Spots Global Cancer Trial Database for A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
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Trial Identification
Brief Title: A Study of Nivolumab and Relatlimab in Combination With Bevacizumab in Advanced Liver Cancer
Official Title: A Phase 1/2, Safety Confirmation, Placebo-controlled, Randomized Study of Nivolumab in Combination With Relatlimab and Bevacizumab in Treatment-naive Advanced/Metastatic Hepatocellular Carcinoma
Study ID: NCT05337137
Conditions
Study Description
Brief Summary: The purpose of this study is to evaluate the safety and effectiveness of triplet therapy of nivolumab, relatlimab and bevacizumab versus nivolumab and bevacizumab in participants with untreated advanced/metastatic hepatocellular carcinoma (HCC).
Detailed Description:
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
USC Norris Comprehensive Cancer Center, Los Angeles, California, United States
University of California - Los Angeles, Los Angeles, California, United States
California Pacific Hematology Oncology Associates, San Francisco, California, United States
Georgetown University Medical Center - Lombardi Comprehensive Cancer Center, Washington, District of Columbia, United States
Johns Hopkins Medicine - Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland, United States
Harvard Medical School - Massachusetts General Hospital MGH - Cancer Center, Boston, Massachusetts, United States
Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States
Albert Einstein School of Medicine Montefiore, Bronx, New York, United States
Memorial Sloan Kettering Cancer Center, New York, New York, United States
Medical College of Wisconsin/ Froedtert Hospital, Milwaukee, Wisconsin, United States
Local Institution - 0045, Camperdown, New South Wales, Australia
Local Institution - 0022, Adelaide, South Australia, Australia
Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia
St. Vincents Hospital, Melbourne, Victoria, Australia
Local Institution - 0017, Nedlands, Western Australia, Australia
Local Institution - 0025, Edmonton, Alberta, Canada
Princess Margaret Hospital, Toronto, Ontario, Canada
Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China
Xian International Medical Center Hospital, Xian, Shan3xi, China
Local Institution - 0021, Avignon, Cedex 9, France
Local Institution, Bondy, , France
Local Institution - 0012, Grenoble, , France
Centre Hospitalier Universitaire de Nice Hopital l Archet (Albert Tran), Nice, , France
Local Institution - 0002, Reims, , France
Centre Eugene Marquis, Rennes, , France
Local Institution - 0054, Suresnes, , France
Universitaetsklinikum Duesseldorf, Duesseldorf, North Rhine-Westphalia, Germany
University Hospital Frankfurt, Frankfurt, , Germany
Universitaetsmedizin der Johannes Gutenberg-University Mainz, Mainz, , Germany
Local Institution - 0055, Munich, , Germany
Queen Mary Hospital, Hong Kong, , Hong Kong
Local Institution - 0031, Shatin, , Hong Kong
Local Institution - 0020, Rozzano, Milano, Italy
Local Institution - 0036, Milano, MI, Italy
Oncology Institute Veneto IOV-IRCCS, Padova, , Italy
Local Institution - 0010, Roma, , Italy
Local Institution - 0047, Kashiwa-shi, Chiba, Japan
Ehime Prefectural Central Hospital, Matsuyama, Ehime, Japan
Kanazawa University Hospital, Kanazawa-shi, Ishikawa, Japan
Yokohama City University Medical Center, Yokohama-shi, Kanagawa, Japan
Local Institution - 0041, Osakasayama, Osaka, Japan
Local Institution - 0063, Tokyo, , Japan
Local Institution - 0037, Seongnam-si, Gyeonggido, Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Centrum Onkologii im. Prof. Franciszka Aukaszczyka, Ambulatorium Chemioterapii, Bydgoszcz, Kujawsko-pomorskie, Poland
M Sklodowska Curie Memorial National Cancer Institute, Warszawa, Mazowieckie, Poland
Local Institution - 0023, Gdansk, Pomorskie, Poland
Pan American Center for Oncology Trials, LLC, Rio Piedras, , Puerto Rico
FDI Clinical Research, San Juan, , Puerto Rico
Local Institution - 0019_NA, San Juan, , Puerto Rico
National Cancer Centre, Singapore, , Singapore
Local Institution - 0027, Singapore, , Singapore
Tan Tock Seng Hospital, Singapore, , Singapore
Local Institution - 0044, Singapore, , Singapore
Hospital Clnico Universitario de Santiago de Compostela, Santiago de Compostela, A Coruña, Spain
Local Institution - 0007, Santander, Cantabria, Spain
Clinica Universidad de Navarra, Madrid, Sede Madrid, Spain
Hospital Universitario La Paz, Madrid, , Spain
Clinica Universidad de Navarra, Pamplona, , Spain
Hospital Universitario Miguel Servet, Zaragoza, , Spain
Local Institution - 0043, District Taichung City, Tai Zhong Shi, Taiwan
Taichung Veterans General Hospital, Taichung, , Taiwan
National Taiwan University Hospital NTUH, Taipei, , Taiwan
Local Institution - 0049, Taipei, , Taiwan
Contact Details
Name: Bristol-Myers Squibb
Affiliation: Bristol-Myers Squibb
Role: STUDY_DIRECTOR
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