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Spots Global Cancer Trial Database for Adjuvant Therapy With Apatinib for HCC Patients With PVTT Who Underwent Radical Resection

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We do not endorse or review these studies in any way.

Trial Identification

Brief Title: Adjuvant Therapy With Apatinib for HCC Patients With PVTT Who Underwent Radical Resection

Official Title: A Exploratory Study of Apatinib Adjuvant Therapy for Hepatocellular Carcinoma With Portal Vein Invasion Who Underwent Radical Resection

Study ID: NCT03261791

Interventions

Apatinib

Study Description

Brief Summary: In this phase 2 study, we aim to evaluate the effects and safety of adjuvant apatinib therapy for the patients who underwent R0 resection for hepatocellular carcinoma with portal vein tumor thrombus.

Detailed Description: Portal vein tumor thrombus (PVTT) is one of the characteristics of advanced stage for patients with hepatocellular carcinoma (HCC). There's limited treatment choice for these patients. Even for those who underwent curative resection (R0 resection), the recurrence rate was extremely high. Apatinib is a highly selective VEGFR2 inhibitor and reduces the angiogenesis of tumor efficiently, which had been proven effective in many solid tumors, is a Chinese domestic TKI targeting vascular endothelial growth factor receptor. Phase 2 study of apatinib for patients with advanced HCC had shown signals of clinical efficacy and modest safety. In this study, we aim to evaluate the effects and safety of adjuvant apatinib therapy for the patients who underwent R0 resection for HCC with PVTT.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Zhongshan Hospital, Shanghai, Shanghai, China

Contact Details

Name: Hui-CHuan Sun, MD&PhD

Affiliation: Fudan University

Role: PRINCIPAL_INVESTIGATOR

Name: Jia Fan, MD&PhD

Affiliation: Fudan University

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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