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Spots Global Cancer Trial Database for Computed Tomography (CT) Perfusion Imaging of Lung Cancer

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Trial Identification

Brief Title: Computed Tomography (CT) Perfusion Imaging of Lung Cancer

Official Title: CTP (Computed Tomography Perfusion) Imaging of Lung Cancer

Study ID: NCT00905801

Interventions

CT Perfusion

Study Description

Brief Summary: This is an experimental study of the feasibility and efficacy of CT perfusion (CTP) imaging (CT blood flow measurements) in subjects with non-small cell lung cancer.

Detailed Description: Drug/Device Information 1) Contrast 30 cc bolus of a low osmolar, iodinated CT contrast agent, which is FDA approved and used in the clinical CT Imaging procedure. 2) Scanner The 64 row-multidetector row CT unit (LightSpeed VCT, GE Healthcare, Milwaukee, WI) is FDA approved for clinical CT imaging Research Design and Methods 1) Primary Endpoint 1. Diagnostic yield of tumor perfusion measurements using a contrast assisted computed tomography technique. 2) Secondary Endpoints 1. Reproducibility of tumor blood flow estimates derived by CT. 2. Assessment of the association between tumor vascularity responses after two cycles of chemotherapy and subsequent best tumor response according to standard anatomic response evaluation criteria (RECIST). 3. Predictive value of tumor blood flow for patient survival, compared to the predictive power of tumor size determinations.

Eligibility

Minimum Age: 18 Years

Eligible Ages: ADULT, OLDER_ADULT

Sex: ALL

Healthy Volunteers: No

Locations

Hillman Cancer Center: University of Pittsburgh Cancer Institute / UPMC Department of Radiology, Pittsburgh, Pennsylvania, United States

University of Pittsburgh Cancer Institute - Hillman Cancer Center, Pittsburgh, Pennsylvania, United States

University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania, United States

Contact Details

Name: Mark A. Socinski, MD

Affiliation: University of Pittsburgh

Role: PRINCIPAL_INVESTIGATOR

Useful links and downloads for this trial

Clinicaltrials.gov

Google Search Results

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