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Brief Title: Computed Tomography (CT) Perfusion Imaging of Lung Cancer
Official Title: CTP (Computed Tomography Perfusion) Imaging of Lung Cancer
Study ID: NCT00905801
Brief Summary: This is an experimental study of the feasibility and efficacy of CT perfusion (CTP) imaging (CT blood flow measurements) in subjects with non-small cell lung cancer.
Detailed Description: Drug/Device Information 1) Contrast 30 cc bolus of a low osmolar, iodinated CT contrast agent, which is FDA approved and used in the clinical CT Imaging procedure. 2) Scanner The 64 row-multidetector row CT unit (LightSpeed VCT, GE Healthcare, Milwaukee, WI) is FDA approved for clinical CT imaging Research Design and Methods 1) Primary Endpoint 1. Diagnostic yield of tumor perfusion measurements using a contrast assisted computed tomography technique. 2) Secondary Endpoints 1. Reproducibility of tumor blood flow estimates derived by CT. 2. Assessment of the association between tumor vascularity responses after two cycles of chemotherapy and subsequent best tumor response according to standard anatomic response evaluation criteria (RECIST). 3. Predictive value of tumor blood flow for patient survival, compared to the predictive power of tumor size determinations.
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
Hillman Cancer Center: University of Pittsburgh Cancer Institute / UPMC Department of Radiology, Pittsburgh, Pennsylvania, United States
University of Pittsburgh Cancer Institute - Hillman Cancer Center, Pittsburgh, Pennsylvania, United States
University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States
Name: Mark A. Socinski, MD
Affiliation: University of Pittsburgh
Role: PRINCIPAL_INVESTIGATOR