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Spots Global Cancer Trial Database for Trial of Paclitaxel/Carboplatin + PF-3512676 vs Paclitaxel/Carboplatin Alone in Patients With Advanced Non-Small Cell Lung Cancer

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Trial Identification

Brief Title: Trial of Paclitaxel/Carboplatin + PF-3512676 vs Paclitaxel/Carboplatin Alone in Patients With Advanced Non-Small Cell Lung Cancer

Official Title: International, Randomized, Open-Label, Phase 3 Trial of Paclitaxel/Carboplatin Plus PF-3512676 Versus Paclitaxel/Carboplatin Alone as First-Line Treatment of Patients With Advanced Non-Small Cell Lung Cancer

Study ID: NCT00254891

Conditions

Carcinoma, Non-Small-Cell Lung

Interventions

PF-3512676 + Paclitaxel + Carboplatin

Paclitaxel + Carboplatin

Study Description

Brief Summary: To assess the efficacy and safety of PF-3512676 administered in combination with paclitaxel/carboplatin chemotherapy as first-line treatment in patients with locally advanced or metastatic Non-Small-Cell Lung Cancer (NSCLC) and to compare it to the efficacy and safety of paclitaxel

Detailed Description: PF-3512676 dosing was stopped 20 June 2007 in response to DSMC recommendation to close the trial, citing lack of efficacy concerns as the primary reason with a safety issue (sepsis) also contributing to the decision. Subjects were allowed to complete standard of care treatment/survival follow-up. Data collection was completed on 17 July 2008.

Keywords

advanced carcinoma, non-small cell lung, Phase III, Paclitaxel, Taxol, Carboplatin, Paraplatin, PF-3512676, immunotherapy, immune modulator

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Pfizer Investigational Site, Little Rock, Alaska, United States

