Spots Global Cancer Trial Database for A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma
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Trial Identification
Brief Title: A Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma
Official Title: A Phase Ib/II, Open-Label, Multicenter, Randomized Platform Study Evaluating The Efficacy and Safety of Neoadjuvant Immunotherapy Combinations in Patients With Surgically Resectable Hepatocellular Carcinoma (MORPHEUS-NEO HCC)
Study ID: NCT05908786
Conditions
Study Description
Brief Summary: This is a Phase Ib/II, open-label, multicenter, randomized platform study to evaluate neoadjuvant immunotherapy combinations in participants with resectable HCC. The study is designed with the flexibility to open new treatment arms as new agents become available, close existing treatment arms that demonstrate minimal clinical activity or unacceptable toxicity, or modify the participant population.
Detailed Description:
Keywords
Eligibility
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Locations
University of Southern California (USC); Norris Comprehensive Cancer Center, Los Angeles, California, United States
University of California Los Angeles (UCLA) - Cancer Care - Santa Monica, Santa Monica, California, United States
Yale School of Medicine - Smilow Cancer Hospital - Yale-New Haven Hospital Location, New Haven, Colorado, United States
Georgetown University Medical Center, Washington, District of Columbia, United States
Barbara Ann Karmanos Cancer Institute - Karmanos Cancer Center - Main Campus, Detroit, Michigan, United States
Montefiore Einstein Cancer Center, Bronx, New York, United States
Columbia University Medical Center; Herbert Irving Pavilion Location, New York, New York, United States
University of Pennsylvania - Abramson Cancer Center, Philadelphia, Pennsylvania, United States
UT Southwestern Medical Center, Dallas, Texas, United States
Fred Hutchinson/University of Washington Cancer Consortium, Seattle, Washington, United States
Centre Georges Francois Leclerc (CGFL), Dijon, , France
Centre Eugene Marquis (CEM), Rennes, , France
Assistance Publique-Hopitaux de Paris, Villejuif, , France
Gustave Roussy, Villejuif, , France
CHA Bundang Medical Center, Gyeonggi-do, , Korea, Republic of
Severance Hospital, Yonsei University Health System, Seoul, , Korea, Republic of
Asan Medical Center, Seoul, , Korea, Republic of
Samsung Medical Center, Seoul, , Korea, Republic of
Auckland District Health Board (ADHB); Auckland City Hospital (ACH), Auckland, , New Zealand
Hospital Universitario Marques de Valdecilla, Santander, Cantabria, Spain
Clínica Universidad de Navarra, Pamplona, Navarra, Spain
Hospital Universitario Fundacion Jimenez Diaz., Madrid, , Spain
National Cheng Kung University Hospital, Tainan, , Taiwan
Chang Gung Medical Foundation, Kaohsiung Chang Gung Memorial Hospital, Tainan, , Taiwan
Taipei Veterans General Hospital, Taipei City, , Taiwan
National Taiwan University Hospital (NTUH) - Cancer Research Center, Zhongzheng Dist., , Taiwan
Belfast Health and Social Care Trust - Belfast City Hospital, Belfast, , United Kingdom
Imperial College London - Imperial Centre for Translational and Experimental Medicine (ICTEM), London, , United Kingdom
Contact Details
Name: Clinical Trials
Affiliation: Hoffmann-La Roche
Role: STUDY_DIRECTOR
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