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Brief Title: Afatinib (BIBW 2992) in Advanced Non-Small Cell Lung Cancer Patients With EGFR Mutation
Official Title: An Open Label, Multicentre, Single Arm Trial to Assess the Safety of Afatinib for Patients With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) Harboring EGFR Mutation(s)
Study ID: NCT01953913
Brief Summary: Primary objective of the trial is to evaluate the safety of afatinib in patients with locally advanced or metastatic non-small cell lung cancer (NSCLC) harboring EGFR (Epidermal growth factor receptor) mutation(s) and have never been treated with an EGFR-TKI (tyrosine kinase inhibitor). Secondary objective is to assess the time to symptomatic progression (as judged by investigator).
Detailed Description:
Minimum Age: 18 Years
Eligible Ages: ADULT, OLDER_ADULT
Sex: ALL
Healthy Volunteers: No
307 Hospital of PLA, Beijing, , China
Beijing Cancer Hospital, Beijing, , China
Chinese PLA General Hospital, Beijing, , China
Jilin Province Cancer Hospital, Changchun, , China
Guangdong Provincial People's Hospital, Guangzhou, , China
Zhejiang Cancer Hospital, Hangzhou, , China
Lin Yi Tumor Hospital, Linyi, , China
Jiangsu Cancer Hospital, Nanjing, , China
Shanghai Chest Hospital, Shanghai, , China
Fudan University Shanghai Cancer Center, Shanghai, , China
Shanghai Pulmonary Hospital, Shanghai, , China
Tianjin Medical University Cancer Institute and Hospital, Tianjin, , China
Queen Mary Hospital, Hong Kong, , Hong Kong
Prince of Wales Hospital, Shatin, , Hong Kong
Vikram Hospital, Bangalore, , India
HCG Hospital, Bengaluru, , India
P VS Hospital Pvt Ltd, Calicut, , India
V S Hospital, Chennai, , India
Max Super Speciality Hospital, Delhi, Delhi, , India
Global Hospitals, Hyderabad, , India
Basavatarakam Indo - American Cancer Hospital & Research Ins, Hyderabad, , India
SEAROC Cancer Centre, Jaipur, , India
B. P. Poddar Hospital & Medial Research Ltd, Kolkata,West Bengal, , India
Asirvatham Multispeciality Hospital, Madurai, , India
Curie Manavata Cancer Centre, Maharashtra, , India
Shatabdi Superspeciality Hospital, Maharashtra, , India
Prince Aly Khan Hospital, Mumbai, , India
Ruby Hall Clinic, Pune, , India
National Cancer Centre, Singapore, , Singapore
E-Da Hospital, Kaohsiung, , Taiwan
NCKUH, Tainan, , Taiwan
Tri-Service General Hospital, Taipei, , Taiwan
Chang-Gung Memorial Hospital, Linkou, Taoyuan County, , Taiwan
Name: Boehringer Ingelheim
Affiliation: Boehringer Ingelheim
Role: STUDY_CHAIR