Pfizer Investigational Site, Hot Springs, Arkansas, United States

Pfizer Investigational Site, Chula Vista, California, United States

Pfizer Investigational Site, La Mesa, California, United States

Pfizer Investigational Site, Oceanside, California, United States

Pfizer Investigational Site, Palm Springs, California, United States

Pfizer Investigational Site, San Diego, California, United States

Pfizer Investigational Site, San Francisco, California, United States

Pfizer Investigational Site, Atlanta, Georgia, United States

Pfizer Investigational Site, Decatur, Georgia, United States

Pfizer Investigational Site, Fayetteville, Georgia, United States

Pfizer Investigational Site, Macon, Georgia, United States

Pfizer Investigational Site, Marietta, Georgia, United States

Pfizer Investigational Site, Tucker, Georgia, United States

Pfizer Investigational Site, Rockford, Illinois, United States

Pfizer Investigational Site, Jefferson, Indiana, United States

Pfizer Investigational Site, New Albany, Indiana, United States

Pfizer Investigational Site, Cedar Rapids, Iowa, United States

Pfizer Investigational Site, Dubuque, Iowa, United States

Pfizer Investigational Site, Lexington, Kentucky, United States

Pfizer Investigational Site, Louisville, Kentucky, United States

Pfizer Investigational Site, Shelbyville, Kentucky, United States

Pfizer Investigational Site, Covington, Louisiana, United States

Pfizer Investigational Site, Gretna, Louisiana, United States

Pfizer Investigational Site, Lafayette, Louisiana, United States

Pfizer Investigational Site, Marrero, Louisiana, United States

Pfizer Investigational Site, Metairie, Louisiana, United States

Pfizer Investigational Site, New Orleans, Louisiana, United States

Pfizer Investigational Site, Biddeford, Maine, United States

Pfizer Investigational Site, Brunswick, Maine, United States

Pfizer Investigational Site, Scarborough, Maine, United States

Pfizer Investigational Site, Worcester, Massachusetts, United States

Pfizer Investigational Site, Allegan, Michigan, United States

Pfizer Investigational Site, Ann Arbor, Michigan, United States

Pfizer Investigational Site, Kalamazoo, Michigan, United States

Pfizer Investigational Site, St. Joseph, Michigan, United States

Pfizer Investigational Site, Columbus, Mississippi, United States

Pfizer Investigational Site, Corinth, Mississippi, United States

Pfizer Investigational Site, Tupelo, Mississippi, United States

Pfizer Investigational Site, Omaha, Nebraska, United States

Pfizer Investigational Site, Papillion, Nebraska, United States

Pfizer Investigational Site, Las Vegas, Nevada, United States

Pfizer Investigational Site, Albuquerque, New Mexico, United States

Pfizer Investigational Site, Ruidoso, New Mexico, United States

Pfizer Investigational Site, Buffalo, New York, United States

Pfizer Investigational Site, Great Neck, New York, United States

Pfizer Investigational Site, Asheville, North Carolina, United States

Pfizer Investigational Site, Brevard, North Carolina, United States

Pfizer Investigational Site, Lexington, North Carolina, United States

Pfizer Investigational Site, Winston-Salem, North Carolina, United States

Pfizer Investigational Site, Canton, Ohio, United States

Pfizer Investigational Site, Dover, Ohio, United States

Pfizer Investigational Site, Oklahoma City, Oklahoma, United States

Pfizer Investigational Site, Portland, Oregon, United States

Pfizer Investigational Site, Langhorne, Pennsylvania, United States

Pfizer Investigational Site, Chattanooga, Tennessee, United States

Pfizer Investigational Site, Memphis, Tennessee, United States

Pfizer Investigational Site, Arlington, Texas, United States

Pfizer Investigational Site, Dallas, Texas, United States

Pfizer Investigational Site, Richardson, Texas, United States

Pfizer Investigational Site, Trophy Club, Texas, United States

Pfizer Investigational Site, Bountiful, Utah, United States

Pfizer Investigational Site, Layton, Utah, United States

Pfizer Investigational Site, Murray, Utah, United States

Pfizer Investigational Site, Provo, Utah, United States

Pfizer Investigational Site, Salt Lake City, Utah, United States

Pfizer Investigational Site, WVC, Utah, United States

Pfizer Investigational Site, Burlington, Vermont, United States

Pfizer Investigational Site, Everett, Washington, United States

Pfizer Investigational Site, Kennewick, Washington, United States

Pfizer Investigational Site, Richland, Washington, United States

Pfizer Investigational Site, Madison, Wisconsin, United States

Pfizer Investigational Site, Albury, New South Wales, Australia

Pfizer Investigational Site, Camperdown, New South Wales, Australia

Pfizer Investigational Site, Randwick, New South Wales, Australia

Pfizer Investigational Site, Pimlico, Queensland, Australia

Pfizer Investigational Site, Townsville, Queensland, Australia

