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Spots Global Cancer Trial Database for A Study of GPC3-targeted T Cells by Intratumor Injection for Advanced HCC (GPC3-CART)

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Trial Identification

Brief Title: A Study of GPC3-targeted T Cells by Intratumor Injection for Advanced HCC (GPC3-CART)

Official Title: An Open-label, Uncontrolled, Single-arm Pilot Study to Evaluate Intratumor Injection Mediated GPC3-targeted Chimeric Antigen Receptor T Cells in Advanced Hepatocellular Carcinoma

Study ID: NCT03130712

Interventions

GPC3-CART cells

Study Description

Brief Summary: In this study, CART cells are targeted to GPC3 by intratumor injected that we hope by this means could improve the local CAR-T cell numbers, meanwhile reduce the potential side effects.

Detailed Description: Patients treated with leukapheresis to obtain peripheral blood mononuclear cells, and then PBMC are purified. T cells are activated and then re-engineered to express chimeric antigen receptors (CARs) specific for GPC3. Cells are expanded in culture and returned to the participant by intratumor injection at the dose of(1-10)×106 CAR positive T cells. The cells perfusion process would only last for (1-2) min. GPC-CART cells are injected into each tumor focus only once.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

302 Military Hospital, Beijing, , China

Contact Details

Name: Lu Yinying, Doctor

Affiliation: Beijing 302 Hospital

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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