
, Kaohsiung City, Kaohsiung, Taiwan
, Taipei, , Taiwan
, Taipei, , Taiwan
, Taoyuan, , Taiwan
, Birmingham, West Midlands, United Kingdom
, Leeds, West Yorkshire, United Kingdom
, Bristol, , United Kingdom
, London, , United Kingdom
, London, , United Kingdom
Name: Bayer Study Director
Affiliation: Bayer
Role: STUDY_DIRECTOR