Pfizer Investigational Site, Woolloongabba, Queensland, Australia

Pfizer Investigational Site, Bedford Park, South Australia, Australia

Pfizer Investigational Site, Toorak Gardens, South Australia, Australia

Pfizer Investigational Site, East Melbourne, Victoria, Australia

Pfizer Investigational Site, East Ringwood, Victoria, Australia

Pfizer Investigational Site, Wodonga, Victoria, Australia

Pfizer Investigational Site, Nedlands, Western Australia, Australia

Pfizer Investigational Site, Gent, , Belgium

Pfizer Investigational Site, Liège, , Belgium

Pfizer Investigational Site, Moncton, New Brunswick, Canada

Pfizer Investigational Site, Montreal, Quebec, Canada

Pfizer Investigational Site, Rimouski, Quebec, Canada

Pfizer Investigational Site, Saskatoon, Saskatchewan, Canada

Pfizer Investigational Site, Dalian, Xigang District, Liaoning, China

Pfizer Investigational Site, Beijing, , China

Pfizer Investigational Site, Shanghai, , China

Pfizer Investigational Site, Nicosia, , Cyprus

Pfizer Investigational Site, Nova Ves Pod Plesi, , Czech Republic

Pfizer Investigational Site, Ostrava-Poruba, , Czech Republic

Pfizer Investigational Site, Usti nad Labem, , Czech Republic

Pfizer Investigational Site, Angers cedex, , France

Pfizer Investigational Site, Caen cedex, , France

Pfizer Investigational Site, Dijon, , France

Pfizer Investigational Site, Limoges, , France

Pfizer Investigational Site, Nantes Cedex 2, , France

Pfizer Investigational Site, Paris Cedex 13, , France

Pfizer Investigational Site, St Herblain Cedex, , France

Pfizer Investigational Site, Strasbourg, , France

Pfizer Investigational Site, Toulouse cedex 9, , France

Pfizer Investigational Site, Vandoeuvre Les Nancy, , France

Pfizer Investigational Site, Berlin, , Germany

Pfizer Investigational Site, Bielefeld, , Germany

Pfizer Investigational Site, Bonn, , Germany

Pfizer Investigational Site, Essen, , Germany

Pfizer Investigational Site, Frankfurt, , Germany

Pfizer Investigational Site, Karlsruhe, , Germany

Pfizer Investigational Site, Muenchen, , Germany

Pfizer Investigational Site, Athens, Attica, Greece

Pfizer Investigational Site, Heraklion, Crete, Greece

Pfizer Investigational Site, Thessaloniki, Macedonia, Greece

Pfizer Investigational Site, Athens, , Greece

Pfizer Investigational Site, Rio, Patras, , Greece

Pfizer Investigational Site, Pokfulam, , Hong Kong

Pfizer Investigational Site, Budapest, , Hungary

Pfizer Investigational Site, Debrecen, , Hungary

Pfizer Investigational Site, Bangalore, Karnataka, India

Pfizer Investigational Site, Kochi, Kerala, India

Pfizer Investigational Site, Pune, Maharashtra, India

Pfizer Investigational Site, Chandigarh, Punjab, India

Pfizer Investigational Site, Jaipur, Rajasthan, India

Pfizer Investigational Site, Zerifin, , Israel

Pfizer Investigational Site, Lido di Camaiore (LU), , Italy

Pfizer Investigational Site, Milano, , Italy

Pfizer Investigational Site, Napoli, , Italy

Pfizer Investigational Site, Pavia, , Italy

Pfizer Investigational Site, Seoul, , Korea, Republic of

Pfizer Investigational Site, Mexico, DF, Mexico

Pfizer Investigational Site, Puebla, , Mexico

Pfizer Investigational Site, Tiel, GLD, Netherlands

Pfizer Investigational Site, Groningen, GR, Netherlands

Pfizer Investigational Site, Amstelveen, , Netherlands

Pfizer Investigational Site, Den Haag, , Netherlands

Pfizer Investigational Site, Otwock, , Poland

Pfizer Investigational Site, Wodzislaw Sl., , Poland

Pfizer Investigational Site, Faro, , Portugal

Pfizer Investigational Site, Porto, , Portugal

Pfizer Investigational Site, Vila Nova de Gaia, , Portugal

Pfizer Investigational Site, Parktown, Gauteng, South Africa

Pfizer Investigational Site, Cape Town, , South Africa

Pfizer Investigational Site, Johannesburg, , South Africa

Pfizer Investigational Site, Badalona, Barcelona, Spain

Pfizer Investigational Site, Alcorcon, Madrid, Spain

Pfizer Investigational Site, Pamplona, Navarra, Spain

Pfizer Investigational Site, Madrid, , Spain

Pfizer Investigational Site, Santa Cruz de Tenerife, , Spain

Pfizer Investigational Site, Valencia, , Spain

Pfizer Investigational Site, Stockholm, , Sweden

Pfizer Investigational Site, Uppsala, , Sweden

Pfizer Investigational Site, Lausanne, , Switzerland

Pfizer Investigational Site, Taipei, , Taiwan

Pfizer Investigational Site, Truro, Cornwall, United Kingdom

Pfizer Investigational Site, Exeter, Devon, United Kingdom

Pfizer Investigational Site, London, , United Kingdom

Pfizer Investigational Site, Portsmouth, , United Kingdom

Pfizer Investigational Site, Sheffield, , United Kingdom

Pfizer Investigational Site, Surrey GU2 5XX, , United Kingdom

Pfizer Investigational Site, Swansea, , United Kingdom

Contact Details

Name: Pfizer CT.gov Call Center

Affiliation: Pfizer

Role: STUDY_DIRECTOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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